ArticleFrontiers in neuroscience2016
Language Impairments in ASD Resulting from a Failed Domestication of the Human Brain.
Article in Frontiers in neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 75 citations in OpenAlex.
- Natural selection and language genes in humans.Scientific reports · 2026Article
- A common genetic variant in the Neurexin family member CNTNAP2 is related to language but not communication skills in youth with Autism Spectrum Disorder.Autism research : official journal of the International Society for Autism Research · 2025Article
- A Biopsychosocial Overview of Speech Disorders: Neuroanatomical, Genetic, and Environmental Insights.Biomedicines · 2025Review
- High neural noise in autism: A hypothesis currently at the nexus of explanatory power.Heliyon · 2024Review
- How (and why) languages became more complex as we evolved more prosocial: the human self-domestication view.Frontiers in psychology · 2024Article
- Enrichment of self-domestication and neural crest function loci in the heritability of neurodevelopmental disorders.Human genetics · 2023Article
- 'The best way to get it right is to listen to us' - autistic people argue for a stronger voice in research.Nature · 2023Article
- An evolutionary account of impairment of self in cognitive disorders.Cognitive processing · 2023Article
- Toward an evolutionary account of the changes in the human pitch vocal system.Frontiers in psychology · 2023Article
- 'We've come a very, very, long way' Overcoming stigma of autism: An interpretative phenomenological analysis within the UK Jewish community.Autism : the international journal of research and practice · 2022Article
- Article
- Identification of methylation markers for diagnosis of autism spectrum disorder.Metabolic brain disease · 2022Article
- Autism and Williams syndrome: truly mirror conditions in the socio-cognitive domain?International journal of developmental disabilities · 2022Review
- Integration of structural MRI and epigenetic analyses hint at linked cellular defects of the subventricular zone and insular cortex in autism: Findings from a case study.Frontiers in neuroscience · 2022Article
- Potential crosstalk between sonic hedgehog-WNT signaling and neurovascular molecules: Implications for blood-brain barrier integrity in autism spectrum disorder.Journal of neurochemistry · 2021Review
- Language evolution: examining the link between cross-modality and aggression through the lens of disorders.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- Mental time travel, language evolution, and human self-domestication.Cognitive processing · 2021Article
- Autism Spectrum Disorder: Signaling Pathways and Prospective Therapeutic Targets.Cellular and molecular neurobiology · 2021Review
- Did Dog Domestication Contribute to Language Evolution?Frontiers in psychology · 2021Article
- Academic, Activist, or Advocate? Angry, Entangled, and Emerging: A Critical Reflection on Autism Knowledge Production.Frontiers in psychology · 2021Review
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autism spectrum disorders (ASD) are pervasive neurodevelopmental disorders entailing social and cognitive deficits, including marked problems with language. Numerous genes have been associated with ASD, but it is unclear how language deficits arise from gene mutation or dysregulation. It is also unclear why ASD shows such high prevalence within human populations. Interestingly, the emergence of a modern faculty of language has been hypothesized to be linked to changes in the human brain/skull, but also to the process of self-domestication of the human species. It is our intention to show that people with ASD exhibit less marked domesticated traits at the morphological, physiological, and behavioral levels. We also discuss many ASD candidates represented among the genes known to be involved in the "domestication syndrome" (the constellation of traits exhibited by domesticated mammals, which seemingly results from the hypofunction of the neural crest) and among the set of genes involved in language function closely connected to them. Moreover, many of these genes show altered expression profiles in the brain of autists. In addition, some candidates for domestication and language-readiness show the same expression profile in people with ASD and chimps in different brain areas involved in language processing. Similarities regarding the brain oscillatory behavior of these areas can be expected too. We conclude that ASD may represent an abnormal ontogenetic itinerary for the human faculty of language resulting in part from changes in genes important for the "domestication syndrome" and, ultimately, from the normal functioning of the neural crest.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.