Evidence map›Paper›PMID 27621607›Full record

ReviewClinical interventions in aging2016

Managing infective endocarditis in the elderly: new issues for an old disease.

Emmanuel Forestier, Thibaut Fraisse, Claire Roubaud-Baudron, Christine Selton-Suty, Leonardo Pagani

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Clinical interventions in aging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02910856 (Infective Endocarditis in the Elderly), which is not on this map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02910856 completednot on this map

Infective Endocarditis in the Elderly: Description of the Geriatric Characteristics and Their Influence on Therapeutic Care and the Morbidity and Mortality at 3 Months (ELDERL-IE)

TypeobservationalSponsorCentral Hospital, Nancy, FranceRan2015 to 2017Enrolled120ConditionsInfective Endocarditis
3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Patterns of Infectious Disease Associated With Injection Drug Use in Massachusetts.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Infective Endocarditis in the Elderly: Challenges and Strategies.Journal of cardiovascular development and disease · 2022
    Review
  14. Review
  15. Article
  16. Article
  17. Infective Endocarditis in the Elderly: Distinct Characteristics.Arquivos brasileiros de cardiologia · 2021
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Emmanuel ForestierInfectious Diseases Department, Centre Hospitalier Métropole Savoie, Chambéry, France.
Thibaut FraisseAcute Geriatric Department, Centre Hospitalier, Alès, France.
Claire Roubaud-BaudronGeriatric Department, University Hospital, Bordeaux, France.
Christine Selton-SutyDepartment of Cardiology, University Hospital, Nancy, France.
Leonardo PaganiInfectious Diseases Department, Centre Hospitalier Annecy-Genevois, Annecy, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The incidence of infective endocarditis (IE) rises in industrialized countries. Older people are more affected by this severe disease, notably because of the increasing number of invasive procedures and intracardiac devices implanted in these patients. Peculiar clinical and echocardiographic features, microorganisms involved, and prognosis of IE in elderly have been underlined in several studies. Additionally, elderly population appears quite heterogeneous, from healthy people without past medical history to patients with multiple diseases or who are even bedridden. However, the management of IE in this population has been poorly explored, and international guidelines do not recommend adapting the therapeutic strategy to the patient's functional status and comorbidities. Yet, if IE should be treated according to current recommendations in the healthiest patients, concerns may rise for older patients who suffer from several chronic diseases, especially renal failure, and are on polypharmacy. Treating frailest patients with high-dose intravenous antibiotics during a prolonged hospital stay as recommended for younger patients could also expose them to functional decline and toxic effect. Likewise, the place of surgery according to the aging characteristics of each patient is unclear. The aim of this article is to review the recent data on epidemiology of IE and its peculiarities in the elderly. Then, its management and various therapeutic approaches that can be considered according to and beyond guidelines depending on patient comorbidities and frailty are discussed.

Indexed as

Frail ElderlyAgedAged, 80 and overAnti-Bacterial AgentsCardiac Surgical ProceduresComorbidityDisease ManagementEndocarditisHumansIncidencePractice Guidelines as TopicRisk FactorsAnti-Bacterial Agentsantibiotic therapycardiac surgeryelderlyfrailtyinfective endocarditis

Identifiers

PMID27621607
PMCPMC5015881

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.