ArticleClinical ophthalmology (Auckland, N.Z.)2016
Macular pigment optical density: repeatability, intereye correlation, and effect of ocular dominance.
Article in Clinical ophthalmology (Auckland, N.Z.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Pooled it
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- Effects of Long-Term Supplementation withNutrients · 2026Trial
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- Evaluation of a Portable Handheld Heterochromatic Flicker Photometer in Measuring Macular Pigment Optical Density.Diagnostics (Basel, Switzerland) · 2025Article
- An integrative examination of psychological distress and its nutritional and visual correlates among young adults in Ghana.PloS one · 2025Article
- Review
- Analysis of Macular Pigment Optical Density in Macular Holes with Different Border Phenotypes.Ophthalmology and therapy · 2024Article
- Effect of supplementation with lutein, zeaxanthin, and omega-3 fatty acids on macular pigment and visual function in young adults with long-term use of digital devices: study protocol for a randomized double-blind placebo-controlled study.Frontiers in nutrition · 2024Article
- The relationship between inflammatory biomarkers and macular pigment optical density in hypertensive patients: a cross-sectional study.Asian biomedicine : research, reviews and news · 2023Article
- Article
- A Systematic Review of Carotenoids in the Management of Age-Related Macular Degeneration.Antioxidants (Basel, Switzerland) · 2021Review
- Article
- Evaluation of Macular Pigment Optical Density in Healthy Eyes Based on Dual-Wavelength Autofluorescence Imaging in South Indian Population.Translational vision science & technology · 2020Article
- Objective method for measuring the macular pigment optical density in the eye.Biomedical optics express · 2019Article
- Macular pigment optical density in a Brazilian sample.International journal of retina and vitreous · 2018Article
- Differences in macular pigment optical density across four ethnicities: a comparative study.Therapeutic advances in ophthalmologyArticle
- Correlations between internal and external ocular factors and macular pigment optical density.Romanian journal of ophthalmologyObservational
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate short-term repeatability, intereye correlation, and effect of ocular dominance on macular pigment optical density (MPOD) measurements obtained using the QuantifEye Heterochromatic Flicker Photometer. PATIENTS AND
methodsA total of 72 study participants were enrolled in this prospective, cross-sectional study. Participants underwent a comprehensive ocular evaluation, including visual acuity, evaluation of ocular dominance, slit lamp examination, intraocular pressure measurement, and optic nerve head and macula analysis using optical coherence tomography and fundus photography. All study participants after initial training underwent MPOD measurement twice in both eyes in a randomized sequence. The repeatability was tested using Altman and Bland plots for first measurements with the second measurements for right eye and left eye and additionally by grouping eyes as a function of ocular dominance. The Pearson correlation coefficient was performed to assess the intereye correlation of MPOD values.
resultsThe mean age of study participants was 35.5 years (range 22-68 years). The mean MPOD measurements for OD (right eye) and OS (left eye) were 0.47 and 0.48, respectively, which followed a normal distribution (Shapiro-Wilk test, P=0.6 and 0.2). The 95% limits of agreement of Altman and Bland plots for the first and second measurements were -0.12 to +0.11 and -0.13 to +0.12 for OD and OS, respectively. The correlation coefficient of mean MPOD measurements of OD and OS was r statistic =0.94 (Pearson correlation coefficient P<0.0001; r (2) 0.89). The 95% limits of agreement of Altman and Bland plots when evaluated by laterality of eye or by ocular dominance were narrow, with limits of agreement ranging from -0.13 to +0.12.
conclusionThe MPOD measurements obtained using the QuantifEye show good short-term repeatability. There is excellent intereye correlation, indicating that the MPOD values of one eye data can predict the fellow eye value with 89% accuracy. The ocular dominance had no bearing on the outcome of this psychophysical test in ocular healthy eyes.
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