ArticleProceedings of the National Academy of Sciences of the United States of America2016
Differential structured illumination microendoscopy for in vivo imaging of molecular contrast agents.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- In Vivo Microendoscopy in the Near-Infrared II Window.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Activation of mechanoluminescent nanotransducers by focused ultrasound enables light delivery to deep-seated tissue in vivo.Nature protocols · 2023Article
- Advances in optical gastrointestinal endoscopy: a technical review.Molecular oncology · 2021Review
- Deep learning extended depth-of-field microscope for fast and slide-free histology.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Automatic motion compensation for structured illumination endomicroscopy using a flexible fiber bundle.Journal of biomedical optics · 2020Article
- In vivo imaging of cervical precancer using a low-cost and easy-to-use confocal microendoscope.Biomedical optics express · 2020Article
- Simple differential digital confocal aperture to improve axial response of line-scanning confocal microendoscopes.Optics letters · 2019Article
- Advances in technologies for cervical cancer detection in low-resource settings.Expert review of molecular diagnostics · 2019Review
- Fast confocal fluorescence imaging in freely behaving mice.Scientific reports · 2018Article
- Perspectives on Strengthening Cancer Research and Control in Latin America Through Partnerships and Diplomacy: Experience of the National Cancer Institute's Center for Global Health.Journal of global oncology · 2018Review
- Non-labeled lensless micro-endoscopic approach for cellular imaging through highly scattering media.Bioscience reports · 2018Article
- Line-scanning confocal microendoscope for nuclear morphometry imaging.Journal of biomedical optics · 2017Article
- Line-scanning hyperspectral imaging based on structured illumination optical sectioning.Biomedical optics express · 2017Article
- Profile of Rebecca Richards-Kortum.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Fiber optic microendoscopy has shown promise for visualization of molecular contrast agents used to study disease in vivo. However, fiber optic microendoscopes have limited optical sectioning capability, and image contrast is limited by out-of-focus light generated in highly scattering tissue. Optical sectioning techniques have been used in microendoscopes to remove out-of-focus light but reduce imaging speed or rely on bulky optical elements that prevent in vivo imaging. Here, we present differential structured illumination microendoscopy (DSIMe), a fiber optic system that can perform structured illumination in real time for optical sectioning without any opto-mechanical components attached to the distal tip of the fiber bundle. We demonstrate the use of DSIMe during in vivo fluorescence imaging in patients undergoing surgery for cervical adenocarcinoma in situ. Images acquired using DSIMe show greater contrast than standard microendoscopy, improving the ability to detect cellular atypia associated with neoplasia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.