ArticleProceedings of the National Academy of Sciences of the United States of America2016
Tuning electronic transport via hepta-alanine peptides junction by tryptophan doping.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 99 citations in OpenAlex.
- Solvent Environment Influences Molecular Conformation and Electron Transport in Peptides.The journal of physical chemistry letters · 2026Article
- Phosphorylation-Dependent Charge Transport in Biomolecular Junctions of Major Histocompatibility Complex Phosphopeptides.The journal of physical chemistry. B · 2026Article
- Single-Molecule Conductance of Non-Redox Proteins: Mechanisms, Measurements, and Applications.Biomolecules · 2026Review
- Single-Molecule Electron Transport in Peptoids.The journal of physical chemistry. B · 2026Article
- Aromatic Amide Foldamers Show Conformation-Dependent Electronic Properties.Chemphyschem : a European journal of chemical physics and physical chemistry · 2025Article
- Amino Acid Sequence Controls Enhanced Electron Transport in Heme-Binding Peptide Monolayers.ACS central science · 2025Article
- Nickel-Dithiolene Cofactors as Electron Donors and Acceptors in Protein Hosts.The journal of physical chemistry. B · 2025Article
- Secondary structure determines electron transport in peptides.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- CP-AFM Molecular Tunnel Junctions with Alkyl Backbones Anchored Using Alkynyl and Thiol Groups: Microscopically Different Despite Phenomenological Similarity.Langmuir : the ACS journal of surfaces and colloids · 2024Article
- Odd-Even Effect in Peptide SAMs-Competition of Secondary Structure and Molecule-Substrate Interaction.The journal of physical chemistry. B · 2021Article
- Multifaceted aspects of charge transfer.Physical chemistry chemical physics : PCCP · 2020Article
- Photo-induced carbocation-enhanced charge transport in single-molecule junctions.Chemical science · 2020Article
- High Density Display of an Anti-Angiogenic Peptide on Micelle Surfaces Enhances Their Inhibition of αvβ3 Integrin-Mediated Neovascularization In Vitro.Nanomaterials (Basel, Switzerland) · 2020Article
- Role of contacts in long-range protein conductance.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Effect of Crotalus basiliscus snake venom on the redox reaction of myoglobin.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2019Article
- Tailor-Made Functional Peptide Self-Assembling Nanostructures.Advanced materials (Deerfield Beach, Fla.) · 2018Review
- Why one can expect large rectification in molecular junctions based on alkane monothiols and why rectification is so modest.Chemical science · 2018Article
- Article
- Probing Charge Transport through Peptide Bonds.The journal of physical chemistry letters · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Charge migration for electron transfer via the polypeptide matrix of proteins is a key process in biological energy conversion and signaling systems. It is sensitive to the sequence of amino acids composing the protein and, therefore, offers a tool for chemical control of charge transport across biomaterial-based devices. We designed a series of linear oligoalanine peptides with a single tryptophan substitution that acts as a "dopant," introducing an energy level closer to the electrodes' Fermi level than that of the alanine homopeptide. We investigated the solid-state electron transport (ETp) across a self-assembled monolayer of these peptides between gold contacts. The single tryptophan "doping" markedly increased the conductance of the peptide chain, especially when its location in the sequence is close to the electrodes. Combining inelastic tunneling spectroscopy, UV photoelectron spectroscopy, electronic structure calculations by advanced density-functional theory, and dc current-voltage analysis, the role of tryptophan in ETp is rationalized by charge tunneling across a heterogeneous energy barrier, via electronic states of alanine and tryptophan, and by relatively efficient direct coupling of tryptophan to a Au electrode. These results reveal a controlled way of modulating the electrical properties of molecular junctions by tailor-made "building block" peptides.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.