ArticlePlant physiology2016
NAD Acts as an Integral Regulator of Multiple Defense Layers.
Article in Plant physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 87 citations in OpenAlex.
- Domain compositions of Arabidopsis Toll/Interleukin-1 Receptor/Resistance domain-containing TX14 proteins affect localization and induction of the hypersensitive response.Journal of experimental botany · 2026Article
- The NAD salvage pathway enzyme NMNAT-C sustains dark-phase NAD+ homeostasis in cyanobacteria.Plant physiology · 2026Article
- Bamboo mosaic virus-induced metabolic reprogramming engages mitochondrial function to regulate redox homeostasis and defense responses in Nicotiana benthamiana.BMC plant biology · 2025Article
- Cross-kingdom mechanisms of trained immunity in plant systemic acquired resistance.Nature plants · 2025Review
- A rice DELLA protein OsSLR1 positively regulates rice resistance to southern rice black-streaked dwarf virus infection.BMC plant biology · 2025Article
- NADNature communications · 2024Article
- Capsicum chinense Jacq.-derived glutaredoxin (CcGRXS12) alters redox status of the cells to confer resistance against pepper mild mottle virus (PMMoV-I).Plant cell reports · 2024Article
- N-hydroxypipecolic acid triggers systemic acquired resistance through extracellular NAD(P).Nature communications · 2023Article
- The northern corn leaf blight resistance gene Ht1 encodes an nucleotide-binding, leucine-rich repeat immune receptor.Molecular plant pathology · 2023Article
- Pangenomic analysis reveals plant NADProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Ligand recognition and signal transduction by lectin receptor-like kinases in plant immunity.Frontiers in plant science · 2023Review
- ANGUSTIFOLIA negatively regulates resistance to Sclerotinia sclerotiorum via modulation of PTI and JA signalling pathways in Arabidopsis thaliana.Molecular plant pathology · 2022Article
- Molecular and Physiological Effects of Magnesium-Polyphenolic Compound as Biostimulant in Drought Stress Mitigation in Tomato.Plants (Basel, Switzerland) · 2022Article
- A phytobacterial TIR domain effector manipulates NADThe New phytologist · 2022Article
- Unravelling Plant Responses to Stress-The Importance of Targeted and Untargeted Metabolomics.Metabolites · 2021Review
- Knockdown ofInternational journal of molecular sciences · 2021Article
- Roots drive oligogalacturonide-induced systemic immunity in tomato.Plant, cell & environment · 2021Article
- Potential of nicotinamide adenine dinucleotide (NAD) for management of root-knot nematode in tomato.Journal of nematology · 2021Article
- Integration of MsrB1 and MsrB2 in the Redox Network during the Development of Orthodox and RecalcitrantAntioxidants (Basel, Switzerland) · 2020Article
- The essential schistosome tegumental ectoenzyme SmNPP5 can block NAD-induced T cell apoptosis.Virulence · 2020Article
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Authors and funding
5 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pyridine nucleotides, such as NAD, are crucial redox carriers and have emerged as important signaling molecules in stress responses. Previously, we have demonstrated in Arabidopsis (Arabidopsis thaliana) that the inducible NAD-overproducing nadC lines are more resistant to an avirulent strain of Pseudomonas syringae pv tomato (Pst-AvrRpm1), which was associated with salicylic acid-dependent defense. Here, we have further characterized the NAD-dependent immune response in Arabidopsis. Quinolinate-induced stimulation of intracellular NAD in transgenic nadC plants enhanced resistance against a diverse range of (a)virulent pathogens, including Pst-AvrRpt2, Dickeya dadantii, and Botrytis cinerea Characterization of the redox status demonstrated that elevated NAD levels induce reactive oxygen species (ROS) production and the expression of redox marker genes of the cytosol and mitochondrion. Using pharmacological and reverse genetics approaches, we show that NAD-induced ROS production functions independently of NADPH oxidase activity and light metabolism but depends on mitochondrial respiration, which was increased at higher NAD. We further demonstrate that NAD primes pathogen-induced callose deposition and cell death. Mass spectrometry analysis reveals that NAD simultaneously induces different defense hormones and that the NAD-induced metabolic profiles are similar to those of defense-expressing plants after treatment with pathogen-associated molecular patterns. We thus conclude that NAD triggers metabolic profiles rather similar to that of pathogen-associated molecular patterns and discuss how signaling cross talk between defense hormones, ROS, and NAD explains the observed resistance to pathogens.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.