ArticleThe Journal of cell biology2016
Early epithelial signaling center governs tooth budding morphogenesis.
Article in The Journal of cell biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Tooth regeneration in animals. A systematic review.Medicina oral, patologia oral y cirugia bucal · 2025Pooled it
- Article
- Comparative morphogenesis of mouse and rat mandibular first molars (M1): a review of developmental timing, structure, and signaling pathways.Anatomy & cell biology · 2026Review
- Stem cell specification and niche formation in developing incisor require actomyosin forces.Stem cells (Dayton, Ohio) · 2026Article
- Resolving tooth development at single-cell resolution: advancing dental regeneration.Frontiers in cell and developmental biology · 2026Review
- The emergence of the ectodysplasin pathway.Open life sciences · 2026Article
- Impaction Predictors and Diagnostic Performance of CBCT Versus Panoramic Radiography for Supernumerary Teeth in a Romanian Multicenter Cohort.Diagnostics (Basel, Switzerland) · 2025Article
- Notum regulates the cusp and root patterns in mouse molar.Scientific reports · 2024Article
- Proliferation-driven mechanical compression induces signalling centre formation during mammalian organ development.Nature cell biology · 2024Article
- Mobility gene expression differences among wild-type, Mmp20 null and Mmp20 over-expresser mice plus visualization of 3D mouse ameloblast directional movement.Scientific reports · 2023Article
- Using Ex Vivo Live Imaging to Investigate Cell Divisions and Movements During Mouse Dental Renewal.Journal of visualized experiments : JoVE · 2023Article
- Single-cell census of human tooth development enables generation of human enamel.Developmental cell · 2023Article
- Count Me in, Count Me out: Regulation of the Tooth Number via Three Directional Developmental Patterns.International journal of molecular sciences · 2023Review
- Tooth number abnormality: from bench to bedside.International journal of oral science · 2023Review
- Understanding the development of oral epithelial organs through single cell transcriptomic analysis.Development (Cambridge, England) · 2022Article
- What sharks and mammals share.eLife · 2022Article
- An epithelial signalling centre in sharks supports homology of tooth morphogenesis in vertebrates.eLife · 2022Article
- Parallels in signaling between development and regeneration in ectodermal organs.Current topics in developmental biology · 2022Article
- Eda controls the size of the enamel knot during incisor development.Frontiers in physiology · 2022Article
- Cellular mechanisms of reverse epithelial curvature in tissue morphogenesis.Frontiers in cell and developmental biology · 2022Review
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
During organogenesis, cell fate specification and patterning are regulated by signaling centers, specialized clusters of morphogen-expressing cells. In many organs, initiation of development is marked by bud formation, but the cellular mechanisms involved are ill defined. Here, we use the mouse incisor tooth as a model to study budding morphogenesis. We show that a group of nonproliferative epithelial cells emerges in the early tooth primordium and identify these cells as a signaling center. Confocal live imaging of tissue explants revealed that although these cells reorganize dynamically, they do not reenter the cell cycle or contribute to the growing tooth bud. Instead, budding is driven by proliferation of the neighboring cells. We demonstrate that the activity of the ectodysplasin/Edar/nuclear factor κB pathway is restricted to the signaling center, and its inactivation leads to fewer quiescent cells and a smaller bud. These data functionally link the signaling center size to organ size and imply that the early signaling center is a prerequisite for budding morphogenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.