Evidence map›Paper›PMID 27621357›Full record

SynthesisCirculation. Cardiovascular imaging2016

Presence of Late Gadolinium Enhancement by Cardiac Magnetic Resonance Among Patients With Suspected Cardiac Sarcoidosis Is Associated With Adverse Cardiovascular Prognosis: A Systematic Review and Meta-Analysis.

Edward Hulten, Vikram Agarwal, Michael Cahill, Geoff Cole, Tomas Vita, Scott Parrish, Marcio Sommer Bittencourt, Venkatesh L Murthy, Raymond Kwong, Marcelo F Di Carli and 1 more

Open access · bronzeAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Circulation. Cardiovascular imaging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
101citing papers in PubMed, 5 pooled it
11.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

101 citing papers in PubMed, 5 syntheses or guidelines pooled it, 207 citations in OpenAlex.

  1. Pooled it
  2. Brazilian Society of Cardiology Guideline on Myocarditis - 2022.Arquivos brasileiros de cardiologia · 2022
    Guideline
  3. Pooled it
  4. Guideline
  5. Performance of Cardiac Magnetic Resonance Imaging for Diagnosis of Myocarditis Compared with Endomyocardial Biopsy: A Meta-Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2017
    Pooled it
  6. Observational
  7. Imaging phenotypes and substrates in ventricular tachycardia.Herzschrittmachertherapie & Elektrophysiologie · 2026
    Review
  8. Review
  9. Beyond the Biopsy: Imaging Frontiers in Cardiac Sarcoidosis.Cardiology research and practice · 2026
    Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Cardiac Magnetic Resonance in Heart Failure: Diagnostic and Prognostic Assessments.Journal of cardiovascular development and disease · 2025
    Review
  19. Review
  20. Article

41 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Edward HultenFrom the Non-Invasive Cardiovascular Imaging Program, Departments of Medicine and Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (E.H., V.A., T.V., R.K., M.F.D.C., R.B.); Cardiology Service (E.H., M.C., G.C.) and Pulmonology Service (S.P.), Division of Medicine, Walter Reed National Military Medical Center and Uniformed Services University of Health Sciences, Bethesda, MD; Center for Clinical and Epidemiological Research, University Hospital and São Paulo State Cancer Institute-University of São Paulo, Brazil (M.S.B.); Preventive Medicine Center-Hospital Israelita Albert Einstein, São Paulo, Brazil (M.S.B); Frankel Cardiovascular Center, Department of Internal Medicine, Division of Cardiovascular Medicine and Department of Radiology, Division of Nuclear Medicine and Cardiothoracic Imaging, University of Michigan, Ann Arbor (V.L.M.).
Vikram AgarwalFrom the Non-Invasive Cardiovascular Imaging Program, Departments of Medicine and Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (E.H., V.A., T.V., R.K., M.F.D.C., R.B.); Cardiology Service (E.H., M.C., G.C.) and Pulmonology Service (S.P.), Division of Medicine, Walter Reed National Military Medical Center and Uniformed Services University of Health Sciences, Bethesda, MD; Center for Clinical and Epidemiological Research, University Hospital and São Paulo State Cancer Institute-University of São Paulo, Brazil (M.S.B.); Preventive Medicine Center-Hospital Israelita Albert Einstein, São Paulo, Brazil (M.S.B); Frankel Cardiovascular Center, Department of Internal Medicine, Division of Cardiovascular Medicine and Department of Radiology, Division of Nuclear Medicine and Cardiothoracic Imaging, University of Michigan, Ann Arbor (V.L.M.).
Michael CahillFrom the Non-Invasive Cardiovascular Imaging Program, Departments of Medicine and Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (E.H., V.A., T.V., R.K., M.F.D.C., R.B.); Cardiology Service (E.H., M.C., G.C.) and Pulmonology Service (S.P.), Division of Medicine, Walter Reed National Military Medical Center and Uniformed Services University of Health Sciences, Bethesda, MD; Center for Clinical and Epidemiological Research, University Hospital and São Paulo State Cancer Institute-University of São Paulo, Brazil (M.S.B.); Preventive Medicine Center-Hospital Israelita Albert Einstein, São Paulo, Brazil (M.S.B); Frankel Cardiovascular Center, Department of Internal Medicine, Division of Cardiovascular Medicine and Department of Radiology, Division of Nuclear Medicine and Cardiothoracic Imaging, University of Michigan, Ann Arbor (V.L.M.).
Geoff ColeFrom the Non-Invasive Cardiovascular Imaging Program, Departments of Medicine and Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (E.H., V.A., T.V., R.K., M.F.D.C., R.B.); Cardiology Service (E.H., M.C., G.C.) and Pulmonology Service (S.P.), Division of Medicine, Walter Reed National Military Medical Center and Uniformed Services University of Health Sciences, Bethesda, MD; Center for Clinical and Epidemiological Research, University Hospital and São Paulo State Cancer Institute-University of São Paulo, Brazil (M.S.B.); Preventive Medicine Center-Hospital Israelita Albert Einstein, São Paulo, Brazil (M.S.B); Frankel Cardiovascular Center, Department of Internal Medicine, Division of Cardiovascular Medicine and Department of Radiology, Division of Nuclear Medicine and Cardiothoracic Imaging, University of Michigan, Ann Arbor (V.L.M.).
Tomas VitaFrom the Non-Invasive Cardiovascular Imaging Program, Departments of Medicine and Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (E.H., V.A., T.V., R.K., M.F.D.C., R.B.); Cardiology Service (E.H., M.C., G.C.) and Pulmonology Service (S.P.), Division of Medicine, Walter Reed National Military Medical Center and Uniformed Services University of Health Sciences, Bethesda, MD; Center for Clinical and Epidemiological Research, University Hospital and São Paulo State Cancer Institute-University of São Paulo, Brazil (M.S.B.); Preventive Medicine Center-Hospital Israelita Albert Einstein, São Paulo, Brazil (M.S.B); Frankel Cardiovascular Center, Department of Internal Medicine, Division of Cardiovascular Medicine and Department of Radiology, Division of Nuclear Medicine and Cardiothoracic Imaging, University of Michigan, Ann Arbor (V.L.M.).
Scott ParrishFrom the Non-Invasive Cardiovascular Imaging Program, Departments of Medicine and Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (E.H., V.A., T.V., R.K., M.F.D.C., R.B.); Cardiology Service (E.H., M.C., G.C.) and Pulmonology Service (S.P.), Division of Medicine, Walter Reed National Military Medical Center and Uniformed Services University of Health Sciences, Bethesda, MD; Center for Clinical and Epidemiological Research, University Hospital and São Paulo State Cancer Institute-University of São Paulo, Brazil (M.S.B.); Preventive Medicine Center-Hospital Israelita Albert Einstein, São Paulo, Brazil (M.S.B); Frankel Cardiovascular Center, Department of Internal Medicine, Division of Cardiovascular Medicine and Department of Radiology, Division of Nuclear Medicine and Cardiothoracic Imaging, University of Michigan, Ann Arbor (V.L.M.).
Marcio Sommer BittencourtFrom the Non-Invasive Cardiovascular Imaging Program, Departments of Medicine and Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (E.H., V.A., T.V., R.K., M.F.D.C., R.B.); Cardiology Service (E.H., M.C., G.C.) and Pulmonology Service (S.P.), Division of Medicine, Walter Reed National Military Medical Center and Uniformed Services University of Health Sciences, Bethesda, MD; Center for Clinical and Epidemiological Research, University Hospital and São Paulo State Cancer Institute-University of São Paulo, Brazil (M.S.B.); Preventive Medicine Center-Hospital Israelita Albert Einstein, São Paulo, Brazil (M.S.B); Frankel Cardiovascular Center, Department of Internal Medicine, Division of Cardiovascular Medicine and Department of Radiology, Division of Nuclear Medicine and Cardiothoracic Imaging, University of Michigan, Ann Arbor (V.L.M.).
Venkatesh L MurthyFrom the Non-Invasive Cardiovascular Imaging Program, Departments of Medicine and Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (E.H., V.A., T.V., R.K., M.F.D.C., R.B.); Cardiology Service (E.H., M.C., G.C.) and Pulmonology Service (S.P.), Division of Medicine, Walter Reed National Military Medical Center and Uniformed Services University of Health Sciences, Bethesda, MD; Center for Clinical and Epidemiological Research, University Hospital and São Paulo State Cancer Institute-University of São Paulo, Brazil (M.S.B.); Preventive Medicine Center-Hospital Israelita Albert Einstein, São Paulo, Brazil (M.S.B); Frankel Cardiovascular Center, Department of Internal Medicine, Division of Cardiovascular Medicine and Department of Radiology, Division of Nuclear Medicine and Cardiothoracic Imaging, University of Michigan, Ann Arbor (V.L.M.).
Raymond KwongFrom the Non-Invasive Cardiovascular Imaging Program, Departments of Medicine and Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (E.H., V.A., T.V., R.K., M.F.D.C., R.B.); Cardiology Service (E.H., M.C., G.C.) and Pulmonology Service (S.P.), Division of Medicine, Walter Reed National Military Medical Center and Uniformed Services University of Health Sciences, Bethesda, MD; Center for Clinical and Epidemiological Research, University Hospital and São Paulo State Cancer Institute-University of São Paulo, Brazil (M.S.B.); Preventive Medicine Center-Hospital Israelita Albert Einstein, São Paulo, Brazil (M.S.B); Frankel Cardiovascular Center, Department of Internal Medicine, Division of Cardiovascular Medicine and Department of Radiology, Division of Nuclear Medicine and Cardiothoracic Imaging, University of Michigan, Ann Arbor (V.L.M.).
Marcelo F Di CarliFrom the Non-Invasive Cardiovascular Imaging Program, Departments of Medicine and Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (E.H., V.A., T.V., R.K., M.F.D.C., R.B.); Cardiology Service (E.H., M.C., G.C.) and Pulmonology Service (S.P.), Division of Medicine, Walter Reed National Military Medical Center and Uniformed Services University of Health Sciences, Bethesda, MD; Center for Clinical and Epidemiological Research, University Hospital and São Paulo State Cancer Institute-University of São Paulo, Brazil (M.S.B.); Preventive Medicine Center-Hospital Israelita Albert Einstein, São Paulo, Brazil (M.S.B); Frankel Cardiovascular Center, Department of Internal Medicine, Division of Cardiovascular Medicine and Department of Radiology, Division of Nuclear Medicine and Cardiothoracic Imaging, University of Michigan, Ann Arbor (V.L.M.).
Ron BlanksteinFrom the Non-Invasive Cardiovascular Imaging Program, Departments of Medicine and Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (E.H., V.A., T.V., R.K., M.F.D.C., R.B.); Cardiology Service (E.H., M.C., G.C.) and Pulmonology Service (S.P.), Division of Medicine, Walter Reed National Military Medical Center and Uniformed Services University of Health Sciences, Bethesda, MD; Center for Clinical and Epidemiological Research, University Hospital and São Paulo State Cancer Institute-University of São Paulo, Brazil (M.S.B.); Preventive Medicine Center-Hospital Israelita Albert Einstein, São Paulo, Brazil (M.S.B); Frankel Cardiovascular Center, Department of Internal Medicine, Division of Cardiovascular Medicine and Department of Radiology, Division of Nuclear Medicine and Cardiothoracic Imaging, University of Michigan, Ann Arbor (V.L.M.). rblankstein@partners.org.
Walter Reed National Military Medical Center · US

Funding

Noninvasive Cardiovascular Imaging Research Training ProgramT32HL094301 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Marcelo F DI CARLI · 2010 to 2026
$7.8M
NHLBI NIH HHS T32 HL094301
6 · The paper itself

Abstract

backgroundIndividuals with cardiac sarcoidosis have an increased risk of ventricular arrhythmia and death. Several small cohort studies have evaluated the ability of late gadolinium enhancement (LGE) by cardiac magnetic resonance imaging (MRI) to predict adverse cardiovascular events. However, studies have yielded inconsistent results, and some analyses were underpowered. Therefore, we sought to systematically review and perform meta-analysis of the prognostic value of cardiac MRI for patients with known or suspected cardiac sarcoidosis. METHODS AND

resultsWe systematically searched for cohort studies of patients with known sarcoidosis with suspected cardiac involvement who underwent cardiac MRI with LGE with at least 12 months of either prospective or retrospective follow-up data regarding post-MRI adverse cardiovascular outcomes. We identified 7 studies of 694 subjects (mean age 53; 42% men).One hundred and ninety-nine patients (29%) were LGE positive. All-cause mortality occurred in 19 LGE-positive versus 17 LGE-negative subjects (annualized incidence, 3.1% versus 0.6%). The pooled relative risk was 3.38 (95% confidence interval, 1.07-10.7; P=0.04). Cardiovascular mortality occurred in 10 LGE-positive versus 2 LGE-negative subjects (annualized incidence, 1.9% versus 0.3%; relative risk 10.7 [95% confidence interval, 1.34-86.3]; P=0.03). Ventricular arrhythmia occurred in 41 LGE-positive versus 0 LGE-negative subjects (annualized incidence, 5.9% versus 0%; relative risk 19.5 [95% confidence interval, 2.68-143]; P=0.003). A combined end point of death or ventricular arrhythmia occurred in 64 LGE-positive versus 18 LGE-negative subjects (annualized incidence, 8.8% versus 0.6%; relative risk 6.20 [95% confidence interval, 2.47-15.6]; P<0.001). There was no significant heterogeneity for any outcomes.

conclusionsLGE is associated with future cardiovascular death and ventricular arrhythmia among patients referred to MRI for known or suspected cardiac sarcoidosis.

Indexed as

Magnetic Resonance ImagingVentricular FunctionArrhythmias, CardiacCardiomyopathiesChi-Square DistributionContrast MediaDeath, Sudden, CardiacDisease ProgressionFemaleGadoliniumHumansMaleMiddle AgedMyocardiumOdds RatioPredictive Value of TestsContrast MediaGadoliniumcardiac arrhythmiacardiomyopathiesheart conduction systemmagnetic resonance imagingsarcoidosis

Identifiers

PMID27621357
PMCPMC5449111
OpenAlexW2624316857

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.