Evidence map›Paper›PMID 27621312›Full record

ArticleThe Journal of biological chemistry2016

Cardiac Ryanodine Receptor (Ryr2)-mediated Calcium Signals Specifically Promote Glucose Oxidation via Pyruvate Dehydrogenase.

Michael J Bround, Rich Wambolt, Haoning Cen, Parisa Asghari, Razvan F Albu, Jun Han, Donald McAfee, Marc Pourrier, Nichollas E Scott, Lubos Bohunek and 10 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Transcriptome analysis of effects ofOpen medicine (Warsaw, Poland) · 2024
    Article
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  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Mitochondrial NADAntioxidants & redox signaling · 2019
    Review
  18. Article
  19. Article
  20. Loss of Metabolic Flexibility in the Failing Heart.Frontiers in cardiovascular medicine · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 5 institutions in 4 countries.

Michael J BroundFrom the Cardiovascular Research Group, Life Sciences Institute and.
Rich WamboltFrom the Cardiovascular Research Group, Life Sciences Institute and.
Haoning CenFrom the Cardiovascular Research Group, Life Sciences Institute and.
Parisa AsghariFrom the Cardiovascular Research Group, Life Sciences Institute and.
Razvan F AlbuBiochemistry and Molecular Biology, and.
Jun Hanthe University of Victoria-Genome British Columbia Proteomics Centre, Victoria, British Columbia V8Z 7X8, and.
Donald McAfeeFrom the Cardiovascular Research Group, Life Sciences Institute and.
Marc PourrierFrom the Cardiovascular Research Group, Life Sciences Institute and.
Nichollas E ScottBiochemistry and Molecular Biology, and.
Lubos Bohunekthe Department of Pathology and Laboratory Medicine, University of British Columbia and the Centre for Heart and Lung Innovation, St. Paul's Hospital, Vancouver, British Columbia V6Z 1Y6.
Jerzy E KulpaBiochemistry and Molecular Biology, and.
S R Wayne Chenthe Libin Cardiovascular Institute of Alberta, Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta T2N 2T9, Canada.
David FedidaFrom the Cardiovascular Research Group, Life Sciences Institute and.
Roger W BrownseyBiochemistry and Molecular Biology, and.
Christoph H Borchersthe University of Victoria-Genome British Columbia Proteomics Centre, Victoria, British Columbia V8Z 7X8, and.
Leonard J FosterBiochemistry and Molecular Biology, and.
Thibault MayorBiochemistry and Molecular Biology, and.
Edwin D W MooreFrom the Cardiovascular Research Group, Life Sciences Institute and.
Michael F AllardFrom the Cardiovascular Research Group, Life Sciences Institute and.
James D JohnsonFrom the Cardiovascular Research Group, Life Sciences Institute and james.d.johnson@ubc.ca.ORCID http://orcid.org/0000-0002-7523-9433
University of British Columbia · CACardiovascular Institute Hospital · JPUniversity of Victoria · CAJohnson & Johnson (United States) · USUniversity of Calgary · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiac ryanodine receptor (Ryr2) Ca

Indexed as

Calcium SignalingMyocardial ContractionAnimalsCalciumGene DeletionGlucoseMetabolomeMiceMice, Inbred C57BLMyocardiumMyocytes, CardiacOxidation-ReductionProteomePyruvate Dehydrogenase ComplexPyruvatesRyanodine Receptor Calcium Release ChannelCalciumGlucoseProteomePyruvate Dehydrogenase ComplexPyruvatesryanodine receptor 2. mouseRyanodine Receptor Calcium Release Channelcalciumcalcium intracellular releasecardiac metabolismcardiomyocyteheart failureintracellular calcium releasemetabolismmetabolomicsmitochondriamitochondrial metabolismproteomicsryanodine receptortranscriptomicstricarboxylic acid cycle (TCA cycle) (Krebs cycle)

Identifiers

PMID27621312
PMCPMC5095405
OpenAlexW2548061325

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.