Evidence map›Paper›PMID 27621207›Full record

ArticleThe Journal of physiology2017

Phosphorylation regulates the sensitivity of voltage-gated Kv7.2 channels towards phosphatidylinositol-4,5-bisphosphate.

Isabella Salzer, Fatma Asli Erdem, Wei-Qiang Chen, Seok Heo, Xaver Koenig, Klaus W Schicker, Helmut Kubista, Gert Lubec, Stefan Boehm, Jae-Won Yang

Open access · hybridAbstract read
In one paragraph

Article in The Journal of physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Review
  3. Allosteric modulation of alternatively spliced CaProceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Intracellular zinc activates KCNQ channels by reducing their dependence on phosphatidylinositol 4,5-bisphosphate.Proceedings of the National Academy of Sciences of the United States of America · 2017
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Isabella SalzerDepartment of Neurophysiology and Neuropharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, 1090, Vienna, Austria.
Fatma Asli ErdemInstitute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, 1090, Vienna, Austria.
Wei-Qiang ChenDepartment of Pediatrics, Medical University of Vienna, 1090, Vienna, Austria.
Seok HeoDepartment of Pediatrics, Medical University of Vienna, 1090, Vienna, Austria.
Xaver KoenigDepartment of Neurophysiology and Neuropharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, 1090, Vienna, Austria.
Klaus W SchickerDepartment of Neurophysiology and Neuropharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, 1090, Vienna, Austria.
Helmut KubistaDepartment of Neurophysiology and Neuropharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, 1090, Vienna, Austria.
Gert LubecDepartment of Pharmaceutical Chemistry, University of Vienna, 1090, Vienna, Austria.
Stefan BoehmDepartment of Neurophysiology and Neuropharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, 1090, Vienna, Austria.
Jae-Won YangInstitute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, 1090, Vienna, Austria.
Medical University of Vienna · ATUniversity of Vienna · AT

Funding

Austrian Science Fund FWF P 23670
6 · The paper itself

Abstract

key pointsPhosphatidylinositol-4,5-bisphosphate (PIP ABSTRACT: The function of numerous ion channels is tightly controlled by G protein-coupled receptors (GPCRs). The underlying signalling mechanisms may involve phosphorylation of channel proteins and participation of phosphatidylinositol-4,5-bisphosphate (PIP

Indexed as

AnimalsAnimals, NewbornCells, CulturedKCNQ2 Potassium ChannelNeuronsPhosphatidylinositol 4,5-DiphosphatePhosphorylationRats, Sprague-DawleySuperior Cervical GanglionKCNQ2 Potassium ChannelPhosphatidylinositol 4,5-Diphosphateion channelKCNQ2phosphorylationPIP2

Identifiers

PMID27621207
PMCPMC5215842
OpenAlexW2520619796

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.