ArticleAnnals of family medicine2016
Diagnostic Accuracy of Fecal Calprotectin for Pediatric Inflammatory Bowel Disease in Primary Care: A Prospective Cohort Study.
Article in Annals of family medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Use of Laboratory Markers in Addition to Symptoms for Diagnosis of Inflammatory Bowel Disease in Children: A Meta-analysis of Individual Patient Data.JAMA pediatrics · 2017Pooled it
- Can the CalproQuest predict a positive Calprotectin test? A prospective diagnostic study.PloS one · 2019Trial
- Nasopharyngeal viral infection as a source of elevated fecal calprotectin: a diagnostic pitfall in intestinal inflammation.Gut pathogens · 2025Article
- Cytomegalovirus Detection by PCR on Fresh and Formalin-Fixed Colon Tissue Biopsies of Children with Colitis: A Prospective Cohort Study.Iranian journal of medical sciences · 2025Article
- General practitioners' experiences with chronic abdominal symptoms and a faecal calprotectin guided referral strategy in children: A Dutch qualitative study.The European journal of general practice · 2024Article
- Approach to a Child with Chronic Diarrhea.Indian journal of pediatrics · 2024Review
- Management of children with non-acute abdominal pain and diarrhea in Dutch primary care: a retrospective cohort study based on a routine primary care database (AHON).Scandinavian journal of primary health care · 2023Article
- Promoting early testing and appropriate referral to reduce diagnostic delay for children with suspected inflammatory bowel disease, a narrative review.Translational pediatrics · 2023Review
- Article
- Point-of-care faecal calprotectin testing in patients with paediatric inflammatory bowel disease during the COVID-19 pandemic.BMJ open gastroenterology · 2021Article
- Usefulness of Testing for Fecal Calprotectin in Pediatric Gastroenterology Clinical Practice.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2021Review
- Commentary-Update on disorders of the gastrointestinal tract in children, part II.Current problems in pediatric and adolescent health care · 2020Article
- Fecal Calprotectin in Combination With Standard Blood Tests in the Diagnosis of Inflammatory Bowel Disease in Children.Frontiers in pediatrics · 2020Article
- The importance of stool tests in diagnosis and follow-up of gastrointestinal disorders in children.Turk pediatri arsivi · 2019Review
- Predicting inflammatory bowel disease in children with abdominal pain and diarrhoea: calgranulin-C versus calprotectin stool tests.Archives of disease in childhood · 2018Article
- Diagnostic test strategies in children at increased risk of inflammatory bowel disease in primary care.PloS one · 2017Article
- Clinical Performance of Fecal Calprotectin Reagents Based on the Colloidal Gold Agglutination Method for Evaluating the Differential Diagnosis between Inflammatory Bowel Disease and Irritable Bowel Syndrome in Adults and Children with Gastrointestinal Symptoms (SCALE 1).Inflammatory intestinal diseasesArticle
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIn specialist care, fecal calprotectin (FCal) is a commonly used noninvasive diagnostic test for ruling out inflammatory bowel disease (IBD) in children with chronic gastrointestinal symptoms. The aim of this study was to evaluate the diagnostic accuracy of FCal for IBD in symptomatic children in primary care.
methodsWe studied 2 prospective cohorts of children with chronic diarrhea, recurrent abdominal pain, or both: children initially seen in primary care (primary care cohort) and children referred to specialist care (referred cohort). FCal (index test) was measured at baseline and compared with 1 of the 2 reference standards for IBD: endoscopic assessment or 1-year follow-up. Physicians were blinded to FCal results, and values greater than 50 μg/g feces were considered positive. We determined specificity in the primary care cohort and sensitivity in the referred cohort.
resultsNone of the 114 children in the primary care cohort ultimately received a diagnosis of IBD. The specificity of FCal in the primary care cohort was 0.87 (95% CI, 0.80-0.92). Among the 90 children in the referred cohort, 17 (19%) ultimately received a diagnosis of IBD. The sensitivity of FCal in the referred cohort was 0.99 (95% CI, 0.81-1.00).
conclusionsThe findings of this study suggest that a positive FCal result in children with chronic gastrointestinal symptoms seen in primary care is not likely to be indicative of IBD. A negative FCal result is likely to be a true negative, which safely rules out IBD in children in whom a primary care physician considers referral to specialist care.
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