Evidence map›Paper›PMID 27621104›Full record

ArticleJournal of psychiatric research2016

Social cognition in Intermittent Explosive Disorder and aggression.

Emil F Coccaro, Jennifer R Fanning, Sarah K Keedy, Royce J Lee

Registry-linked trialAbstract read
In one paragraph

Article in Journal of psychiatric research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05895513 (Effect of Pimavanserin on Aggression and Social Cognition.), which is not on this map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05895513 phase2recruitingnot on this mapstarted 2024, after this paper: background citation

Effect of Pimavanserin on Aggression and Social Cognition.

TypeinterventionalSponsorOhio State UniversityRan2024 to 2028Enrolled35ConditionsIntermittent Explosive DisorderArmsPimavanserin 34 mg, Placebo
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Article
  3. Hostile Attribution Bias Shapes Neural Synchrony in the Left Ventromedial Prefrontal Cortex during Ambiguous Social Narratives.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  4. Article
  5. Prediction of Impulsive Aggression Based on Video Images.Bioengineering (Basel, Switzerland) · 2023
    Article
  6. Article
  7. Neuronal responses in social-emotional information processing in impulsive aggressive individuals.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
    Article
  8. Article
  9. Validity and utility of Hierarchical Taxonomy of Psychopathology (HiTOP): II. Externalizing superspectrum.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2021
    Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Emil F CoccaroClinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry and Behavioral Neuroscience, The Pritzker School of Medicine, The University of Chicago, United States. Electronic address: ecoccaro@yoda.bsd.uchicago.edu.
Jennifer R FanningClinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry and Behavioral Neuroscience, The Pritzker School of Medicine, The University of Chicago, United States.
Sarah K KeedyClinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry and Behavioral Neuroscience, The Pritzker School of Medicine, The University of Chicago, United States.
Royce J LeeClinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry and Behavioral Neuroscience, The Pritzker School of Medicine, The University of Chicago, United States.
University of Chicago · US

Funding

Impulsive Aggression : A Twin Study of Behavior and 5-HTR01MH063262 · NIMH · UNIVERSITY OF CHICAGO · PI COCCARO, EMIL FRANK · 2002 to 2006
$3.1M
Neuroinflammation and AggressionR01MH104673 · NIMH · UNIVERSITY OF CHICAGO · PI COCCARO, EMIL FRANK · 2015 to 2018
$2.5M
Re-Engineering Translational Research at the University of ChicagoKL2TR000431 · NCATS · UNIVERSITY OF CHICAGO · PI SOLWAY, JULIAN · 2012 to 2016
$2.1M
Neural mechanisms mediating trauma and aggressionK23MH109824 · NIMH · UNIVERSITY OF CHICAGO · PI FANNING, JENNIFER · 2016 to 2019
$660k
NCATS NIH HHS KL2 TR000431NIMH NIH HHS K23 MH109824NIMH NIH HHS R01 MH063262NIMH NIH HHS R01 MH104673
6 · The paper itself

Abstract

Social-emotional information processing (SEIP) was assessed in individuals with current DSM-5 Intermittent Explosive Disorder (IED: n = 100) and in healthy (n = 100) and psychiatric (n = 100) controls using a recently developed and validated self-rated questionnaire. SEIP vignettes depicted both direct aggressive and relationally aggressive scenarios of a socially ambiguous nature and were followed by questions assessing subjects' reactions and judgments about the vignettes. IED subjects differed from both healthy and psychiatric controls in all SEIP components. While hostile attribution was highly related to history of aggression, it was also directly correlated with negative emotional response. Further analysis revealed that this component, as well as response valuation and response efficiency, rather than hostile attribution, best explained history of aggressive behavior. A reformulated SEIP model, including self-reported history of childhood trauma, found that negative emotional response and response efficiency were the critical correlates for history of aggressive behavior. Psychosocial interventions of aggressive behavior in IED subjects may do well to include elements that work to reduce the emotional response to social threat and that work to restructure social cognition so that the tendency towards overt, or relationally, aggressive responding is reduced.

Indexed as

Emotional IntelligenceSocial BehaviorSocial PerceptionAdultAggressionDisruptive, Impulse Control, and Conduct DisordersFemaleHumansMaleMiddle AgedPsychiatric Status Rating ScalesSelf ReportStatistics, NonparametricSurveys and QuestionnairesYoung AdultAggressionHostile attributionNegative emotionSocial emotional information processing

Identifiers

PMID27621104
PMCPMC5744876
OpenAlexW2500339156

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.