Evidence map›Paper›PMID 27621062›Full record

ArticleDevelopment (Cambridge, England)2016

Mapping lineage progression of somatic progenitor cells in the mouse fetal testis.

Chang Liu, Karina Rodriguez, Humphrey H-C Yao

Abstract read
In one paragraph

Article in Development (Cambridge, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
7.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 92 citations in OpenAlex.

  1. Article
  2. Spatiotemporally primed coelomic epithelium and supporting-like cells establish the dual origin of granulosa cells.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Sertoli cells as a hub in testicular development and male reproductive.Frontiers in cell and developmental biology · 2025
    Review
  12. Article
  13. How relevant is the mouse model for understanding human sex determination?International journal of biological sciences · 2025
    Article
  14. Fetal Leydig cells: What we know and what we don't.Molecular reproduction and development · 2024
    Review
  15. Review
  16. Article
  17. Current progress onFrontiers in cell and developmental biology · 2023
    Review
  18. Article
  19. Modeling Human Gonad Development in Organoids.Tissue engineering and regenerative medicine · 2022
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Chang LiuReproductive and Developmental Biology Group, National Institute of Environmental Health Sciences, Durham, NC 27709, USA.
Karina RodriguezReproductive and Developmental Biology Group, National Institute of Environmental Health Sciences, Durham, NC 27709, USA.
Humphrey H-C YaoReproductive and Developmental Biology Group, National Institute of Environmental Health Sciences, Durham, NC 27709, USA humphrey.yao@nih.gov.ORCID 0000-0003-2944-8469
National Institute of Environmental Health Sciences · US

Funding

Impacts of Genetic and Environmental Factors on Reproductive Organ DevelopmentZIAES102965 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI YAO, HUMPHREY · 2011 to 2025
$32.8M
NIEHS NIH HHS ZIA ES102965
6 · The paper itself

Abstract

Testis morphogenesis is a highly orchestrated process involving lineage determination of male germ cells and somatic cell types. Although the origin and differentiation of germ cells are known, the developmental course specific for each somatic cell lineage has not been clearly defined. Here, we construct a comprehensive map of somatic cell lineage progression in the mouse testis. Both supporting and interstitial cell lineages arise from WT1

Indexed as

Adult Stem CellsAnimalsCell DifferentiationGene Expression Regulation, DevelopmentalImmunohistochemistryLeydig CellsMaleMiceSertoli CellsSignal TransductionStem CellsTamoxifenTestisTranscription Factor HES-1Zinc Finger Protein GLI1Gli1 protein, mouseHes1 protein, mouseTamoxifenTranscription Factor HES-1Zinc Finger Protein GLI1HedgehogLeydig cellsLineage specificationNotchSertoli cellsTestis

Identifiers

PMID27621062
PMCPMC5087644
OpenAlexW2519395172

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.