ArticleInfection and immunity2016
Iron Homeostasis Regulates the Genotoxicity of Escherichia coli That Produces Colibactin.
Article in Infection and immunity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 53 citations in OpenAlex.
- How Klebsiella pneumoniae controls its virulence.PLoS pathogens · 2025Review
- Article
- Cyanobacterial blooms, iron, and environmental pollutants.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2024Review
- Contribution of pks+Microorganisms · 2024Review
- Current understandings of colibactin regulation.Microbiology (Reading, England) · 2024Review
- The synthesis of the novelFrontiers in microbiology · 2024Review
- D-Serine reduces the expression of the cytopathic genotoxin colibactin.Microbial cell (Graz, Austria) · 2023Article
- Escherichia coli BarA-UvrY regulates the pks island and kills Staphylococci via the genotoxin colibactin during interspecies competition.PLoS pathogens · 2022Article
- Evolution of Polymyxin Resistance Regulates Colibactin Production inACS chemical biology · 2021Article
- Shining a Light on Colibactin Biology.Toxins · 2021Review
- Review
- Article
- Oligosaccharides increase the genotoxic effect of colibactin produced by pks+ Escherichia coli strains.BMC cancer · 2021Article
- Genomic aberrations after short-term exposure to colibactin-producing E. coli transform primary colon epithelial cells.Nature communications · 2021Article
- AFrontiers in microbiology · 2021Article
- The Polyphosphate Kinase of Escherichia coli Is Required for Full Production of the Genotoxin Colibactin.mSphere · 2020Article
- YdiV regulates Escherichia coli ferric uptake by manipulating the DNA-binding ability of Fur in a SlyD-dependent manner.Nucleic acids research · 2020Article
- ClbR Is the Key Transcriptional Activator of Colibactin Gene Expression in Escherichia coli.mSphere · 2020Article
- Human Colon Mucosal Biofilms and Murine Host Communicate via Altered mRNA and microRNA Expression during Cancer.mSystems · 2020Article
- Editing of the gut microbiota reduces carcinogenesis in mouse models of colitis-associated colorectal cancer.The Journal of experimental medicine · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The genotoxin colibactin is a secondary metabolite produced by a variety of pathogenic enterobacteria. Its biosynthesis requires the enzymatic activity of the phosphopantetheinyl transferase (PPTase) ClbA. We previously showed that ClbA can also contribute to the production of siderophores. Because the biosynthesis of siderophores is regulated by iron availability, we hypothesized that iron could also modulate the production of colibactin through the transcriptional regulation of clbA This study revealed an increased transcription of clbA under iron-limiting conditions and a decrease of clbA expression in iron-rich media. We demonstrate that clbA transcription is regulated by both the ferric uptake regulator (Fur) and the small regulatory noncoding RNA RyhB. We evidenced that the regulation of the transcription of clbA by Fur and RyhB leads to the regulation of colibactin production. This work highlights the complex mechanism of regulation of an important virulence factor by the two major regulators of bacterial iron homeostasis, making iron a key environmental factor contributing to bacterial virulence and carcinogenesis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.