Evidence map›Paper›PMID 27620716›Full record

ReviewCurrent opinion in microbiology2016

Redefining the roles of the FtsZ-ring in bacterial cytokinesis.

Jie Xiao, Erin D Goley

Abstract readReview
In one paragraph

Review in Current opinion in microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Anise essential oil immobilized in chitosan microparticles: a novel bactericidal material for food protection.International microbiology : the official journal of the Spanish Society for Microbiology · 2025
    Article
  11. Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Traditional Chinese Medicine Tanreqing Targets Both Cell Division and Virulence inFrontiers in cellular and infection microbiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jie XiaoDepartment of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: xiao@jhmi.edu.
Erin D GoleyDepartment of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: egoley1@jhmi.edu.

Funding

Probing the structure, dynamics and function of the E. coli divisomeR01GM086447 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI XIAO, JIE · 2011 to 2019
$3.8M
Regulation and Mechanism of the C. Crescentus Cytokinetic RingR01GM108640 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI GOLEY, ERIN D · 2015 to 2019
$1.6M
NIGMS NIH HHS R01 GM086447NIGMS NIH HHS R01 GM108640
6 · The paper itself

Abstract

In most bacteria, cell division relies on the functions of an essential protein, FtsZ. FtsZ polymerizes at the future division site to form a ring-like structure, termed the Z-ring, that serves as a scaffold to recruit all other division proteins, and possibly generates force to constrict the cell. The scaffolding function of the Z-ring is well established, but the force generating function has recently been called into question. Additionally, new findings have demonstrated that the Z-ring is more directly linked to cell wall metabolism than simply recruiting enzymes to the division site. Here we review these advances and suggest that rather than generating a rate-limiting constrictive force, the Z-ring's function may be redefined as an orchestrator of septum synthesis.

Indexed as

CytokinesisBacteriaBacterial ProteinsCell WallCytoskeletal ProteinsEscherichia coliPeptidoglycanBacterial ProteinsCytoskeletal ProteinsFtsZ protein, BacteriaPeptidoglycan

Identifiers

PMID27620716
PMCPMC5164845

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.