Evidence map›Paper›PMID 27620496›Full record

ReviewAdvanced drug delivery reviews2017

Opportunities for new CT contrast agents to maximize the diagnostic potential of emerging spectral CT technologies.

Benjamin M Yeh, Paul F FitzGerald, Peter M Edic, Jack W Lambert, Robert E Colborn, Michael E Marino, Paul M Evans, Jeannette C Roberts, Zhen J Wang, Margaret J Wong and 1 more

Abstract readReview
In one paragraph

Review in Advanced drug delivery reviews, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Interaction of BSA with TaMolecules (Basel, Switzerland) · 2026
    Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Ultrasmall Bi/BiNanoscale advances · 2025
    Article
  12. Article
  13. Review
  14. Review
  15. Nanotheranostics: A Cutting-edge Technology for Cancer Management.Current pharmaceutical biotechnology · 2025
    Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Benjamin M YehDepartment of Radiology and Biomedical Imaging, University of California San Francisco, 505 Parnassus Ave, San Francisco, CA 94143-0628, United States. Electronic address: ben.yeh@ucsf.edu.
Paul F FitzGeraldGeneral Electric Global Research, One Research Circle, Niskayuna, NY 12309, United States.
Peter M EdicGeneral Electric Global Research, One Research Circle, Niskayuna, NY 12309, United States.
Jack W LambertDepartment of Radiology and Biomedical Imaging, University of California San Francisco, 505 Parnassus Ave, San Francisco, CA 94143-0628, United States.
Robert E ColbornGeneral Electric Global Research, One Research Circle, Niskayuna, NY 12309, United States.
Michael E MarinoGeneral Electric Global Research, One Research Circle, Niskayuna, NY 12309, United States.
Paul M EvansGE Healthcare Life Sciences, The Grove Centre, White Lion Road, Amersham, Buckinghamshire HP7 9LL, United Kingdom.
Jeannette C RobertsGeneral Electric Global Research, One Research Circle, Niskayuna, NY 12309, United States.
Zhen J WangDepartment of Radiology and Biomedical Imaging, University of California San Francisco, 505 Parnassus Ave, San Francisco, CA 94143-0628, United States.
Margaret J WongDepartment of Radiology and Biomedical Imaging, University of California San Francisco, 505 Parnassus Ave, San Francisco, CA 94143-0628, United States.
Peter J BonitatibusGeneral Electric Global Research, One Research Circle, Niskayuna, NY 12309, United States.

Funding

Nanoparticle CT Contrast Agents for Reduced Radiation Dose and New Imaging ApplicR01EB015476 · NIBIB · GENERAL ELECTRIC GLOBAL RESEARCH CTR · PI EDIC, PETER, YEH, BENJAMIN M · 2013 to 2016
$3.4M
Complementary Injectable Tungsten Contrast for Dual Contrast Dual Energy CTR21EB013816 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FU, YANJUN, YEH, BENJAMIN M · 2012 to 2013
$414k
NIBIB NIH HHS R01 EB015476NIBIB NIH HHS R21 EB013816
6 · The paper itself

Abstract

The introduction of spectral CT imaging in the form of fast clinical dual-energy CT enabled contrast material to be differentiated from other radiodense materials, improved lesion detection in contrast-enhanced scans, and changed the way that existing iodine and barium contrast materials are used in clinical practice. More profoundly, spectral CT can differentiate between individual contrast materials that have different reporter elements such that high-resolution CT imaging of multiple contrast agents can be obtained in a single pass of the CT scanner. These spectral CT capabilities would be even more impactful with the development of contrast materials designed to complement the existing clinical iodine- and barium-based agents. New biocompatible high-atomic number contrast materials with different biodistribution and X-ray attenuation properties than existing agents will expand the diagnostic power of spectral CT imaging without penalties in radiation dose or scan time.

Indexed as

Contrast MediaAnimalsHumansTomography, X-Ray ComputedContrast MediaCT contrast materialDual energy CTHeavy metal contrast materialSpectral CTX-ray contrast material

Identifiers

PMID27620496
PMCPMC5344792

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.