Evidence map›Paper›PMID 27620389›Full record

ArticleHypertension (Dallas, Tex. : 1979)2016

Activation of SIRT1 Attenuates Klotho Deficiency-Induced Arterial Stiffness and Hypertension by Enhancing AMP-Activated Protein Kinase Activity.

Diansa Gao, Zhong Zuo, Jing Tian, Quaisar Ali, Yi Lin, Han Lei, Zhongjie Sun

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed
8.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 134 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Fibulin 2 Deficiency Drives Epigenetic Hypertension.Hypertension (Dallas, Tex. : 1979) · 2026
    Article
  8. Review
  9. Serum α-Klotho and SIRT1 - Relationship with graft function, inflammation and hospitalization rates in kidney transplant recipients.Transplant international : official journal of the European Society for Organ Transplantation · 2026
    Observational
  10. Article
  11. Review
  12. Review
  13. Article
  14. Preeclampsia as a Study Model for Aging: The Klotho Gene Paradigm.International journal of molecular sciences · 2025
    Review
  15. Article
  16. Review
  17. Review
  18. Review
  19. Article
  20. Review

33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Diansa GaoFrom the Department of Cardiology (D.G., Z.Z., H.L., Z.S.) and Department of Physical Examination (J.T.), the First Affiliated Hospital, Chongqing Medical University, China; and Department of Physiology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City (D.G., Q.A., Y.L., Z.S.).
Zhong ZuoFrom the Department of Cardiology (D.G., Z.Z., H.L., Z.S.) and Department of Physical Examination (J.T.), the First Affiliated Hospital, Chongqing Medical University, China; and Department of Physiology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City (D.G., Q.A., Y.L., Z.S.).
Jing TianFrom the Department of Cardiology (D.G., Z.Z., H.L., Z.S.) and Department of Physical Examination (J.T.), the First Affiliated Hospital, Chongqing Medical University, China; and Department of Physiology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City (D.G., Q.A., Y.L., Z.S.).
Quaisar AliFrom the Department of Cardiology (D.G., Z.Z., H.L., Z.S.) and Department of Physical Examination (J.T.), the First Affiliated Hospital, Chongqing Medical University, China; and Department of Physiology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City (D.G., Q.A., Y.L., Z.S.).
Yi LinFrom the Department of Cardiology (D.G., Z.Z., H.L., Z.S.) and Department of Physical Examination (J.T.), the First Affiliated Hospital, Chongqing Medical University, China; and Department of Physiology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City (D.G., Q.A., Y.L., Z.S.).
Han LeiFrom the Department of Cardiology (D.G., Z.Z., H.L., Z.S.) and Department of Physical Examination (J.T.), the First Affiliated Hospital, Chongqing Medical University, China; and Department of Physiology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City (D.G., Q.A., Y.L., Z.S.).
Zhongjie SunFrom the Department of Cardiology (D.G., Z.Z., H.L., Z.S.) and Department of Physical Examination (J.T.), the First Affiliated Hospital, Chongqing Medical University, China; and Department of Physiology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City (D.G., Q.A., Y.L., Z.S.). zhongjie-sun@ouhsc.edu.
University of Oklahoma Health Sciences Center · US

Funding

Project 5 VEGF Signaling in PhotoreceptorsP20GM104934 · NIGMS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI LE, YUN ZHENG · 2012 to 2016
$10.8M
Investigation into Heart AgingR01AG049780 · NIA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI SUN, ZHONGJIE · 2016 to 2020
$2.4M
Regulation of Blood Pressure by KlothoR01HL102074 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI SUN, ZHONGJIE · 2011 to 2014
$2.1M
Molecular Mechanism of Kidney AgingR01DK093403 · NIDDK · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI SUN, ZHONGJIE · 2012 to 2016
$1.6M
Coupling Factor 6 in Cold-induced Kidney Dysfunction and HypertensionR01HL122166 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI SUN, ZHONGJIE · 2015 to 2018
$1.5M
Anti-aging gene klotho: a novel therapeutic target in calcific aortic valve diseaseR01HL118558 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI SUN, ZHONGJIE · 2014 to 2017
$1.5M
Investigation into Cold-induced Pulmonary Vascular Inflammation and DysfunctionR01HL116863 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI SUN, ZHONGJIE · 2013 to 2016
$1.4M
Molecular Mechanism of Arterial StiffeningR01HL105302 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI SUN, ZHONGJIE · 2010 to 2014
$1.4M
NHLBI NIH HHS R01 HL102074NHLBI NIH HHS R01 HL105302NHLBI NIH HHS R01 HL116863NHLBI NIH HHS R01 HL118558NHLBI NIH HHS R01 HL122166NIA NIH HHS R01 AG049780NIDDK NIH HHS R01 DK093403NIGMS NIH HHS P20 GM104934
6 · The paper itself

Abstract

Arterial stiffness is an independent risk factor for stroke and myocardial infarction. This study was designed to investigate the role of SIRT1, an important deacetylase, and its relationship with Klotho, a kidney-derived aging-suppressor protein, in the pathogenesis of arterial stiffness and hypertension. We found that the serum level of Klotho was decreased by ≈45% in patients with arterial stiffness and hypertension. Interestingly, Klotho haplodeficiency caused arterial stiffening and hypertension, as evidenced by significant increases in pulse wave velocity and blood pressure in Klotho-haplodeficient (KL

Indexed as

AgingAMP-Activated Protein KinasesAngiotensin IIAnimalsAortaBlotting, WesternCells, CulturedDisease Models, AnimalDown-RegulationEndothelial CellsEndothelium, VascularFemaleGlucuronidaseHeterocyclic Compounds, 4 or More RingsHumansHypertensionAMP-Activated Protein KinasesAngiotensin IIGlucuronidaseHeterocyclic Compounds, 4 or More RingsKlotho ProteinsSirt1 protein, mouseSirtuin 1SRT1720angiotensin IIarteriesblood pressureelastinhypertension

Identifiers

PMID27620389
PMCPMC5063709
OpenAlexW2530155049

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.