ArticleScientific reports2016
Vitamin B2 as a virulence factor in Pseudogymnoascus destructans skin infection.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 95 citations in OpenAlex.
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- A Palearctic view of a bat fungal disease.Conservation biology : the journal of the Society for Conservation Biology · 2025Review
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- Signals of positive selection in genomes of palearctic Myotis-bats coexisting with a fungal pathogen.BMC genomics · 2024Article
- Characterization of a High-Affinity Copper Transporter in the White-Nose Syndrome Causing Fungal PathogenbioRxiv : the preprint server for biology · 2024Article
- The skin I live in: Pathogenesis of white-nose syndrome of bats.PLoS pathogens · 2024Review
- Temporal dynamics of the bat wing transcriptome: Insight into gene-expression changes that enable protection against pathogen.Virulence · 2023Article
- Photoluminescence in mammal fur: 111 years of research.Journal of mammalogy · 2023Article
- Efficient production of bacterial antibiotics aminoriboflavin and roseoflavin in eukaryotic microorganisms, yeasts.Microbial cell factories · 2023Article
- Higher white-nose syndrome fungal isolate yields from UV-guided wing biopsies compared with skin swabs and optimal culture media.BMC veterinary research · 2023Article
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- Blood Parasites and Health Status of Hibernating and Non-Hibernating Noctule Bats (Microorganisms · 2022Article
- Biomarker Metabolites Discriminate between Physiological States of Field, Cave and White-nose Syndrome Diseased Bats.Sensors (Basel, Switzerland) · 2022Article
- Novel Photo- and Thermo-Responsive Nanocomposite Hydrogels Based on Functionalized rGO and Modified SIS/Chitosan Polymers for Localized Treatment of Malignant Cutaneous Melanoma.Frontiers in bioengineering and biotechnology · 2022Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pathogenic and non-pathogenic related microorganisms differ in secondary metabolite production. Here we show that riboflavin overproduction by a fungal pathogen and its hyperaccumulation in affected host tissue exacerbates a skin infection to necrosis. In white-nose syndrome (WNS) skin lesions caused by Pseudogymnoascus destructans, maximum riboflavin concentrations reached up to 815 μg ml(-1), indicating bioaccumulation and lack of excretion. We found that high riboflavin concentrations are cytotoxic under conditions specific for hibernation, affect bats' primary fibroblasts and induce cell detachment, loss of mitochondrial membrane potential, polymerization of cortical actin, and cell necrosis. Our results explain molecular pathology of WNS, where a skin infection becomes fatal. Hyperaccumulation of vitamin B2 coupled with reduced metabolism and low tissue oxygen saturation during hibernation prevents removal of excess riboflavin in infected bats. Upon reperfusion, oxygen reacts with riboflavin resulting in dramatic pathology after arousal. While multiple molecules enable invasive infection, riboflavin-associated extensive necrosis likely contributes to pathophysiology and altered arousal pattern in infected bats. Bioaccumulation of a vitamin under natural infection represents a novel condition in a complex host-pathogen interplay.
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