Evidence map›Paper›PMID 27619808›Full record

ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2016

Natural History After Acute Necrotizing Pancreatitis: a Large US Tertiary Care Experience.

Chandraprakash Umapathy, Amit Raina, Shreyas Saligram, Gong Tang, Georgios I Papachristou, Mordechai Rabinovitz, Jennifer Chennat, Herbert Zeh, Amer H Zureikat, Melissa E Hogg and 5 more

2 registry-linked trialsAbstract read
PubMed Publisher
In one paragraph

Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 33 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 3 pooled it
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07211568 phase3not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Effect of Pancreatic Enzyme Replacement Therapy on Nutrition in Acute Pancreatitis: A Multicenter Double Blinded Randomised Placebo Controlled Trial.

TypeinterventionalSponsorAsian Institute of Gastroenterology, IndiaRan2025 to 2027Enrolled188ConditionsAcute Pancreatitis Necrotizing, Nutrition AssessmentArmsPancreatic Enzyme Replacement Therapy, Placebo
NCT07441824 phase3recruitingnot on this mapstarted 2026, after this paper: background citation

Effect of Pancreatic Enzyme Replacement Therapy in Patients With Acute Necrotizing Pancreatitis: A Multicenter Double Blinded Randomised Placebo Controlled Trial

TypeinterventionalSponsorAsian Institute of Gastroenterology, IndiaRan2026 to 2027Enrolled140ConditionsAcute Necrotizing Pancreatitis, Pancreatic Exocrine InsufficiencyArmsPancreatic enzyme capsules, Placebo
3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 3 syntheses or guidelines pooled it, 62 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. Pancreatic enzyme replacement therapy for exocrine pancreatic insufficiency-Insights into prescribing practices.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026
    Article
  6. Review
  7. Article
  8. Long-Term All-Cause Mortality After Acute Pancreatitis: Median 7-Year Follow-Up.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2025
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Chandraprakash UmapathyDivision of General Internal Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Amit RainaDivision of Gastroenterology, Hepatology, and Nutrition, East Carolina University, Greenville, NC, USA.
Shreyas SaligramDivision of Gastroenterology, Hepatology, and Motility, University of Kansas Medical Center, Kansas City, KS, USA.
Gong TangDepartment of Biostatistics, University of Pittsburgh, Pittsburgh, PA, USA.
Georgios I PapachristouDivision of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh School of Medicine, 200 Lothrop Street, M-2, C-Wing, Pittsburgh, PA, 15213, USA.
Mordechai RabinovitzDivision of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh School of Medicine, 200 Lothrop Street, M-2, C-Wing, Pittsburgh, PA, 15213, USA.
Jennifer ChennatDivision of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh School of Medicine, 200 Lothrop Street, M-2, C-Wing, Pittsburgh, PA, 15213, USA.
Herbert ZehDivision of Surgical Oncology, University of Pittsburgh, Pittsburgh, PA, USA.
Amer H ZureikatDivision of Surgical Oncology, University of Pittsburgh, Pittsburgh, PA, USA.
Melissa E HoggDivision of Surgical Oncology, University of Pittsburgh, Pittsburgh, PA, USA.
Kenneth K LeeDivision of Surgical Oncology, University of Pittsburgh, Pittsburgh, PA, USA.
Melissa I SaulDepartment of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA, USA.
David C WhitcombDivision of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh School of Medicine, 200 Lothrop Street, M-2, C-Wing, Pittsburgh, PA, 15213, USA.
Adam SlivkaDivision of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh School of Medicine, 200 Lothrop Street, M-2, C-Wing, Pittsburgh, PA, 15213, USA.
Dhiraj YadavDivision of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh School of Medicine, 200 Lothrop Street, M-2, C-Wing, Pittsburgh, PA, 15213, USA. yadavd@upmc.edu.
University of Pittsburgh · USEast Carolina University · USMotility (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMost studies of acute necrotizing pancreatitis (ANP) focus on short-term outcomes. We evaluated long-term survival and outcomes following ANP.

methodsPatients treated for ANP at the University of Pittsburgh Medical Center from 2001 to 2008 were studied. Data on presentation and course during initial hospitalization and follow-up (median 34 months) was extracted.

resultsMean age of patients (n = 167) was 53 ± 16 years; 70 % were male, 94 % white, 71 % transfers, 52 % biliary etiology, and 78 % had first-attack of acute pancreatitis. Majority had severe disease with high Acute Physiology and Chronic Health Evaluation II (APACHE-II) score (median 11), length of stay (median 26 days), intensive care unit (ICU) admission (87 %), presence of systemic inflammatory response syndrome (SIRS) (90 %), persistent organ failure (60 %), and infected necrosis (50 %). Intervention was needed in 74 %. Eighteen (10.8 %) patients died during index hospitalization, 9 (5.4 %) during the first year, and 13 (7.8 %) after 1 year. Median survival was significantly shorter when compared with age- and sex-matched US general population (9.1 vs. 26.1 years, p < 0.001). Increasing age (HR 1.05), persistent organ failure (HR 4.5), and >50 % necrosis (HR 3.8) were independent predictors of death at 1 year. In eligible patients, new-onset diabetes, oral pancreatic enzyme replacement therapy, and disability were noted in 45, 25, and 53 %, respectively.

conclusionANP significantly impacts long-term survival. A high proportion of patients develop functional derangement and disability following ANP.

Indexed as

AdultAgedFemaleHumansMaleMiddle AgedPancreatitis, Acute NecrotizingRetrospective StudiesSurvival AnalysisTertiary Health CareTreatment OutcomeUnited StatesDisabilityEndocrine insufficiencyMortalityNecrotizingPancreatic enzyme replacement therapyPancreatitisSurvival

Identifiers

PMID27619808
OpenAlexW2520433167

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.