Evidence map›Paper›PMID 27619736›Full record

ArticleNeuroscience2017

Medullary 5-HT neurons: Switch from tonic respiratory drive to chemoreception during postnatal development.

Veronica J Cerpa, Yuanming Wu, Eduardo Bravo, Frida A Teran, Rachel S Flynn, George B Richerson

Abstract read
In one paragraph

Article in Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Seizures Cause Prolonged Impairment of Ventilation, COThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Perinatal Hypoxemia and Oxygen Sensing.Comprehensive Physiology · 2021
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Veronica J CerpaDepartment of Neurology, Yale University, New Haven, CT 06510, United States; Department of Neurology, University of Iowa, Iowa City, IA 52242, United States.
Yuanming WuDepartment of Neurology, Yale University, New Haven, CT 06510, United States; Department of Neurology, University of Iowa, Iowa City, IA 52242, United States.
Eduardo BravoDepartment of Neurology, University of Iowa, Iowa City, IA 52242, United States. Electronic address: eduardo-bravo@uiowa.edu.
Frida A TeranDepartment of Neurology, University of Iowa, Iowa City, IA 52242, United States.
Rachel S FlynnDepartment of Neurology, Yale University, New Haven, CT 06510, United States.
George B RichersonDepartment of Neurology, Yale University, New Haven, CT 06510, United States; Department of Neurology, University of Iowa, Iowa City, IA 52242, United States; Department of Molecular Physiology & Biophysics, University of Iowa, Iowa City, IA 52242, United States; Veterans Affairs Medical Center, Iowa City, IA 52242, United States.
University of Iowa · USVeterans Health Administration · USYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
VENTRAL MEDULLA, BREATHING, AND CENTRAL CHEMORECEPTIONP01HD036379 · NICHD · HARVARD MEDICAL SCHOOL · PI KINNEY, HANNAH CHASE · 1998 to 2017
$32.2M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007337 · NIGMS · UNIVERSITY OF IOWA · PI GEYER, PAMELA K., LENTZ, STEVEN R · 1985 to 2020
$15.9M
SUDEP Research Alliance: Respiratory and Arousal Mechanisms, Application 5 of 7U01NS090414 · NINDS · UNIVERSITY OF IOWA · PI RICHERSON, GEORGE B · 2014 to 2018
$3.3M
Developmental defects in serotonin neurons and the response to O2 and CO2R01HD052772 · NICHD · YALE UNIVERSITY · PI RICHERSON, GEORGE B · 2007 to 2011
$1.6M
PREDICTIVE GENES, MECHANISMS, AND CLINICAL BIOMARKERS OF SUDEPP20NS076916 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI NOEBELS, JEFFREY · 2011 to 2013
$1.4M
NCATS NIH HHS UL1 TR001863NICHD NIH HHS P01 HD036379NICHD NIH HHS R01 HD052772NIGMS NIH HHS T32 GM007337NINDS NIH HHS P20 NS076916NINDS NIH HHS U01 NS090414
6 · The paper itself

Abstract

Serotonin (5-HT) neurons contribute to respiratory chemoreception in adult mice, but it is unclear whether they play a similar role in neonatal mice. We studied breathing during development in Lmx1b

Indexed as

RespirationAcidosisAction PotentialsAnimalsAnimals, NewbornCarbon DioxideCells, CulturedChemoreceptor CellsHypoxiaLIM-Homeodomain ProteinsMedulla OblongataMice, TransgenicPatch-Clamp TechniquesPlethysmography, Whole BodySerotonergic NeuronsSerotoninCarbon DioxideLIM homeobox transcription factor 1 betaLIM-Homeodomain ProteinsSerotoninTranscription FactorschemoreceptionLmx1brespiratoryserotonin

Identifiers

PMID27619736
PMCPMC5303637
OpenAlexW2520735698

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.