ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2016
What can we infer about the origin of sex in early eukaryotes?
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Rethinking asexuality: the enigmatic case of functional sexual genes in Lepraria (Stereocaulaceae).BMC genomics · 2024Article
- Cip1, a CDK regulator, determines heterothallic mating or homothallic selfing in a protist.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- The interplay of dopamine metabolism abnormalities and mitochondrial defects in the pathogenesis of schizophrenia.Translational psychiatry · 2022Review
- Review
- Article
- The deteriorating soma and the indispensable germline: gamete senescence and offspring fitness.Proceedings. Biological sciences · 2019Article
- Article
- Response to Ghiselli FPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Article
- Mitochondrial activity in gametes and uniparental inheritance: a comment on 'What can we infer about the origin of sex in early eukaryotes?'Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Article
- Our (Mother's) Mitochondria and Our Mind.Perspectives on psychological science : a journal of the Association for Psychological Science · 2018Review
- Weird sex: the underappreciated diversity of sexual reproduction.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Article
- Life cycle strategies in free-living unicellular eukaryotes: Diversity, evolution, and current molecular tools to unravel the private life of microorganisms.The Journal of eukaryotic microbiologyReview
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Abstract
Current analysis shows that the last eukaryotic common ancestor (LECA) was capable of full meiotic sex. The original eukaryotic life cycle can probably be described as clonal, interrupted by episodic sex triggered by external or internal stressors. The cycle could have started in a highly flexible form, with the interruption of either diploid or haploid clonal growth determined by stress signals only. Eukaryotic sex most likely evolved in response to a high mutation rate, arising from the uptake of the endosymbiont, as this (proto) mitochondrion generated internal reactive oxygen species. This is consistent with the likely development of full meiotic sex from a diverse set of existing archaeal (the host of the endosymbiont) repair and signalling mechanisms. Meiotic sex could thus have been one of the fruits of symbiogenesis at the basis of eukaryotic origins: a product of the merger by which eukaryotic cells arose. Symbiogenesis also explains the large-scale migration of organellar DNA to the nucleus. I also discuss aspects of uniparental mitochondrial inheritance and mitonuclear interactions in the light of the previous analysis.This article is part of the themed issue 'Weird sex: the underappreciated diversity of sexual reproduction'.
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