Evidence map›Paper›PMID 27619680›Full record

ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2016

Bone marrow-derived mesenchymal stem cells increase drug resistance in CD133-expressing gastric cancer cells by regulating the PI3K/AKT pathway.

Nuo Ji, Ji-Wei Yu, Xiao-Chun Ni, Ju-Gang Wu, Shou-Lian Wang, Bo-Jian Jiang

Abstract read
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In one paragraph

Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.9field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Nuo JiDepartment of General Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Mohe Rd 280, Shanghai, 201900, People's Republic of China.
Ji-Wei YuDepartment of General Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Mohe Rd 280, Shanghai, 201900, People's Republic of China.
Xiao-Chun NiDepartment of General Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Mohe Rd 280, Shanghai, 201900, People's Republic of China.
Ju-Gang WuDepartment of General Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Mohe Rd 280, Shanghai, 201900, People's Republic of China.
Shou-Lian WangDepartment of General Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Mohe Rd 280, Shanghai, 201900, People's Republic of China.
Bo-Jian JiangDepartment of General Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Mohe Rd 280, Shanghai, 201900, People's Republic of China. jiang-bj2102@hotmail.com.
Shanghai Ninth People's Hospital · CNShanghai Jiao Tong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bone marrow-derived mesenchymal stem cells (BM-MSCs) are recruited to primary tumours to compose the tumour microenvironment. In various cancers, CD133-positive cells have been shown to possess cancer stem cell properties that confer chemoresistance. This study aimed to investigate the role of BM-MSCs in the anti-tumour drug resistance of CD133-expressing gastric cancer cells and explore the underlying mechanisms that governing this role. We found that CD133

Indexed as

Drug Resistance, NeoplasmAC133 AntigenAnimalsAntineoplastic AgentsApoptosisBlotting, WesternBone MarrowCell ProliferationCoculture TechniquesGene Expression Regulation, NeoplasticHumansImmunoenzyme TechniquesMaleMesenchymal Stem CellsMiceMice, Inbred BALB CAC133 AntigenAntineoplastic AgentsPhosphatidylinositol 3-KinasesPROM1 protein, humanProto-Oncogene Proteins c-aktRNA, MessengerApoptosisCancer stem cellsCD133Drug resistanceGastric cancerMesenchymal stem cells

Identifiers

PMID27619680
OpenAlexW2519432243

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.