ReviewClinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases2016
Therapeutic manipulation of the microbiota: past, present, and considerations for the future.
Review in Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Physical activity, sedentary behavior and microbiome: A systematic review and meta-analysis.Journal of science and medicine in sport · 2024Pooled it
- Clinical efficacy of fecal microbiota transplantation for patients with small intestinal bacterial overgrowth: a randomized, placebo-controlled clinic study.BMC gastroenterology · 2021Trial
- Fecal microbiota transplantation: from empirical remedy to precision medicine.Frontiers in microbiomes · 2026Review
- Understanding the intricate interactions between microbiota and host.World journal of experimental medicine · 2025Review
- A review of emerging technologies, nutritional practices, and management strategies to improve intramuscular fat composition in beef cattle.Animal biotechnology · 2024Review
- Healthcare-associated infections in adult intensive care unit patients: Changes in epidemiology, diagnosis, prevention and contributions of new technologies.Intensive & critical care nursing · 2022Article
- Exploratory studies of oral and fecal microbiome in healthy human aging.Frontiers in aging · 2022Article
- Fecal Microbiota Transplantation: What's New?Microorganisms · 2021Article
- Polymer and Crosslinker Content Influences Performance of Encapsulated Live Biotherapeutic Products.Cellular and molecular bioengineering · 2021Article
- Interplay between the Gut Microbiota and Inflammatory Mediators in the Development of Colorectal Cancer.Cancers · 2021Review
- Kin selection explains the evolution of cooperation in the gut microbiota.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Exploring the Gut-Brain Axis for the Control of CNS Inflammatory Demyelination: Immunomodulation byFrontiers in immunology · 2021Review
- Antibiotic Resistance: One Health One World Outlook.Frontiers in cellular and infection microbiology · 2021Review
- Polymeric Films for the Encapsulation, Storage, and Tunable Release of Therapeutic Microbes.Advanced healthcare materials · 2020Article
- Crosstalk Between the Gut Microbiome and Bioactive Lipids: Therapeutic Targets in Cognitive Frailty.Frontiers in nutrition · 2020Review
- Nanotechnology intervention of the microbiome for cancer therapy.Nature nanotechnology · 2019Review
- Decoding the microbiome for the development of translational applications: Overview, challenges and pitfalls.Journal of biosciences · 2019Review
- Understanding and Engineering Distributed Biochemical Pathways in Microbial Communities.Biochemistry · 2019Review
- Harnessing the microbiota to treat neurological diseases .Dialogues in clinical neuroscience · 2019Review
- Nasopharyngeal Lactobacillus is associated with a reduced risk of childhood wheezing illnesses following acute respiratory syncytial virus infection in infancy.The Journal of allergy and clinical immunology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
backgroundThe growing appreciation of the potential role of indigenous microbiota in disease has resulted in a concomitant interest in manipulating the microbiome for therapeutic effect. The most successful example of microbiota manipulation for treatment of a disease is in recurrent infection with the bacterial pathogen Clostridium difficile.
aimsThis review provides historic perspectives on development of microbiota transplantation and reviews evidence for its use in recurrent C. difficile infection. SOURCES: A PubMed search of the terms ([fecal transplant OR fecal transplantation] AND difficile) to 9 June 2016 yielded 415 articles. CONTENT: Recent work has pointed to potential mechanisms by which microbiota restoration in the form of faecal transplantation has been efficacious. This includes studies of microorganisms associated with successful faecal transplantation in human and animal studies and a focus on bacterial bile acid metabolism as a mechanism that mediates colonization resistance against the pathogen. The potential use of microbiota manipulation for other diseases such as inflammatory bowel diseases and metabolic disorders will be discussed. The case will be made that the lessons learned from treatment of recurrent C. difficile infection may not necessarily translate to use of faecal transplantation or other methods to alter the microbiome for the treatment of other diseases. IMPLICATIONS: A key conclusion that can be drawn is that understanding of the precise role of the microbiota in the pathogenesis of a specific disease is necessary prior to determining if microbiota manipulation represents a novel treatment therapy.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.