ArticleNature communications2016
Central relay of bitter taste to the protocerebrum by peptidergic interneurons in the Drosophila brain.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 54 citations in OpenAlex.
- A Tale of Two States: Similarities and Differences in Neuropeptide Signaling in Larval and Adult Drosophila.The Journal of comparative neurology · 2026Review
- Article
- A brief history of insect neuropeptide and peptide hormone research.Cell and tissue research · 2025Review
- Article
- Article
- A Neuropeptide Signaling Network That Regulates Developmental Timing and Systemic Growth in Drosophila.The Journal of comparative neurology · 2024Article
- A STIM dependent dopamine-neuropeptide axis maintains the larval drive to feed and grow in Drosophila.PLoS genetics · 2023Article
- Insect PRXamides: Evolutionary Divergence, Novelty, and Loss in a Conserved Neuropeptide System.Journal of insect science (Online) · 2023Article
- The chemosensory system of theFly · 2022Review
- Endocrine cybernetics: neuropeptides as molecular switches in behavioural decisions.Open biology · 2022Review
- Article
- Leucokinin and Associated Neuropeptides Regulate Multiple Aspects of Physiology and Behavior inInternational journal of molecular sciences · 2021Review
- Hormonal axes in Drosophila: regulation of hormone release and multiplicity of actions.Cell and tissue research · 2020Review
- Metabolism and growth adaptation to environmental conditions in Drosophila.Cellular and molecular life sciences : CMLS · 2020Review
- Neuromedin U signaling regulates retrieval of learned salt avoidance in a C. elegans gustatory circuit.Nature communications · 2020Article
- Neural basis of hunger-driven behaviour in Drosophila.Open biology · 2019Review
- Convergence of monosynaptic and polysynaptic sensory paths onto common motor outputs in aeLife · 2018Article
- Neuropeptide Mapping of Dimmed Cells of Adult Drosophila Brain.Journal of the American Society for Mass Spectrometry · 2018Article
- Functional architecture of reward learning in mushroom body extrinsic neurons of larval Drosophila.Nature communications · 2018Article
- Diversity of Internal Sensory Neuron Axon Projection Patterns Is Controlled by the POU-Domain Protein Pdm3 inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bitter is a taste modality associated with toxic substances evoking aversive behaviour in most animals, and the valence of different taste modalities is conserved between mammals and Drosophila. Despite knowledge gathered in the past on the peripheral perception of taste, little is known about the identity of taste interneurons in the brain. Here we show that hugin neuropeptide-containing neurons in the Drosophila larval brain are necessary for avoidance behaviour to caffeine, and when activated, result in cessation of feeding and mediates a bitter taste signal within the brain. Hugin neuropeptide-containing neurons project to the neurosecretory region of the protocerebrum and functional imaging demonstrates that these neurons are activated by bitter stimuli and by activation of bitter sensory receptor neurons. We propose that hugin neurons projecting to the protocerebrum act as gustatory interneurons relaying bitter taste information to higher brain centres in Drosophila larvae.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.