Evidence map›Paper›PMID 27619338›Full record

ReviewNitric oxide : biology and chemistry2017

A perspective on conformational control of electron transfer in nitric oxide synthases.

Tobias M Hedison, Sam Hay, Nigel S Scrutton

Open access · hybridAbstract readReview
In one paragraph

Review in Nitric oxide : biology and chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Probing calmodulin-NO synthase interactions via site-specific infrared spectroscopy: an introductory investigation.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2024
    Article
  3. Article
  4. Article
  5. An isoform-specific pivot modulates the electron transfer between the flavin mononucleotide and heme centers in inducible nitric oxide synthase.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2020
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Tobias M HedisonManchester Institute of Biotechnology, The University of Manchester, Manchester, United Kingdom.
Sam HayManchester Institute of Biotechnology, The University of Manchester, Manchester, United Kingdom.
Nigel S ScruttonManchester Institute of Biotechnology, The University of Manchester, Manchester, United Kingdom. Electronic address: nigel.scrutton@manchester.ac.uk.
University of Manchester · GB

Funding

Biotechnology and Biological Sciences Research Council BB/H021523/1Biotechnology and Biological Sciences Research Council BB/M017702/1
6 · The paper itself

Abstract

This perspective reviews single molecule and ensemble fluorescence spectroscopy studies of the three tissue specific nitric oxide synthase (NOS) isoenzymes and the related diflavin oxidoreductase cytochrome P450 reductase. The focus is on the role of protein dynamics and the protein conformational landscape and we discuss how recent fluorescence-based studies have helped in illustrating how the nature of the NOS conformational landscape relates to enzyme turnover and catalysis.

Indexed as

NADPH-Ferrihemoprotein ReductaseNitric Oxide SynthaseProtein ConformationSpectrometry, FluorescenceNADPH-Ferrihemoprotein ReductaseNitric Oxide SynthaseCytochrome P450 reductaseDiflavin oxidoreductaseFluorescenceNitric oxide synthaseProtein dynamics

Identifiers

PMID27619338
PMCPMC5295631
OpenAlexW2519029397

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.