Evidence map›Paper›PMID 27619237›Full record

ArticleACS chemical neuroscience2016

Discovery of Stable Non-opioid Dynorphin A Analogues Interacting at the Bradykinin Receptors for the Treatment of Neuropathic Pain.

Sara M Hall, Lindsay LeBaron, Cyf Ramos-Colon, Chaoling Qu, Jennifer Yanhua Xie, Frank Porreca, Josephine Lai, Yeon Sun Lee, Victor J Hruby

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS chemical neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Sara M HallDepartment of Chemistry and Biochemistry, University of Arizona , Tucson, Arizona 85721, United States.
Lindsay LeBaronDepartment of Chemistry and Biochemistry, University of Arizona , Tucson, Arizona 85721, United States.
Cyf Ramos-ColonDepartment of Chemistry and Biochemistry, University of Arizona , Tucson, Arizona 85721, United States.
Chaoling QuDepartment of Pharmacology, University of Arizona , Tucson, Arizona 85719, United States.
Jennifer Yanhua XieDepartment of Pharmacology, University of Arizona , Tucson, Arizona 85719, United States.
Frank PorrecaDepartment of Pharmacology, University of Arizona , Tucson, Arizona 85719, United States.
Josephine LaiDepartment of Pharmacology, University of Arizona , Tucson, Arizona 85719, United States.
Yeon Sun LeeDepartment of Chemistry and Biochemistry, University of Arizona , Tucson, Arizona 85721, United States.
Victor J HrubyDepartment of Chemistry and Biochemistry, University of Arizona , Tucson, Arizona 85721, United States.
University of Arizona · US

Funding

THERAPEUTIC PROFILES OF OPIOID DELTA RECEPTORS--NEW MODALITIESP01DA006284 · NIDA · UNIVERSITY OF ARIZONA · PI HRUBY, VICTOR J · 1989 to 2015
$14.8M
NOVEL NON-PEPTIDE OPIOID LIGANDS FOR PAINR01DA013449 · NIDA · UNIVERSITY OF ARIZONA · PI HRUBY, VICTOR J · 2000 to 2015
$6.8M
NIDA NIH HHS P01 DA006284NIDA NIH HHS R01 DA013449
6 · The paper itself

Abstract

Dynorphin A (Dyn A) is a unique endogenous ligand that possesses well-known neuroinhibitory effects via opioid receptors with a preference for the kappa receptor but also neuroexcitatory effects, which cause hyperalgesia. We have shown that the neuroexcitatory effects are mediated through bradykinin (BK) receptors and that intrathecal (i.th.) administration of our lead ligand 1, [des-Arg

Indexed as

Analgesics, Non-NarcoticAnimalsBrainDisease Models, AnimalDrug DiscoveryDrug StabilityDynorphinsHumansMaleNeuralgiaProtein BindingRats, Sprague-DawleyReceptors, BradykininAnalgesics, Non-NarcoticDynorphinsReceptors, BradykininAntihyperalgesic effectBradykinin receptorsNeuropathic painNon-opioid dynorphin APeptide stabilityStructure−activity relationship

Identifiers

PMID27619237
PMCPMC5689068
OpenAlexW2519582160

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.