Evidence map›Paper›PMID 27619215›Full record

ArticleBMC research notes2016

The effect of surgical and non-surgical weight loss on N-terminal pro-B-type natriuretic peptide and its relation to obstructive sleep apnea and pulmonary function.

Anne-Marie Gabrielsen, Torbjørn Omland, Mette Brokner, Jan Magnus Fredheim, Jens Jordan, Sverre Lehmann, May Brit Lund, Jøran Hjelmesæth, Dag Hofsø

Registry-linked trialOpen access · goldAbstract readControlled Clinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC research notes, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00273104 (The Effect of Lifestyle Intervention vs Gastric Bypass on Various Comorbidities), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00273104 nacompletednot on this map

The Effect of Lifestyle Intervention vs Gastric Bypass on Various Comorbidities

TypeinterventionalSponsorThe Hospital of VestfoldRan2005 to 2017Enrolled180ConditionsObstructive Sleep Apnea, Diabetes Mellitus, HypertensionArmsBariatric surgery, Intensive lifestyle intervention
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Cardiac natriuretic peptides.Nature reviews. Cardiology · 2020
    Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Anne-Marie GabrielsenMorbid Obesity Center, Vestfold Hospital Trust, PO Box 2168, 3103, Tønsberg, Norway.
Torbjørn OmlandDivision of Medicine, Akershus University Hospital, Lørenskog, Norway.
Mette BroknerDepartment of Clinical Chemistry, Vestfold Hospital Trust, Tønsberg, Norway.
Jan Magnus FredheimMorbid Obesity Center, Vestfold Hospital Trust, PO Box 2168, 3103, Tønsberg, Norway.
Jens JordanInstitute for Clinical Pharmacology, University of Hannover, Hanover, Germany.
Sverre LehmannDepartment of Thoracic Medicine, Haukeland University Hospital, Bergen, Norway.
May Brit LundDepartment of Respiratory Medicine, Oslo University Hospital, Oslo, Norway.
Jøran HjelmesæthMorbid Obesity Center, Vestfold Hospital Trust, PO Box 2168, 3103, Tønsberg, Norway. joran.hjelmeseth@siv.no.
Dag HofsøMorbid Obesity Center, Vestfold Hospital Trust, PO Box 2168, 3103, Tønsberg, Norway.
Sykehuset i Vestfold · NOAkershus University Hospital · NOOslo University Hospital · NOUniversity of Bergen · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundObesity is a major risk factor for obstructive sleep apnea, impaired pulmonary function and heart failure, but obesity is also associated with paradoxically low levels of serum N-terminal pro-B-type natriuretic peptide (NT-proBNP). In subjects with severe obesity undergoing weight loss treatment, we assessed the associations between changes in severity of obstructive sleep apnea, pulmonary function and serum NT-proBNP levels.

methodsOne-year non-randomized controlled clinical trial. Participants, 69.6 % women, mean (SD) age 44.6 (10.8) years and body mass index (BMI) 45.1 (5.6) kg/m(2), underwent gastric bypass surgery (n = 76) or intensive lifestyle intervention (n = 63), resulting in 30 (8) % and 8 (9) % weight loss, respectively. The reference group included 30 normal weight, healthy, gender and age matched controls. Sleep recordings, arterial blood gases, pulmonary function and blood tests were assessed before and 1 year after the interventions.

resultsNT-proBNP concentrations increased significantly more after surgery than after lifestyle intervention. The post intervention values in both groups were significantly higher than in a normal weight healthy reference group. In the whole study population changes (∆) in NT-proBNP correlated significantly with changes in both BMI (r = -0.213) and apnea hypopnea index (AHI, r = -0.354). ∆NT-proBNP was, independent of age, gender and ∆BMI, associated with ∆AHI (beta -0.216, p = 0.021). ∆AHI was, independent of ∆BMI, significantly associated with changes in pO2 (beta -0.204), pCO2 (beta 0.199), forced vital capacity (beta -0.168) and forced expiratory volume first second (beta -0.160).

conclusionsGastric bypass surgery was associated with a greater increase in NT-proBNP concentrations than non-surgical weight loss treatment. Reduced AHI was, independent of weight loss, associated with increased NT-proBNP levels and improved dynamic lung volumes and daytime blood gases. Clinical Trial Registration ClinicalTrials.gov NCT00273104, retrospectively registered Jan 5, 2006 (study start Dec 2005).

Indexed as

Weight LossAdultBody Mass IndexFemaleGastric BypassHumansLife StyleLungMaleNatriuretic Peptide, BrainPeptide FragmentsRespiratory Function TestsSleep Apnea, ObstructiveNatriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)Natriuretic peptidesObesityRespirationSleep apnea

Identifiers

PMID27619215
PMCPMC5020450
OpenAlexW2520285676

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.