SynthesisBMC infectious diseases2016
The diagnostic value of cerebrospinal fluid lactate for post-neurosurgical bacterial meningitis: a meta-analysis.
Synthesis in BMC infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 47 citations in OpenAlex.
- Meta-Analytic Modeling to Define Decision Thresholds for Cerebrospinal Fluid Heparin-Binding Protein in Healthcare-Associated Ventriculitis and Meningitis.Diagnostics (Basel, Switzerland) · 2026Review
- Post epidural steroid injection complicated bacterial meningitis and brainstem stroke.Journal of family medicine and primary care · 2026Article
- Cerebrospinal Fluid and Blood Lactate and Procalcitonin for Diagnosis of Post-neurosurgical Bacterial Meningitis.Asian journal of neurosurgery · 2026Article
- Diagnostic Utility of Procalcitonin and Lactate Determination in Cerebrospinal Fluid for the Diagnosis of Neonatal Meningitis.Journal of clinical medicine · 2025Article
- Usefulness of cerebrospinal fluid presepsin (soluble CD14 subtype) as a new marker in the diagnosis of neurosurgical postoperative meningitis.Frontiers in neurology · 2024Article
- The value of elevated cerebrospinal fluid lactate concentrations in post-neurosurgical bacterial meningitis.BMC neurology · 2023Observational
- Healthcare-Associated Ventriculitis in Children during COVID-19 Pandemic: Clinical Characteristics and Outcome of a First Infection.Antibiotics (Basel, Switzerland) · 2023Article
- The Menace of Meningitis!Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2022Article
- L-lactate in cerebrospinal fluid can be used as a biomarker of encephalitis in cattle.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2020Article
- Development and verification of a discriminate algorithm for diagnosing post-neurosurgical bacterial meningitis-A multicenter observational study.Journal of clinical laboratory analysis · 2020Observational
- Longitudinal Analysis of Risk Factors for Clinical Outcomes ofInfection and drug resistance · 2020Article
- The value of cerebrospinal fluid lactate levels in diagnosing CSF infections in pediatric neurosurgical patients.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2019Article
- Cerebrospinal Fluid Lactate as an Indicator for Post-neurosurgical Bacterial Meningitis.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2019Article
- Diagnostic Approach to Health Care- and Device-Associated Central Nervous System Infections.Journal of clinical microbiology · 2018Review
- Lactate determination in pleural and abdominal effusions: a quick diagnostic marker of exudate-a pilot study.Internal and emergency medicine · 2018Article
- The preparation and clinical application of diagnostic DNA microarray for the detection of pathogens in intracranial bacterial and fungal infections.Experimental and therapeutic medicine · 2018Article
- Cerebrospinal Fluid Lactate as a Prognostic Indicator in Postneurosurgical Bacterial Meningitis and Use of Intrathecal Colistin.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2018Article
- Expression of MMP-2 and TIMP-1 in cerebrospinal fluid and the correlation with dynamic changes of serum PCT in neonatal purulent meningitis.Experimental and therapeutic medicine · 2018Article
- Cerebrospinal Fluid Presepsin As a Marker of Nosocomial Infections of the Central Nervous System: A Prospective Observational Study.Frontiers in neurology · 2018Article
- CSF in acute and chronic infectious diseases.Handbook of clinical neurology · 2017Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBacterial meningitis is not rare in post-neurosurgical patients. If patients are not treated promptly, the mortality rate can reach 20 to 50 %. The concentration of cerebrospinal fluid (CSF) lactate has been reported to be helpful in the diagnosis of bacterial meningitis; however, no systematic evaluations have investigated CSF from a postoperative perspective. In this study, we performed a systematic evaluation and meta-analysis of the efficacy of using CSF lactate concentrations in the diagnosis of post-neurosurgical bacterial meningitis.
methodWe retrieved studies that investigated the diagnostic value of CSF lactate for the diagnosis of post-neurosurgical bacterial meningitis by searching PubMed, EBSCO, the Cochrane Library and ClinicalTrials.gov. All these databases were searched from inception to November 2015. We used Quality Assessment of Diagnostic Accuracy Studies (QUADAS), a tool for the quality assessment of diagnostic accuracy, to evaluate the quality of the included studies. The Meta-DiSc 1.4 and Review Manager 5.3 software programs were used to analyze the included studies. Forest plots and summary receiver operating characteristics (SROC) curves were also drawn.
resultsFive studies, involving a total of 404 post-neurosurgical patients, were selected from 1,672 articles according to the inclusion criteria. The quality of the five included studies was assessed using QUADAS, and the related results are presented in tables. The meta-analysis revealed the following diagnostic values regarding CSF lactate for post-neurosurgical bacterial meningitis: a pooled sensitivity of 0.92 (95 % CI 0.85-0.96), a pooled specificity of 0.88 (95 % CI 0.84-0.92 with significant heterogeneity), a diagnostic odds ratio of 83.09 (95 % CI 36.83-187.46), an area under the curve (AUCSROC) of 0.9601, an SE(AUC) of 0.0122, a Q* of 0.9046 and an SE(Q*) of 0.0179.
conclusionThe meta-analysis indicated that the CSF lactate concentration has relatively high sensitivity and specificity for the diagnosis of post-neurosurgical bacterial meningitis and thus has relatively good efficacy.
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