ArticleBMC gastroenterology2016
Prevalence of medication discrepancies in patients with cirrhosis: a pilot study.
Article in BMC gastroenterology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Medicine use and medicine-related problems in patients with liver cirrhosis: a systematic review of quantitative and qualitative studies.European journal of clinical pharmacology · 2019Pooled it
- Effectiveness of patient-oriented education and medication management intervention in people with decompensated cirrhosis.Internal medicine journal · 2020Trial
- Trial
- The value of incorporating patient-consulted medication reconciliation in influencing drug-related actions in the outpatient rheumatology setting.BMC health services research · 2022Observational
- Quality standards for the management of non-alcoholic fatty liver disease (NAFLD): consensus recommendations from the British Association for the Study of the Liver and British Society of Gastroenterology NAFLD Special Interest Group.The lancet. Gastroenterology & hepatology · 2022Review
- Hepatic Encephalopathy-Related Hospitalizations in Cirrhosis: Transition of Care and Closing the Revolving Door.Digestive diseases and sciences · 2022Review
- Medication Discrepancies and Regimen Complexity in Decompensated Cirrhosis: Implications for Medication Safety.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Appropriate and Potentially Inappropriate Medication Use in Decompensated Cirrhosis.Hepatology (Baltimore, Md.) · 2021Article
- Adherence to Non-Selective Beta Blockers for Prevention of Variceal Bleeding in Cirrhotic Patients.International journal of general medicine · 2021Article
- Improving Medication-Related Outcomes in Chronic Liver Disease.Hepatology communications · 2020Review
- Adherence to Oral Nutritional Supplements After Being Discharged from the Hospital is Low but Improves Outcome in Patients with Advanced Chronic Liver Disease.Patient preference and adherence · 2020Article
- Optimizing medication management for patients with cirrhosis: Evidence-based strategies and their outcomes.Liver international : official journal of the International Association for the Study of the Liver · 2018Review
- Medication beliefs predict medication adherence in ambulatory patients with decompensated cirrhosis.World journal of gastroenterology · 2017Article
- Specific Factors That Influence Adherence to Beta Blocker Treatment in Primary Prevention of Variceal Bleeding in Cirrhotic Romanian Patients. a Proof of Concept Qualitative Study.Journal of medicine and lifeObservational
- Retrospective evaluation of medication appropriateness in older adults with hepatic cirrhosis.Science progressArticle
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCirrhosis patients are prescribed multiple medications for their liver disease and comorbidities. Discrepancies between medicines consumed by patients and those documented in the medical record may contribute to patient harm and impair disease management. The aim of the present study was to assess the magnitude and types of discrepancies among patient-reported and medical record-documented medications in patients with cirrhosis, and examine factors associated with such discrepancies.
methodsFifty patients who attended a hospital hepatology outpatient clinic were interviewed using a questionnaire composed of mixed short-response and multiple-choice questions. Patients' reported medication use was compared with documentation in the hospital medical records and pharmacy database. Medication adherence was assessed using the 8-question ©Morisky Medication Adherence Scale (MMAS-8). The multivariate logistic regression model was constructed using clinically relevant and/or statistically significant variables as determined by univariate analysis. All p-values were 2-sided (α = 0.05).
resultsTwenty-seven patients (54.0 %) had ≥1 discrepancy between reported and documented medicines. Patients with ≥1 discrepancy were older (p = 0.04) and multivariate analysis identified taking ≥5 conventional medicines or having a 'low' or 'medium' adherence ranking as independent predictors of discrepancy (adjusted OR 11.0 (95 % CI 1.8-67.4), 20.7 (95 % CI 1.3-337.7) and 49.0 (95 % CI 3.3-718.5) respectively). Concordance was highest for liver disease medicines (71.9 %) and lowest for complementary and alternative medicines (14.5 %) and respiratory medicines (0 %).
conclusionThere is significant discrepancy between sources of patient medication information within the hepatology clinic. Medication reconciliation and medicines-management intervention may address the complex relationship between medication discrepancies, number of medications and patient adherence identified in this study.
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