Evidence map›Paper›PMID 27618830›Full record

ArticleImmunologic research2017

Anti-HMGCR antibodies demonstrate high diagnostic value in the diagnosis of immune-mediated necrotizing myopathy following statin exposure.

O Shovman, B Gilburd, C Chayat, A Dortort Lazar, H Amital, M Blank, C Bentow, M Mahler, Y Shoenfeld

Abstract read
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In one paragraph

Article in Immunologic research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 40 citations in OpenAlex.

  1. Trial
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  7. Article
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  12. Review
  13. Paraneoplastic myopathy in pancreatic cancer: a case report and literature review.Journal of community hospital internal medicine perspectives · 2021
    Article
  14. Review
  15. Article
  16. Statin-Associated Autoimmune Myopathy: Current Perspectives.Therapeutics and clinical risk management · 2020
    Review
  17. Review
  18. Article
  19. Immunopathological Characterization of Muscle Biopsy Samples from Immune-Mediated Necrotizing Myopathy Patients.Medical science monitor : international medical journal of experimental and clinical research · 2018
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

O ShovmanZabludowitz Center for Autoimmune Diseases Sheba Medical Center, 52621, Tel Hashomer, Israel.
B GilburdZabludowitz Center for Autoimmune Diseases Sheba Medical Center, 52621, Tel Hashomer, Israel.
C ChayatZabludowitz Center for Autoimmune Diseases Sheba Medical Center, 52621, Tel Hashomer, Israel.
A Dortort LazarRheumatology Unit, Rabin Medical Center, Beilinson, Israel.
H AmitalZabludowitz Center for Autoimmune Diseases Sheba Medical Center, 52621, Tel Hashomer, Israel.
M BlankZabludowitz Center for Autoimmune Diseases Sheba Medical Center, 52621, Tel Hashomer, Israel.
C BentowResearch and Development, Inova Diagnostics, San Diego, CA, USA.
M MahlerResearch and Development, Inova Diagnostics, San Diego, CA, USA.
Y ShoenfeldZabludowitz Center for Autoimmune Diseases Sheba Medical Center, 52621, Tel Hashomer, Israel. shoenfel@post.tau.ac.il.
Sheba Medical Center · ILTel Aviv University · ILNova Medical (United States) · USRabin Medical Center · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anti-HMGCR antibodies represent a characteristic serological feature of statin-exposed and statin-unexposed patients with immune-mediated necrotizing myopathy (IMNM). We assessed anti-HMGCR antibodies in patients with suspected IMNM following statin exposure and patients with other autoimmune rheumatic diseases. We evaluated the presence of anti-HMGCR autoantibodies in sera samples from 13 statin-exposed patients who were suspected of having IMNM, 38 patients with different inflammatory and autoimmune rheumatic diseases and 29 healthy subjects. The autoantibodies were evaluated by two assays: a new chemiluminescence QUANTA Flash HMGCR kit utilizing BIO-FLASH system and QUANTA Lite

Indexed as

AutoantibodiesAutoimmune DiseasesBiomarkersCell Line, TumorEnzyme-Linked Immunosorbent AssayHumansHydroxymethylglutaryl-CoA Reductase InhibitorsHydroxymethylglutaryl CoA ReductasesLuminescent MeasurementsMuscular DiseasesSensitivity and SpecificityAutoantibodiesBiomarkersHMGCR protein, humanHydroxymethylglutaryl-CoA Reductase InhibitorsHydroxymethylglutaryl CoA ReductasesAnti-HMGCR antibodiesAutoantibodiesImmune-mediated necrotizing myopathy (IMNM)MyositisStatins

Identifiers

PMID27618830
OpenAlexW2511234083

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.