Evidence map›Paper›PMID 27618684›Full record

ArticleBone marrow transplantation2017

First report of pediatric hematopoietic stem cell transplantation activities in the eastern mediterranean region from 1984 to 2011: on behalf of the pediatric cancer working committee of the eastern mediterranean blood and marrow transplantation group.

A A Hussein, A A Hamidieh, A Elhaddad, M Ramzi, T B Othman, F Hussain, D Dennison, P Ahmed, M Abboud, A Al-Ahmari and 16 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Bone marrow transplantation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

A A HusseinBone Marrow and Stem Cell Transplantation Program, King Hussein Cancer Center, Amman, Jordan.
A A HamidiehHematology, Oncology and SCT Research Center, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
A ElhaddadNational Cancer Institute, Cairo University, Cairo, Egypt.
M RamziShiraz University of Medical Science, Shiraz, Islamic Republic of Iran.
T B OthmanCenter National de Greffe de Moelle Osseuse de Tunis, Tunis, Tunisia.
F HussainKing Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
D DennisonSultan Qaboos University Hospital, Muscat, Oman.
P AhmedArmed Forces Bone Marrow Transplant Center, Rawalpindi, Pakistan.
M AbboudAmerican University Beirut Medical Center, Beirut, Lebanon.
A Al-AhmariKing Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
A WahadnehQueen Rania Al-Abdullah Children Hospital-King Hussein Medical Center, Amman, Jordan.
J FathyNational Cancer Institute, Cairo University, Cairo, Egypt.
M-A BekadjaOran University-1st November Hospital, Oran, Algeria.
S Al-KindiSultan Qaboos University Hospital, Muscat, Oman.
S BenchekrounService d'Hematologie et Oncologie Pediatrique, Casablanca, Morocco.
A IbrahimMakassed General Hospital, Beirut, Lebanon.
M BehfarHematology, Oncology and SCT Research Center, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
M SamraNational Cancer Institute, Cairo University, Cairo, Egypt.
S LadebCenter National de Greffe de Moelle Osseuse de Tunis, Tunis, Tunisia.
S AdilAga Khan University Hospital, Karachi, Pakistan.
H El-SolhKing Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
M AyasKing Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
M AljurfKing Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
A GhavamzadehHematology, Oncology and SCT Research Center, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
A Al-SeraihyKing Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Pediatric Cancer Working Committee of the Eastern Mediterranean Blood and Marrow Transplantation (EMBMT) Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To describe the hematopoietic stem cell transplantation (HSCT) activities for children in the Eastern Mediterranean (EM) region, data on transplants performed for children less than 18 years of age between 1984 and 2011 in eight EM countries (Egypt, Iran, Jordan, Lebanon, Oman, Pakistan, Saudi Arabia and Tunisia) were collected. A total of 5187 transplants were performed, of which 4513 (87%) were allogeneic and 674 (13%) were autologous. Overall, the indications for transplantation were malignant diseases in 1736 (38.5%) and non-malignant in 2777 (61.5%) patients. A myeloablative conditioning regimen was used in 88% of the allografts. Bone marrow (BM) was the most frequent source of stem cells (56.2%), although an increasing use of PBSC was observed in the last decade. The stem cell source of autologous HSCT has shifted over time from BM to PBSC, and 80.9% of autologous HSCTs were from PBSCs. The donors for allogeneic transplants were matched-related in 94.5% of the cases, and unrelated transplants, mainly cord blood (99%) in 239 (5.5%) cases. This is the first report to describe the pediatric HSCT activities in EM countries. Non-malignant disorders are the main indication for allogeneic transplantation. Frequency of alternate donor transplantation is low.

Indexed as

Hematopoietic Stem Cell TransplantationTransplantation ConditioningAdolescentAllograftsChildChild, PreschoolFemaleHumansInfantMaleMediterranean RegionNeoplasmsRetrospective Studies

Identifiers

PMID27618684

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.