Evidence map›Paper›PMID 27618683›Full record

ReviewBone marrow transplantation2016

Striving to cure adult T-cell leukaemia/lymphoma: a role for allogeneic stem cell transplant?

E H Phillips, A Hodson, O Hermine, A Bazarbachi, K Cwynarski

Open access · bronzeAbstract readReview
PubMed Publisher
In one paragraph

Review in Bone marrow transplantation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 3 countries.

E H PhillipsDepartment of Haematology, University College Hospital, London, UK.
A HodsonDepartment of Haematology, Ipswich Hospital, Ipswich, UK.
O HermineDepartment of Hematology, Imagine Institute, Assistance Publique Hôpitaux de Paris, Paris Descartes University, Necker Hospital, Paris, France.
A BazarbachiDepartment of Internal Medicine, American University of Beirut, Medical Center, Beirut, Lebanon.
K CwynarskiDepartment of Haematology, University College Hospital, London, UK.
University College London · GBAmerican University of Beirut Medical Center · LBIpswich Hospital · GBUniversité Paris Cité · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adult T-cell leukaemia/lymphoma (ATL) is an aggressive HTLV-1-related malignancy, rare outside of regions where the retrovirus is endemic. Although the use of antiviral therapy has improved outcomes, particularly for indolent forms of ATL, response to combination chemotherapy is poor and outcomes for aggressive subtypes remains dismal. Consolidation with allogeneic stem cell transplant (alloSCT) has an increasing role in the management of ATL in eligible patients, offering favourable long-term remission rates. However, relatively high-transplant-related mortality and issues with donor recruitment for certain ethnicities remain problematic. In this review, we discuss the rationale for and issues surrounding alloSCT in ATL in the context of conventional and emerging therapies.

Indexed as

AdultCombined Modality TherapyHumansHuman T-lymphotropic virus 1Leukemia-Lymphoma, Adult T-CellStem Cell TransplantationTreatment Outcome

Identifiers

PMID27618683
OpenAlexW2521017514

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.