ArticleNature medicine2016
Fetal brain lesions after subcutaneous inoculation of Zika virus in a pregnant nonhuman primate.
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In one paragraph
Article in Nature medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 189 papers, 1 of them a synthesis that pooled it.
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189citing papers in PubMed, 1 pooled it
50.5field-weighted citation impact, top 1% of its field
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Who cites it
189 citing papers in PubMed, 1 synthesis or guideline pooled it, 275 citations in OpenAlex.
- Zika virus infection as a cause of congenital brain abnormalities and Guillain-Barré syndrome: From systematic review to living systematic review.F1000Research · 2018Pooled it
- A single-cell transcriptomic atlas of the pigtail macaque placenta in late gestation.BMC genomics · 2026Article
- Inapparent maternal ZIKV infection impacts fetal brain development and postnatal behavior.PLoS pathogens · 2026Article
- A single-cell transcriptomic atlas of the periventricular proliferative zone in the late gestation fetal brain in the pigtail macaque.Frontiers in neuroscience · 2026Article
- Neutrophils at the Maternal-Fetal Interface: Agents of Protection or Destruction?American journal of reproductive immunology (New York, N.Y. : 1989) · 2025Review
- Modeling Virus-Associated Central Nervous System Disease in Non-Human Primates.International journal of molecular sciences · 2025Review
- Role of non-human primate models in accelerating research and developing countermeasures against Zika virus infection.The Lancet. Microbe · 2025Review
- Granular cytoplasmic inclusions in astrocytes and microglial activation in the fetal brain of pigtail macaques in response to maternal viral infection.Acta neuropathologica communications · 2025Article
- Article
- Persistent innate immune dysfunction and ZIKV replication in the gastrointestinal tract during SIV infection in pigtail macaques.Frontiers in immunology · 2025Article
- An Overview of Zika Virus and Zika Virus Induced Neuropathies.International journal of molecular sciences · 2024Review
- Regulatory T cells restrict immunity and pathology in distal tissue sites following a localized infection.Mucosal immunology · 2024Article
- Emerging and reemerging infectious diseases: global trends and new strategies for their prevention and control.Signal transduction and targeted therapy · 2024Review
- Fetal Zika virus inoculation in macaques revealed control of the fetal viral load during pregnancy.Virology journal · 2024Article
- Ad26.M.Env ZIKV vaccine protects pregnant rhesus macaques and fetuses against Zika virus infection.NPJ vaccines · 2024Article
- Chronic innate immune impairment and ZIKV persistence in the gastrointestinal tract during SIV infection in pigtail macaques.bioRxiv : the preprint server for biology · 2024Article
- Disruption of myelin structure and oligodendrocyte maturation in a macaque model of congenital Zika infection.Nature communications · 2024Article
- Pathogenesis of viral infections during pregnancy.Clinical microbiology reviews · 2024Review
- Nonhuman primate models of pediatric viral diseases.Frontiers in cellular and infection microbiology · 2024Review
- Insights into Zika Virus Pathogenesis and Potential Therapeutic Strategies.Biomedicines · 2023Review
129 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
32 authors at 4 institutions in 1 country.
Kristina M Adams WaldorfDepartment of Obstetrics and Gynecology, University of Washington, Seattle, Washington, USA.
Jennifer E Stencel-BaerenwaldDepartment of Immunology, University of Washington, Seattle, Washington, USA.
Raj P KapurDepartment of Pathology, University of Washington, Seattle, Washington, USA.
Colin StudholmeDepartment of Pediatrics, University of Washington, Seattle, Washington, USA.
Erica BoldenowDepartment of Pediatrics, University of Washington, Seattle, Washington, USA.
Jay VornhagenCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA.
Audrey BaldessariWashington National Primate Research Center, Seattle, Washington, USA.
Manjiri K DigheDepartment of Radiology, University of Washington, Seattle, Washington, USA.
Jeff ThielDepartment of Radiology, University of Washington, Seattle, Washington, USA.
Sean MerillatCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA.
Blair ArmisteadCenter for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA.
Jennifer Tisoncik-GoDepartment of Immunology, University of Washington, Seattle, Washington, USA.
Richard R GreenDepartment of Immunology, University of Washington, Seattle, Washington, USA.
Michael A DavisDepartment of Immunology, University of Washington, Seattle, Washington, USA.
Elyse C DeweyDepartment of Immunology, University of Washington, Seattle, Washington, USA.
Marian R FairgrieveDepartment of Immunology, University of Washington, Seattle, Washington, USA.
J Christopher GatenbyDepartment of Radiology, University of Washington, Seattle, Washington, USA.
Todd RichardsDepartment of Radiology, University of Washington, Seattle, Washington, USA.
Gwenn A GardenDepartment of Pathology, University of Washington, Seattle, Washington, USA.
Michael S DiamondDepartment of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Sandra E JuulDepartment of Pediatrics, University of Washington, Seattle, Washington, USA.ORCID 0000-0002-6861-6229
Richard F GrantWashington National Primate Research Center, Seattle, Washington, USA.
LaRene KullerWashington National Primate Research Center, Seattle, Washington, USA.
Dennis W W ShawDepartment of Radiology, University of Washington, Seattle, Washington, USA.
Jason OgleWashington National Primate Research Center, Seattle, Washington, USA.
G Michael GoughWashington National Primate Research Center, Seattle, Washington, USA.
Wonsok LeeWashington National Primate Research Center, Seattle, Washington, USA.
Chris EnglishWashington National Primate Research Center, Seattle, Washington, USA.
Robert F HevnerDepartment of Neurological Surgery, University of Washington, Seattle, Washington, USA.
William B DobynsDepartment of Pediatrics, University of Washington, Seattle, Washington, USA.
Michael GaleDepartment of Immunology, University of Washington, Seattle, Washington, USA.
Lakshmi RajagopalDepartment of Pediatrics, University of Washington, Seattle, Washington, USA.
University of Washington · USInfectious Disease Research Institute · USSeattle Children's Hospital · USWashington University in St. Louis · US
Funding
Washington National Primate Research CenterP51OD010425 · OD · UNIVERSITY OF WASHINGTON · PI Mari Ostendorf · 2012 to 2026
$201.8MWest Nile Virus and host control of innate defensesU19AI083019 · NIAID · UNIVERSITY OF WASHINGTON · PI GALE, MICHAEL · 2009 to 2018
$22.5MAntibody-based Protection against FlavivirsesR01AI073755 · NIAID · WASHINGTON UNIVERSITY · PI DIAMOND, MICHAEL S, FREMONT, DAVED H. · 2007 to 2022
$11.4MACADEMIC PEDIATRIC INFECTIOUS DISEASET32HD007233 · NICHD · SEATTLE CHILDREN'S HOSPITAL · PI KEVIN B URDAHL · 1985 to 2026
$6.7MDiseases of Public Health Importance Training GrantT32AI007509 · NIAID · UNIVERSITY OF WASHINGTON · PI LUND, JENNIFER M · 1997 to 2024
$6.3MMotion Robust Mapping of Human Brain Microstructure and Macrostructure In-UteroR01NS055064 · NINDS · UNIVERSITY OF WASHINGTON · PI STUDHOLME, COLIN · 2006 to 2017
$4.1MGBS mediated in utero fetal injuryR01AI100989 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI ADAMS WALDORF, KRISTINA M., RAJAGOPAL, LAKSHMI · 2012 to 2016
$3.9MInnate Immune Control of West Nile VirusR01AI104002 · NIAID · UNIVERSITY OF WASHINGTON · PI DIAMOND, MICHAEL S, GALE, MICHAEL · 2013 to 2017
$3.7MANTIBODY-BASED PROTECTION AGAINST FLAVIVIRUSESU01AI073755 · NIAID · WASHINGTON UNIVERSITY · PI James E Crowe, Michael S Diamond · 2024 to 2026
$3.3MMotion Robust Mapping of Human Brain Functional Connectivity Changes in UteroR01EB017133 · NIBIB · UNIVERSITY OF WASHINGTON · PI STUDHOLME, COLIN · 2013 to 2016
$2.5MMapping Patterns of Brain Tissue Growth in Premature NeonatesR01NS061957 · NINDS · UNIVERSITY OF WASHINGTON · PI STUDHOLME, COLIN · 2009 to 2013
$1.7MNIAID NIH HHS R01 AI073755NIAID NIH HHS R01 AI100989NIAID NIH HHS R01 AI104002NIAID NIH HHS T32 AI007509NIAID NIH HHS U01 AI073755NIAID NIH HHS U19 AI083019NIBIB NIH HHS R01 EB017133NICHD NIH HHS T32 HD007233NIH HHS P51 OD010425NINDS NIH HHS R01 NS055064NINDS NIH HHS R01 NS061957
Abstract
We describe the development of fetal brain lesions after Zika virus (ZIKV) inoculation in a pregnant pigtail macaque. Periventricular lesions developed within 10 d and evolved asymmetrically in the occipital-parietal lobes. Fetal autopsy revealed ZIKV in the brain and significant cerebral white matter hypoplasia, periventricular white matter gliosis, and axonal and ependymal injury. Our observation of ZIKV-associated fetal brain lesions in a nonhuman primate provides a model for therapeutic evaluation.
Indexed as
AnimalsAspartic AcidBrainCholineCreatineEchoencephalographyFemaleFetusGlutamic AcidGlutamineInositolMacaca nemestrinaMagnetic Resonance ImagingMagnetic Resonance SpectroscopyPregnancyPregnancy Complications, InfectiousAspartic AcidCholineCreatineGlutamic AcidGlutamineInositolN-acetylaspartateRNA, Viral
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.