Evidence map›Paper›PMID 27618650›Full record

ArticleNature medicine2016

The long noncoding RNA Chaer defines an epigenetic checkpoint in cardiac hypertrophy.

Zhihua Wang, Xiao-Jing Zhang, Yan-Xiao Ji, Peng Zhang, Ke-Qiong Deng, Jun Gong, Shuxun Ren, Xinghua Wang, Iris Chen, He Wang and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 239 papers.

0numbers the graph read from it
0cells of the map it votes in
239citing papers in PubMed
17.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

239 citing papers in PubMed, 387 citations in OpenAlex.

  1. Review
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  3. Cardiac epigenome in heart development and disease.Nature reviews. Cardiology · 2026
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179 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 7 institutions in 2 countries.

Zhihua WangDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.
Xiao-Jing ZhangDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.
Yan-Xiao JiDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.
Peng ZhangDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.
Ke-Qiong DengDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.
Jun GongDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.
Shuxun RenDivision of Molecular Medicine, Department of Anesthesiology, David Geffen School of Medicine, University of California at Los Angeles (UCLA), Los Angeles, California, USA.
Xinghua WangDepartment of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin, China.
Iris ChenDivision of Molecular Medicine, Department of Anesthesiology, David Geffen School of Medicine, University of California at Los Angeles (UCLA), Los Angeles, California, USA.
He WangDivision of Molecular Medicine, Department of Anesthesiology, David Geffen School of Medicine, University of California at Los Angeles (UCLA), Los Angeles, California, USA.
Chen GaoDivision of Molecular Medicine, Department of Anesthesiology, David Geffen School of Medicine, University of California at Los Angeles (UCLA), Los Angeles, California, USA.
Tomohiro YokotaDivision of Molecular Medicine, Department of Anesthesiology, David Geffen School of Medicine, University of California at Los Angeles (UCLA), Los Angeles, California, USA.
Yen Sin AngGladstone Institute of Cardiovascular Diseases, San Francisco, California, USA.
Shen LiDepartment of Medicine, Cardiology Division, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA.
Ashley CassDepartment of Integrative Biology and Physiology, College of Life Sciences, Molecular Biology Institute, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA.
Thomas M VondriskaDivision of Molecular Medicine, Department of Anesthesiology, David Geffen School of Medicine, University of California at Los Angeles (UCLA), Los Angeles, California, USA.
Guangping LiDepartment of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin, China.
Arjun DebDepartment of Medicine, Cardiology Division, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA.
Deepak SrivastavaGladstone Institute of Cardiovascular Diseases, San Francisco, California, USA.
Huang-Tian YangKey Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
Xinshu XiaoDepartment of Integrative Biology and Physiology, College of Life Sciences, Molecular Biology Institute, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA.
Hongliang LiDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.
Yibin WangDivision of Molecular Medicine, Department of Anesthesiology, David Geffen School of Medicine, University of California at Los Angeles (UCLA), Los Angeles, California, USA.
University of California, Los Angeles · USRenmin Hospital of Wuhan University · CNWuhan University · CNGladstone Institutes · USChinese Academy of Sciences · CNSecond Hospital of Tianjin Medical University · CNTianjin Medical University · CN

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
Systems Approach to Unraveling the Genetic Basis of Heart FailureR01HL114437 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DENG, MARIO C., KARMA, ALAIN S · 2013 to 2016
$4.7M
Novel mechanisms in ER regulation in heartR01HL070079 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WANG, YIBIN · 2003 to 2011
$3.2M
Epigenomic Mechanisms of Heart FailureR01HL129639 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI VONDRISKA, THOMAS M. · 2015 to 2018
$2.6M
A Systems Approach to Dissect Genetic Basis of Heart FailureR01HL123295 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LUSIS, ALDONS JAKE, WANG, YIBIN · 2014 to 2017
$2.6M
UCLA Dentist-Scientist and Oral Health-Researcher Training ProgramT90DE022734 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WONG, DAVID T · 2012 to 2017
$2.3M
Role of ABCC6 in cardivascular calcificationR01HL137241 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DEB, ARJUN · 2017 to 2020
$2.1M
Systems Analysis of Cardiac Chromatin StructureR01HL115238 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI VONDRISKA, THOMAS M. · 2012 to 2016
$1.9M
Novel Mechanism of SR Calcium Regulation in Cardiac DysfunctionR01HL108186 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WANG, YIBIN · 2011 to 2015
$1.9M
Novel Function and Regulatory Mechanisms of Stress Kinase p38 in HeartR01HL103205 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WANG, YIBIN · 2010 to 2014
$1.9M
Role of mesenchymal-endothelial-transition in cardiac hypertrophyR01HL129178 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DEB, ARJUN · 2015 to 2018
$1.5M
Novel Regulatory Circuit in Cardiac Hypertrophy Via RNA SplicingR01HL122737 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WANG, YIBIN · 2014 to 2017
$1.5M
NCATS NIH HHS UL1 TR000124NHGRI NIH HHS R01 HG006264NHGRI NIH HHS U01 HG007013NHLBI NIH HHS R01 HL070079NHLBI NIH HHS R01 HL103205NHLBI NIH HHS R01 HL108186NHLBI NIH HHS R01 HL114437NHLBI NIH HHS R01 HL115238NHLBI NIH HHS R01 HL122737NHLBI NIH HHS R01 HL123295NHLBI NIH HHS R01 HL129178NHLBI NIH HHS R01 HL129639NHLBI NIH HHS R01 HL137241NHLBI NIH HHS R21 HL110667NIDCR NIH HHS T90 DE022734
6 · The paper itself

Abstract

Epigenetic reprogramming is a critical process of pathological gene induction during cardiac hypertrophy and remodeling, but the underlying regulatory mechanisms remain to be elucidated. Here we identified a heart-enriched long noncoding (lnc)RNA, named cardiac-hypertrophy-associated epigenetic regulator (Chaer), which is necessary for the development of cardiac hypertrophy. Mechanistically, Chaer directly interacts with the catalytic subunit of polycomb repressor complex 2 (PRC2). This interaction, which is mediated by a 66-mer motif in Chaer, interferes with PRC2 targeting to genomic loci, thereby inhibiting histone H3 lysine 27 methylation at the promoter regions of genes involved in cardiac hypertrophy. The interaction between Chaer and PRC2 is transiently induced after hormone or stress stimulation in a process involving mammalian target of rapamycin complex 1, and this interaction is a prerequisite for epigenetic reprogramming and induction of genes involved in hypertrophy. Inhibition of Chaer expression in the heart before, but not after, the onset of pressure overload substantially attenuates cardiac hypertrophy and dysfunction. Our study reveals that stress-induced pathological gene activation in the heart requires a previously uncharacterized lncRNA-dependent epigenetic checkpoint.

Indexed as

AnimalsBlotting, NorthernCardiomegalyChromatin ImmunoprecipitationComputer SimulationEchocardiographyEpigenesis, GeneticGene Expression ProfilingGene Knockdown TechniquesHeartHistone CodeHumansImmunoblottingInduced Pluripotent Stem CellsIn Situ Hybridization, FluorescenceIn Vitro TechniquesMechanistic Target of Rapamycin Complex 1Multiprotein ComplexesPolycomb Repressive Complex 2RNA, Long NoncodingTOR Serine-Threonine Kinases

Identifiers

PMID27618650
PMCPMC5053883
OpenAlexW2520561563

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.