ReviewThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2016
The Depressed Frail Phenotype: The Clinical Manifestation of Increased Biological Aging.
Review in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
66 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Frail Depressed Patient: A Narrative Review on Treatment Challenges.Clinical interventions in aging · 2022Pooled it
- Epigenetic aging and DNA methylation biomarker changes following ketamine treatment in patients with MDD and PTSD: a pilot study.Translational psychiatry · 2025Trial
- Psilocybin therapy for mood dysfunction in Parkinson's disease: an open-label pilot trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Trial
- RETRACTED: Effects of L-DOPA Monotherapy on Psychomotor Speed and [Biological psychiatry · 2019Trial
- Beyond the Association: Unpacking the Bidirectional Dynamics and Clinical Nuances of Depression and Frailty in Acutely Hospitalized Older Adults.Geriatrics & gerontology international · 2026Article
- A High Geriatric Depression Scale Score on Admission to Hospital Predicts a Worse Clinical Frailty Scale Score After Discharge.Geriatrics & gerontology international · 2026Article
- Habitual Tea Consumption Is Associated with a Low Prevalence of Self-Reported Lifetime History of Depression in Taiwanese Population Study.Nutrients · 2026Article
- The association of depressive symptoms and dietary inflammatory index with frailty in older adults with diabetes.BMC psychiatry · 2026Article
- Molecular Mechanisms of Accelerated Ageing in Geriatric Depression: Interplay of Telomere Attrition, Mitochondrial Dysfunction and Cellular Senescence.International journal of molecular sciences · 2026Review
- Bidirectional causal association between frailty and six psychiatric disorders.European archives of psychiatry and clinical neuroscience · 2026Article
- Frailty and [Theranostics · 2026Review
- Joint trajectories of frailty and depressive symptoms and risk of incident osteoarthritis in middle-aged and older adults.Frontiers in public health · 2026Article
- Montreal Cognitive Assessment (MoCA) Norms for Older Patients with a Depressive Disorder.Medical sciences (Basel, Switzerland) · 2025Article
- Psychedelic interventions for major depressive disorder in the elderly: Exploring novel therapies, promise and potential.Dialogues in clinical neuroscience · 2025Review
- Suicide in later life: the role of frailty and depression.Current opinion in psychiatry · 2025Review
- Transition and dynamic reconfiguration in late-life depression based on hidden Markov model.Npj mental health research · 2025Article
- Associations of life's crucial 9 with mortality among older adults with frailty: a prospective cohort study from the NHANES 2007 to 2018.BMC geriatrics · 2025Article
- Predictors of independence in older people: A longitudinal, population-based study using the CARE75 + cohort.BMC geriatrics · 2025Article
- The Interaction Among Depressive Symptoms, Pain, and Frailty in Middle-Aged and Older Adults: A Longitudinal Cross-Lagged Panel Analysis.Depression and anxiety · 2025Article
- Interrelationships of frailty, hemoglobin, cognition, and depressive symptoms in aging: a path analysis of the ELSI-Brazil study.Cadernos de saude publica · 2025Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Depression in later life is a severe public health problem, associated with higher rates of mortality, suicide, and dementia. Effectiveness of treatment is limited by the failure to deconstruct the heterogeneity of the illness and because diagnostic criteria, pathophysiological models, and treatment algorithms for depression are primarily based on studies of younger adults even though symptoms of the illness and physiology of the patient change with age. Thus, understanding how aging interacts with depressive illness may elucidate endophenotypes of late-life depression with different clinical manifestations and underlying mechanisms that can then be targeted with more personalized approaches to treatment. This paper proposes a model for the critical confluence between depression and frailty, a high-risk morbidity and mortality syndrome of later life. This model hypothesizes that characteristics of frailty in adults with late life depression represent the clinical manifestation of greater biological aging and their presence in the context of a depressive illness exposes elders to deleterious trajectories. Potential common biological substrates that may result in the manifestation of the depressed frail phenotype including mitochondrial functioning, dopaminergic neurotransmission, and inflammatory processes and implications for the assessment and treatment of adults with late-life depression are discussed. As society continues to live longer, the preservation of the quality of these added years becomes paramount, and the combined impact of depression and frailty on the preservation of this quality warrants the attention of clinical researchers and physicians.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.