ArticlePLoS genetics2016
The Multivesicular Bodies (MVBs)-Localized AAA ATPase LRD6-6 Inhibits Immunity and Cell Death Likely through Regulating MVBs-Mediated Vesicular Trafficking in Rice.
Article in PLoS genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 75 citations in OpenAlex.
- Lesion Mimic Mutant: An Ideal Genetic Material for Deciphering the Balance Between Plant Immunity and Growth.Rice (New York, N.Y.) · 2025Review
- Proteomic Dynamics in the Interaction of Susceptible and Resistant Tomato Cultivars and Potato Cyst Nematodes.International journal of molecular sciences · 2025Article
- H₂O₂ regulates rice defense via bHLH25 oxidation.Cell research · 2025Article
- Rice transcription factor bHLH25 confers resistance to multiple diseases by sensing HCell research · 2025Article
- A single amino acid substitution in the AAA-type ATPase LRD6-6 activates immune responses but decreases grain quality in rice.Frontiers in plant science · 2024Article
- Disruption of the Novel Small Protein RBR7 Leads to Enhanced Plant Resistance to Blast Disease.Rice (New York, N.Y.) · 2023Article
- OsGLP3-7 positively regulates rice immune response by activating hydrogen peroxide, jasmonic acid, and phytoalexin metabolic pathways.Molecular plant pathology · 2023Article
- Vesicle trafficking in rice: too little is known.Frontiers in plant science · 2023Review
- LIP5, a MVB biogenesis regulator, is required for rice growth.Frontiers in plant science · 2023Article
- Natural immunity stimulation using ELICE16INDURES® plant conditioner in field culture of soybean.Heliyon · 2023Article
- A putative SUBTILISIN-LIKE SERINE PROTEASE 1 (SUBSrP1) regulates anther cuticle biosynthesis and panicle development in rice.Journal of advanced research · 2022Article
- ATP-citrate lyase B (ACLB) negatively affects cell death and resistance to Verticillium wilt.BMC plant biology · 2022Article
- A Single Amino Acid Substitution in MIL1 Leads to Activation of Programmed Cell Death and Defense Responses in Rice.International journal of molecular sciences · 2022Article
- Deletion of Diterpenoid Biosynthetic GenesInternational journal of molecular sciences · 2022Article
- Disruption ofInternational journal of molecular sciences · 2022Article
- A conserved clathrin-coated vesicle component, OsSCYL2, regulates plant innate immunity in rice.Plant, cell & environment · 2022Article
- SDR7-6, a short-chain alcohol dehydrogenase/reductase family protein, regulates light-dependent cell death and defence responses in rice.Molecular plant pathology · 2022Article
- Role of reactive oxygen species in lesion mimic formation and conferred basal resistance toFrontiers in plant science · 2022Article
- Rice Lesion Mimic Mutants (LMM): The Current Understanding of Genetic Mutations in the Failure of ROS Scavenging during Lesion Formation.Plants (Basel, Switzerland) · 2021Review
- Genome-Wide Association Study Identified Novel Candidate Loci/Genes Affecting Lodging Resistance in Rice.Genes · 2021Article
Corrections and comments
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Authors and funding
23 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies have shown that multivesicular bodies (MVBs)/endosomes-mediated vesicular trafficking may play key roles in plant immunity and cell death. However, the molecular regulation is poorly understood in rice. Here we report the identification and characterization of a MVBs-localized AAA ATPase LRD6-6 in rice. Disruption of LRD6-6 leads to enhanced immunity and cell death in rice. The ATPase activity and homo-dimerization of LRD6-6 is essential for its regulation on plant immunity and cell death. An ATPase inactive mutation (LRD6-6E315Q) leads to dominant-negative inhibition in plants. The LRD6-6 protein co-localizes with the MVBs marker protein RabF1/ARA6 and interacts with ESCRT-III components OsSNF7 and OsVPS2. Further analysis reveals that LRD6-6 is required for MVBs-mediated vesicular trafficking and inhibits the biosynthesis of antimicrobial compounds. Collectively, our study shows that the AAA ATPase LRD6-6 inhibits plant immunity and cell death most likely through modulating MVBs-mediated vesicular trafficking in rice.
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