ArticlePLoS biology2016
Mitogen-Activated Protein Kinase Cascade MKK7-MPK6 Plays Important Roles in Plant Development and Regulates Shoot Branching by Phosphorylating PIN1 in Arabidopsis.
Article in PLoS biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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62 citing papers in PubMed, 138 citations in OpenAlex.
- Identification and fine mapping of a locus controlling multi-main-stem trait in Brassica napus.BMC plant biology · 2026Article
- Response of hidden architects to salt stress.Planta · 2025Review
- Jack of all trades: crosstalk between FERONIA signaling and hormone pathways.Journal of experimental botany · 2025Review
- First note of QTL mapping of low vigor traits using the updated F2 'Koroneiki' linkage map of olive.Frontiers in plant science · 2025Article
- Identification of mitogen-activated protein kinases substrates inPlant signaling & behavior · 2024Article
- Depletion of Gibberellin Signaling Up-RegulatesInternational journal of molecular sciences · 2024Article
- Phosphorylation of auxin signaling repressor IAA8 by heat-responsive MPKs causes defective flower development.Plant physiology · 2024Article
- Molecular traits of MAPK kinases and the regulatory mechanism of GhMAPKK5 alleviating drought/salt stress in cotton.Plant physiology · 2024Article
- Comprehensive analysis of MAPK gene family in upland cotton (Gossypium hirsutum) and functional characterization of GhMPK31 in regulating defense response to insect infestation.Plant cell reports · 2024Article
- Genome-wide identification of MAPK family in papaya (Carica papaya) and their involvement in fruit postharvest ripening.BMC plant biology · 2024Article
- Genetic regulation of lateral root development.Plant signaling & behavior · 2023Review
- Suppression ofProceedings of the National Academy of Sciences of the United States of America · 2023Article
- PacBio Full-Length Transcriptome Sequencing Reveals the Mechanism of Salt Stress Response inPlants (Basel, Switzerland) · 2023Article
- Article
- Unlocking the Multifaceted Mechanisms of Bud Outgrowth: Advances in Understanding Shoot Branching.Plants (Basel, Switzerland) · 2023Review
- Phosphorylation and ubiquitination of OsWRKY31 are integral to OsMKK10-2-mediated defense responses in rice.The Plant cell · 2023Article
- Dynamic GOLVEN-ROOT GROWTH FACTOR 1 INSENSITIVE signaling in the root cap mediates root gravitropism.Plant physiology · 2023Article
- Phosphorylation of the auxin signaling transcriptional repressor IAA15 by MPKs is required for the suppression of root development under drought stress in Arabidopsis.Nucleic acids research · 2022Article
- Conuping BSA-Seq and RNA-Seq Reveal the Molecular Pathway and Genes Associated with the Plant Height of Foxtail Millet (International journal of molecular sciences · 2022Article
- Genome-Wide Identification and Expression Analysis of MAPK Gene Family in Lettuce (International journal of molecular sciences · 2022Article
2 more citing papers are in PubMed but not listed here.
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Emerging evidences exhibit that mitogen-activated protein kinase (MAPK/MPK) signaling pathways are connected with many aspects of plant development. The complexity of MAPK cascades raises challenges not only to identify the MAPK module in planta but also to define the specific role of an individual module. So far, our knowledge of MAPK signaling has been largely restricted to a small subset of MAPK cascades. Our previous study has characterized an Arabidopsis bushy and dwarf1 (bud1) mutant, in which the MAP Kinase Kinase 7 (MKK7) was constitutively activated, resulting in multiple phenotypic alterations. In this study, we found that MPK3 and MPK6 are the substrates for phosphorylation by MKK7 in planta. Genetic analysis showed that MKK7-MPK6 cascade is specifically responsible for the regulation of shoot branching, hypocotyl gravitropism, filament elongation, and lateral root formation, while MKK7-MPK3 cascade is mainly involved in leaf morphology. We further demonstrated that the MKK7-MPK6 cascade controls shoot branching by phosphorylating Ser 337 on PIN1, which affects the basal localization of PIN1 in xylem parenchyma cells and polar auxin transport in the primary stem. Our results not only specify the functions of the MKK7-MPK6 cascade but also reveal a novel mechanism for PIN1 phosphorylation, establishing a molecular link between the MAPK cascade and auxin-regulated plant development.
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