Evidence map›Paper›PMID 27618452›Full record

SynthesisNature genetics2016

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals.

Georg B Ehret, Teresa Ferreira, Daniel I Chasman, Anne U Jackson, Ellen M Schmidt, Toby Johnson, Gudmar Thorleifsson, Jian'an Luan, Lousie A Donnelly, Stavroula Kanoni and 306 more

Open access · hybridAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 265 papers, 18 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
265citing papers in PubMed, 18 pooled it
56.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

265 citing papers in PubMed, 18 syntheses or guidelines pooled it, 435 citations in OpenAlex.

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  14. Systematic review of the evidence on the cost-effectiveness of pharmacogenomics-guided treatment for cardiovascular diseases.Genetics in medicine : official journal of the American College of Medical Genetics · 2020
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205 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

316 authors at 20 institutions in 32 countries.

Georg B Ehret *Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Teresa Ferreira *Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.
Daniel I ChasmanDivision of Preventive Medicine, Brigham and Women's Hospital, 900 Commonwealth Ave. East, Boston, MA 02215, USA.
Anne U JacksonDepartment of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA.
Ellen M SchmidtDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.
Toby JohnsonClinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, EC1M 6BQ, UK.
Gudmar ThorleifssondeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Jian'an LuanMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
Lousie A DonnellyMedical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK.
Stavroula KanoniWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Ann-Kristin PetersenInstitute of Genetic Epidemiology, Helmholtz Zentrum München, Neuherberg 85764, Germany.
Vasyl PihurCenter for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Rona J StrawbridgeCardiovascular Research Unit, Center for Molecular Medicine L8:03, Department of Medicine, Karolinska Institutet, 171 76 Stockholm, Sweden.
Dmitry ShunginDepartment of Public Health and Clinical Medicine, Umeå University, Sweden.
Maria F HughesCentre of Excellence for Public Health, Queens University Belfast, Grosvenor Road, Belfast BT126JP, UK.
Osorio MeirellesLaboratory of Genetics, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA.
Marika KaakinenDepartment of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London, UK.
Nabila Bouatia-NajiINSERM UMR970, Paris Cardiovascular Research Center PARCC, 56 rue Leblanc, 75015 Paris, France.
Kati KristianssonNational Institute for Health and Welfare, FI-00271 Helsinki, Finland.
Sonia ShahGenetic Epidemiology Group, Dept. Epidemiology and Public Health, UCL, London, WC1E 6BT, UK.
Marcus E KleberVth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany.
Xiuqing GuoInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, 1124 W. Carson Street, Torrance, CA 90502, USA.
Leo-Pekka LyytikäinenDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland.
Cristiano FavaUniversity of Lund, Dept Internal Medicine, Malmo, SE 20502, Sweden.
Niclas ErikssonUppsala University, Uppsala Clinical Research Center, SE-75185 Uppsala, Sweden.
Ilja M NolteDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.
Patrik K MagnussonDept of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, SE-171 77 Stockholm, Sweden.
Elias L SalfatiDepartment of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Loukianos S RallidisSecond Department of Cardiology, Attikon Hospital, School of Medicine, University of Athens, Athens, Greece.
Elizabeth TheuschChildren's Hospital Oakland Research Institute, Oakland, CA 94609, USA.
Andrew J P SmithDepartment of Cardiovascular Genetics, Institute of Cardiovascular Sciences, University College London, London WC1E 6JF, UK.
Lasse FolkersenCardiovascular Research Unit, Center for Molecular Medicine L8:03, Department of Medicine, Karolinska Institutet, 171 76 Stockholm, Sweden.
Kate WitkowskaClinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, EC1M 6BQ, UK.
Tune H PersDivision of Endocrinology, Boston Children's Hospital, Boston, MA 02115, USA.
Roby JoehanesNational Heart, Lung and Blood Institute's Framingham Heart Study, Framingham, MA 01702, USA.
Stuart K KimDept. Dev. Bio. And Genetics, Stanford University Medical Center, Stanford, CA 94305, USA.
Lazaros LataniotisWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Rick JansenDepartment of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands.
Andrew D JohnsonNational Heart, Lung and Blood Institute's Framingham Heart Study, Framingham, MA 01702, USA.
Helen WarrenClinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, EC1M 6BQ, UK.
Young Jin KimCenter for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
Wei ZhaoDivision of Translational Medicine and Human Genetics, Department of Medicine, University of Pennyslvania, USA.
Ying WuDepartment of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.
Bamidele O TayoDepartment of Preventive Medicine and Epidemiology, Loyola University Chicago Stritch School of Medicine, Maywood, IL, 60153, USA.
Murielle BochudInstitute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Route de la Corniche 10, 1010 Lausanne, Switzerland.
CHARGE-EchoGen consortium
CHARGE-HF consortium
Wellcome Trust Case Control Consortium
Devin AbsherHudsonAlpha Institute for Biotechnology, Huntsville, AL 35086, USA.
Linda S AdairDepartment of Nutrition, University of North Carolina, Chapel Hill, NC 27599, USA.
Najaf AminGenetic Epidemiology Unit, Department of Epidemiology, Erasmus MC, Rotterdam, 3015CN, The Netherlands.
Dan E ArkingCenter for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Tomas AxelssonUppsala University, Department of Medical Sciences, SE-75185 Uppsala, Sweden.
Damiano BaldassarreDipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano, Milan, Italy.
Beverley BalkauINSERM Centre for Research in Epidemiology and Population Health, U1018, Villejuif, France University Paris-Sud, URMS 1018, Villejuif, France.
Stefania BandinelliGeriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy.
Michael R BarnesWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Inês BarrosoWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA, Hinxton, UK.
Stephen BevanSchool of Life Science, University of Lincoln, Joseph Banks Laboratories, Lincoln LN6 7DL, UK.
Joshua C BisCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA.
Gyda BjornsdottirdeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Michael BoehnkeDepartment of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA.
Eric BoerwinkleHuman Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, 1200 Pressler St., Suite 453E, Houston, TX 77030, USA.
Lori L BonnycastleMedical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA.
Dorret I BoomsmaDepartment of Biological Psychology, VU University, Amsterdam, The Netherlands.
Stefan R BornsteinDept of Medicine III, University of Dresden, Medical Faculty Carl Gustav Carus, Fetscherstrasse 74, 01307 Dresden, Germany.
Morris J BrownThe Barts Heart Centre, William Harvey Research Institute, Queen Mary University of London, London EC1M 6BQ, UK.
Michel BurnierNephrology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Bugnon 17, 1005 Lausanne, Switzerland.
Claudia P CabreraClinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, EC1M 6BQ, UK.
John C ChambersDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London W2 1PG, UK.
I-Shou ChangNational Institute of Cancer Research, National Health Research Institutes. 35 Keyan Rd., Zhunan Town, Miaoli County 350, Taiwan.
Ching-Yu ChengSingapore Eye Research Institute, Singapore National Eye Centre, Singapore 168751, Singapore.
Peter S ChinesMedical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA.
Ren-Hua ChungDivision of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes. 35 Keyan Rd., Zhunan Town, Miaoli County 350, Taiwan.
Francis S CollinsMedical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA.
John M ConnellUniversity of Dundee, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK.
Angela DöringInstitute of Epidemiology I, Helmholtz Zentrum München, Neuherberg 85764, Germany.
Jean DallongevilleUMR744 Inserm-Lille2-Institut Pasteur Lille, France.
John DaneshDepartment of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Ulf de FaireDivision of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Graciela DelgadoVth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany.
Anna F DominiczakBHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, 126 University Place, Glasgow, G12 8QT, UK.
Alex S F DoneyMedical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK.
Fotios DrenosDepartment of Cardiovascular Genetics, Institute of Cardiovascular Sciences, University College London, London WC1E 6JF, UK.
Sarah EdkinsWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA, Hinxton, UK.
John D EicherNational Heart, Lung and Blood Institute's Framingham Heart Study, Framingham, MA 01702, USA.
Roberto ElosuaCardiovascular Epidemiology and Genetics. IMIM (Institut Hospital del Mar d'Investigacions Mèdiques), Barcelona, Spain.
Stefan EnrothDepartment of Immunology, Genetics and Pathology, University of Uppsala, Box 815, Biomerical center, 751 08 Uppsala, Sweden.
Jeanette ErdmannInstitut für Integrative und Experimentelle Genomik, Universiät zu Lübeck, RatzeburgerAllee 160, 23538 Lübeck, Germany.
Per ErikssonCardiovascular Research Unit, Center for Molecular Medicine L8:03, Department of Medicine, Karolinska Institutet, 171 76 Stockholm, Sweden.
Tonu EskoEstonian Genome Center, University of Tartu, Tartu, 51010, Estonia.
Evangelos EvangelouDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London W2 1PG, UK.
Alun EvansCentre of Excellence for Public Health, Queens University Belfast, Grosvenor Road, Belfast BT126JP, UK.
Tove FallDepartment of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Martin FarrallWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.
Janine F FelixDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, P.O.Box 2040, 3000 CA Rotterdam, The Netherlands.
Jean FerrièresToulouse University School of Medicine, Rangueil University Hospital, INSERM UMR1027, Toulouse, France.
Luigi FerrucciTranslational Gerontology Branch, National Institute on Aging, Baltimore MD, USA.
Myriam FornageInstitute of Molecular Medicine, University of Texas Health Science Center at Houston, TX, USA.
Terrence ForresterTropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona, Kingston 7, Jamaica.
Nora FranceschiniDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA.
Oscar H Franco DuranDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, P.O.Box 2040, 3000 CA Rotterdam, The Netherlands.
Anders Franco-CerecedaDepartment of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, 45110, Greece.
Ross M FraserInstitute for Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland.
Santhi K GaneshUniversity of Michigan Medical School, 7220 MSRB III, Ann Arbor MI 48109, USA.
He GaoDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London W2 1PG, UK.
Karl GertowCardiovascular Research Unit, Center for Molecular Medicine L8:03, Department of Medicine, Karolinska Institutet, 171 76 Stockholm, Sweden.
Francesco GianfagnaEPIMED Research Centre - Epidemiology and Preventive Medicine, Department of Clinical and Experimental Medicine, University of Insubria, Varese, Italy.
Bruna GiganteDivision of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Franco GiulianiniDivision of Preventive Medicine, Brigham and Women's Hospital, 900 Commonwealth Ave. East, Boston, MA 02215, USA.
Anuj GoelWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.
Alison H GoodallDepartment of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester LE3 9QP, UK.
Mark O GoodarziDivision of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Mathias GorskiDepartment of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany.
Jürgen GräßlerDepartment of Medicine III, Division Pathobiochemistry, Technische Universität Dresden, Dresden, Germany.
Christopher GrovesOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.
Vilmundur GudnasonIcelandic Heart Association, Kopavogur, Iceland.
Ulf GyllenstenDepartment of Immunology, Genetics and Pathology, University of Uppsala, Box 815, Biomerical center, 751 08 Uppsala, Sweden.
Göran HallmansDepartment of Public Health and Clinical Medicine, Umeå University, Sweden.
Anna-Liisa HartikainenInstitute of Clinical Medicine/Obstetrics and Gynaecology, University of Oulu, Oulu, Finland.
Maija HassinenKuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Aki S HavulinnaNational Institute for Health and Welfare, FI-00271 Helsinki, Finland.
Caroline HaywardInstitute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, EH4 2XU Scotland, UK.
Serge HercbergUREN, INSERM U557, INRA U1125, CNAM, SMBH, Sorbonne Paris Cité, Université Paris 13, Bobigny, France.
Karl-Heinz HerzigInstitute of Biomedicine, University of Oulu, Medical Research Center Oulu and Oulu University Hospital, Finland.
Andrew A HicksCenter for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, 39100, Italy - affiliated institute of the University of Lübeck, Germany.
Aroon D HingoraniGenetic Epidemiology Group, Dept. Epidemiology and Public Health, UCL, London, WC1E 6BT, UK.
Joel N HirschhornDivision of Endocrinology, Boston Children's Hospital, Boston, MA 02115, USA.
Albert HofmanDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, P.O.Box 2040, 3000 CA Rotterdam, The Netherlands.
Jostein HolmenHUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, 7600 Levanger, Norway.
Oddgeir Lingaas HolmenHUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, 7600 Levanger, Norway.
Jouke-Jan HottengaDepartment of Biological Psychology, VU University, Amsterdam, The Netherlands.
Phil HowardDepartment of Cardiovascular Genetics, Institute of Cardiovascular Sciences, University College London, London WC1E 6JF, UK.
Chao A HsiungDivision of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes. 35 Keyan Rd., Zhunan Town, Miaoli County 350, Taiwan.
Steven C HuntCardiovascular Genetics Division, University of Utah School of Medicine, Salt Lake City, Utah, USA.
M Arfan IkramDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, P.O.Box 2040, 3000 CA Rotterdam, The Netherlands.
Thomas IlligResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, Neuherberg 85764, Germany.
Carlos IribarrenKaiser Permanente, Division of Research, Oakland, CA 94612, USA.
Richard A JensenHuman Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, 1200 Pressler St., Suite 453E, Houston, TX 77030, USA.
Mika KähönenDepartment of Clinical Physiology, Tampere University Hospital, Tampere 33521, Finland.
Hyun KangDepartment of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA.
Sekar KathiresanCenter for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA.
Brendan J KeatingDivision of Transplantation, Department of Surgery, University of Pennsylvania, PA 19104 USA.
Kay-Tee KhawDepartment of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge CB2 2SR, UK.
Yun Kyoung KimCenter for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
Eric KimInstitute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, 1124 W. Carson Street, Torrance, CA 90502, USA.
Mika KivimakiGenetic Epidemiology Group, Dept. Epidemiology and Public Health, UCL, London, WC1E 6BT, UK.
Norman KloppResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, Neuherberg 85764, Germany.
Genovefa Kolovou1st Cardiology Department, Onassis Cardiac Surgery Center 356, Sygrou Ave, Athens, Greece.
Pirjo KomulainenKuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Jaspal S KoonerNational Heart and Lung Institute, Imperial College London, Hammersmith Hospital Campus, Ducane Road, London W12 0NN, UK.
Gulum KosovaCardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA.
Ronald M KraussDepartment of Medicine, Children's Hospital Oakland Research Institute, Oakland, CA 94609, USA.
Diana KuhMRC Unit for Lifelong Health and Ageing at UCL, London, WC1B 5JU, UK.
Zoltan KutalikDepartment of Medical Genetics, University of Lausanne, Lausanne, Switzerland.
Johanna KuusistoDepartment of Medicine, University of Eastern Finland and Kuopio University Hospital, 70210 Kuopio, Finland.
Kirsti KvaløyHUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, 7600 Levanger, Norway.
Timo A LakkaInstitute of Biomedicine/Physiology, University of Eastern Finland, Kuopio Campus, Finland.
Nanette R LeeOffice of Population Studies Foundation Inc., Talamban, Cebu City, 6000, Philippines.
I-Te LeeDivision of Endocrine and Metabolism, Department of Internal Medicine, Chichung Veterans General Hospital, Taichung 40705, Taiwan.
Wen-Jane LeeDepartment of Medical Research, Taichung Veterans General Hospital, Taichung 407, Taiwan.
Daniel LevyNational Heart, Lung and Blood Institute's Framingham Heart Study, Framingham, MA 01702, USA.
Xiaohui LiInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, 1124 W. Carson Street, Torrance, CA 90502, USA.
Kae-Woei LiangCardiovascular Center, Taichung Veterans General Hospital, Taichung, 40705, Taiwan.
Honghuang LinSection of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, 02446 MA, USA.
Li LinCardiology, Department of Medicine, Geneva University Hospital, Rue Gabrielle-Perret-Gentil 4, 1211 Geneva 14, Switzerland.
Jaana LindströmNational Institute for Health and Welfare, FI-00271 Helsinki, Finland.
Stéphane LobbensEuropean Genomic Institute for Diabetes (EGID), FR 3508 Lille, France.
Satu MännistöNational Institute for Health and Welfare, FI-00271 Helsinki, Finland.
Gabriele MüllerCenter for Evidence-based Healthcare, University of Dresden, Medical Faculty Carl Gustav Carus, Fetscherstrasse 74, 01307 Dresden, Germany.
Martina Müller-NurasyidInstitute of Genetic Epidemiology, Helmholtz Zentrum München, Neuherberg 85764, Germany.
François MachCardiology, Department of Medicine, Geneva University Hospital, Rue Gabrielle-Perret-Gentil 4, 1211 Geneva 14, Switzerland.
Hugh S MarkusNeurology Unit, University of Cambridge, R3, Box 83, Cambridge Biomedical Campus, Cambridge, Cb2 0QQ, UK.
Eirini MarouliWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Mark I McCarthyOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.
Colin A McKenzieTropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona, Kingston 7, Jamaica.
Pierre MenetonINSERM U1142 LIMICS, UMR_S 1142 Sorbonne Universités, UPMC Université Paris 06, Université Paris 13, Paris, France.
Cristina MenniDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Andres MetspaluEstonian Genome Center, University of Tartu, Tartu, 51010, Estonia.
Vladan MijatovicDepartment of Life and Reproduction Sciences, University of Verona, Strada le Grazie 8, 37134 Verona, Italy.
Leena MoilanenDepartment of Medicine, Kuopio University Hospital, Kuopio, Finland.
May E MontasserDepartment of Medicine, Program for Personalized and Genomic Medicine, University of Maryland, School of Medicine, Baltimore, Maryland 21201, USA.
Andrew D MorrisMedical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK.
Alanna C MorrisonDepartment of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, 1200 Pressler St., Suite 453E, Houston, TX 77030, USA.
Antonella MulasIstituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monseratto, Monserrato, Cagliari 09042, Italy.
Ramaiah NagarajaLaboratory of Genetics, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA.
Narisu NarisuMedical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA.
Kjell NikusDepartment of Cardiology, School of Medicine, University of Tampere, Tampere 33014, Finland.
Christopher J O'DonnellNational Heart, Lung and Blood Institute, Division of Intramural Research, Bethesda, MD, USA.
Paul F O'ReillyInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, UK.
Ken K OngMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
Fred PaccaudInstitute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Route de la Corniche 10, 1010 Lausanne, Switzerland.
Cameron D PalmerDivisions of Endocrinology, Children's Hospital Boston, Massachusetts 02115, USA.
Afshin ParsaDepartment of Medicine, Program for Personalized and Genomic Medicine, University of Maryland, School of Medicine, Baltimore, Maryland 21201, USA.
Nancy L PedersenDept of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, SE-171 77 Stockholm, Sweden.
Brenda W PenninxDepartment of Psychiatry, EMGO Institute, Neuroscience Campus, VU University Medical Centre, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands.
Markus PerolaNational Institute for Health and Welfare, FI-00271 Helsinki, Finland.
Annette PetersInstitute of Epidemiology II, Helmholtz Zentrum München, Neuherberg 85764, Germany.
Neil PoulterInternational Centre for Circulatory Health, Imperial College London, W2 1PG, UK.
Peter P PramstallerCenter for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, 39100, Italy - affiliated institute of the University of Lübeck, Germany.
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA.
Thomas QuertermousDepartment of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Dabeeru C RaoDivision of Biostatistics, Washington University School of Medicine, Saint Louis, MO, 63110, USA.
Asif RasheedCenter for Non-Communicable Diseases, Karachi, Pakistan.
N William N W R RaynerOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.
Frida RenströmDepartment of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skåne University Hospital Malmö, SE-205 02 Malmö, Sweden.
Rainer RettigInstitute of Physiology, University Medicine Greifswald, Greifswald, Germany.
Kenneth M RiceDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Robert RobertsUniversity of Ottawa Heart Institute, Cardiovascular Research Methods Centre Ontario, Canada.
Lynda M RoseDivision of Preventive Medicine, Brigham and Women's Hospital, 900 Commonwealth Ave. East, Boston, MA 02215, USA.
Jacques RossouwNational Heart, Lung, and Blood Institute, 6701 Rockledge Ave., Bethesda, MD 20892, USA.
Nilesh J SamaniDepartment of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester LE3 9QP, UK.
Serena SannaIstituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monseratto, Monserrato, Cagliari 09042, Italy.
Jouko SaramiesSouth Karelia Central Hospital, Lappeenranta, Finland.
Heribert SchunkertDeutsches Herzzentrum München, Germany.
Sylvain SebertCenter For Life-course Health Research, P.O.Box 5000, FI-90014 University of Oulu, Finland.
Wayne H-H SheuDivision of Endocrine and Metabolism, Department of Internal Medicine, Chichung Veterans General Hospital, Taichung 40705, Taiwan.
Young-Ah ShinCenter for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
Xueling SimDepartment of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA.
Johannes H SmitDepartment of Psychiatry, EMGO Institute, Neuroscience Campus, VU University Medical Centre, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands.
Albert V SmithIcelandic Heart Association, Kopavogur, Iceland.
Maria X SosaCenter for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Tim D SpectorDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Alena StančákováUniversity of Eastern Finland and Kuopio University Hospital, 70210 Kuopio, Finland.
Alice StantonConway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 4, Ireland.
Kathleen E StirrupsWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Heather M StringhamDepartment of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA.
Johan SundstromUppsala University, Department of Medical Sciences, SE-75185 Uppsala, Sweden.
Amy J SwiftMedical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA.
Ann-Christine SyvänenUppsala University, Department of Medical Sciences, SE-75185 Uppsala, Sweden.
E-Shyong TaiDepartment of Medicine, National University of Singapore and National University Health System, Singapore 119228, Singapore.
Toshiko TanakaTranslational Gerontology Branch, National Institute on Aging, Baltimore MD, USA.
Kirill V TarasovLaboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, 21224, USA.
Alexander TeumerInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Unnur ThorsteinsdottirdeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Martin D TobinDepartment of Health Sciences, University of Leicester, University Rd, Leicester LE1 7RH, UK.
Elena TremoliDipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano, Milan, Italy.
Andre G UitterlindenDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, P.O.Box 2040, 3000 CA Rotterdam, The Netherlands.
Matti UusitupaDepartment of Public Health and Clinical Nutrition, University of Eastern Finland, Finland.
Ahmad VaezDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.
Dhananjay VaidyaJohns Hopkins Medical Institutions, 1830 East Monument St., Baltimore, MD 21287, USA.
Cornelia M van DuijnDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, P.O.Box 2040, 3000 CA Rotterdam, The Netherlands.
Erik P A van IperenDepartment of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, Amsterdam, The Netherlands.
Ramachandran S VasanNational Heart, Lung and Blood Institute's Framingham Heart Study, Framingham, MA 01702, USA.
Germaine C VerwoertDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, P.O.Box 2040, 3000 CA Rotterdam, The Netherlands.
Jarmo VirtamoNational Institute for Health and Welfare, FI-00271 Helsinki, Finland.
Veronique VitartInstitute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, EH4 2XU Scotland, UK.
Benjamin F VoightProgram in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA.
Peter VollenweiderDepartment of Internal medicine, University Hospital Lausanne, Lausanne, Switzerland.
Aline WagnerDepartment of Epidemiology and Public Health, EA3430, University of Strasbourg, Strasbourg, France.
Louise V WainDepartment of Health Sciences, University of Leicester, University Rd, Leicester LE1 7RH, UK.
Nicholas J WarehamMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
Hugh WatkinsWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.
Alan B WederDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.
Harm-Jan WestraUniversity Medical Center Groningen, University of Groningen, Groningen, 9700RB, The Netherlands.
Rainford WilksEpidemiology Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona, Kingston 7, Jamaica.
Tom WilsgaardDepartment of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway.
James F WilsonInstitute for Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland.
Tien Y WongSingapore Eye Research Institute, Singapore National Eye Centre, Singapore 168751, Singapore.
Tsun-Po YangWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Jie YaoInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, 1124 W. Carson Street, Torrance, CA 90502, USA.
Loic YengoEuropean Genomic Institute for Diabetes (EGID), FR 3508 Lille, France.
Weihua ZhangDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London W2 1PG, UK.
Jing Hua ZhaoMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
Xiaofeng ZhuDepartment of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University, Cleveland, OH, 44106, USA.
Pascal BovetMinistry of Health, Victoria, Republic of Seychelles.
Richard S CooperDepartment of Preventive Medicine and Epidemiology, Loyola University Chicago Stritch School of Medicine, Maywood, IL, 60153, USA.
Karen L MohlkeDepartment of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.
Danish SaleheenDepartment of Biostatistics and Epidemiology, University of Pennsylvania, USA.
Jong-Young LeeCenter for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
Paul ElliottDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London W2 1PG, UK.
Hinco J GiermanDept. Dev. Bio. And Genetics, Stanford University Medical Center, Stanford, CA 94305, USA.
Cristen J WillerDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.
Lude FrankeDepartment of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, 9711, The Netherlands.
G Kees HovinghDept Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands.
Kent D TaylorInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, 1124 W. Carson Street, Torrance, CA 90502, USA.
George DedoussisDepartment of Dietetics-Nutrition, Harokopio University, 70 El. Venizelou Str, Athens, Greece.
Peter SeverInternational Centre for Circulatory Health, Imperial College London, W2 1PG, UK.
Andrew WongMRC Unit for Lifelong Health and Ageing at UCL, London, WC1B 5JU, UK.
Lars LindUppsala University, Department of Medical Sciences, SE-75185 Uppsala, Sweden.
Themistocles L AssimesDepartment of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Inger NjølstadDepartment of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway.
Peter Eh SchwarzDept of Medicine III, University of Dresden, Medical Faculty Carl Gustav Carus, Fetscherstrasse 74, 01307 Dresden, Germany.
Claudia LangenbergMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
Harold SniederDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.
Mark J CaulfieldClinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, EC1M 6BQ, UK.
Olle MelanderUniversity of Lund, Dept Internal Medicine, Malmo, SE 20502, Sweden.
Markku LaaksoDepartment of Medicine, University of Eastern Finland and Kuopio University Hospital, 70210 Kuopio, Finland.
Juha SaltevoDepartment of Medicine, Central Finland Health Care District, Jyväskylä, Finland.
Rainer RauramaaKuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Jaakko TuomilehtoNational Institute for Health and Welfare, FI-00271 Helsinki, Finland.
Erik IngelssonDepartment of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland.
Kristian HveemHUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, 7600 Levanger, Norway.
Walter PalmasDepartment of Medicine, Columbia University, 622 West 168th St., New York, NY 10032, USA.
Winfried MärzSynlab Academy, Synlab Services GmbH, P5, 7, 68161 Mannheim, Germany.
Meena KumariGenetic Epidemiology Group, Dept. Epidemiology and Public Health, UCL, London, WC1E 6BT, UK.
Veikko SalomaaNational Institute for Health and Welfare, FI-00271 Helsinki, Finland.
Yii-Der I ChenInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, 1124 W. Carson Street, Torrance, CA 90502, USA.
Jerome I RotterInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, 1124 W. Carson Street, Torrance, CA 90502, USA.
Philippe FroguelEuropean Genomic Institute for Diabetes (EGID), FR 3508 Lille, France.
Marjo-Riitta JarvelinCenter For Life-course Health Research, P.O.Box 5000, FI-90014 University of Oulu, Finland.
Edward G LakattaLaboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, 21224, USA.
Kari KuulasmaaNational Institute for Health and Welfare, FI-00271 Helsinki, Finland.
Paul W FranksDepartment of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skåne University Hospital Malmö, SE-205 02 Malmö, Sweden.
Anders HamstenCardiovascular Research Unit, Center for Molecular Medicine L8:03, Department of Medicine, Karolinska Institutet, 171 76 Stockholm, Sweden.
H-Erich WichmannInstitute of Epidemiology I, Helmholtz Zentrum München, Neuherberg 85764, Germany.
Colin N A PalmerMedical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK.
Kari StefanssondeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Paul M RidkerDivision of Preventive Medicine, Brigham and Women's Hospital, 900 Commonwealth Ave. East, Boston, MA 02215, USA.
Ruth J F LoosMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
Aravinda ChakravartiCenter for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Panos DeloukasWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Andrew P MorrisDepartment of Biostatistics, University of Liverpool, Liverpool L69 3GA, UK.
Christopher Newton-ChehCenter for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA.
Patricia B MunroeClinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, EC1M 6BQ, UK.
Queen Mary University of London · GBUniversity of Cambridge · GBUppsala University · SEBroad Institute · USFinnish Institute for Health and Welfare · FIUniversity of Eastern Finland · FIUniversity of Michigan · USCentre for Human Genetics · GBUCLA Medical Center · USErasmus MC · NLJohns Hopkins University · USKarolinska Institutet · SEHelmholtz Zentrum München · DENational Heart Lung and Blood Institute · USNational Human Genome Research Institute · USBrigham and Women's Hospital · USdeCODE Genetics (Iceland) · ISInserm · FRInstitute on Aging · USKorea National Institute of Health · KR

Funding

VCID and Stroke in a Bi-racial National CohortU01NS041588 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CUSHMAN, MARY, HOWARD, GEORGE · 2002 to 2022
$96.0M
THE FRAMINGHAM HEART STUDYN01HC25195 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI RAMACHANDRAN, VASAN S · 2007 to 2014
$83.8M
Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8M
ZONA-FREE HAMSTER OVA ASSAY AS AN INDICATOR OF MALE FERTILITYM01RR000425 · NCRR · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI ANDERSON, GAIL V · 1985 to 2011
$74.2M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024156 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2006 to 2011
$53.0M
Framingham Project/LevyZIAHL006001 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEVY, DANIEL · 2009 to 2025
$51.1M
VANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7M
XENOBIOTIC BIOTRANSFORMATION AND DISPOSITIONP30ES007033 · NIEHS · UNIVERSITY OF WASHINGTON · PI Sheela Sathyanarayana · 1995 to 2026
$42.5M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4M
ZINC AND CA EDTA THERAPY OF PLUMBISMM01RR000052 · NCRR · JOHNS HOPKINS UNIVERSITY · PI MARSH, LAURA · 1985 to 2007
$37.3M
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3M
Arthritis Research UKBritish Heart Foundation FS/13/6/29977British Heart Foundation PG/02/128British Heart Foundation RG/07/005/23633British Heart Foundation RG08/008British Heart Foundation RG/10/12/28456British Heart Foundation RG/13/13/30194British Heart Foundation RG/13/2/30098British Heart Foundation RG/14/5/30893British Heart Foundation RG2008/014British Heart Foundation SP/04/002British Heart Foundation SP/08/005/25115British Heart Foundation SP/10/6/28562Chief Scientist OfficeFIC NIH HHS R01 TW005596FIC NIH HHS R01 TW008288FIC NIH HHS RC1 TW008485Medical Research Council 85374Medical Research Council G0000934Medical Research Council G0401527Medical Research Council G0500539Medical Research Council G0600237Medical Research Council G0600705Medical Research Council G0601261Medical Research Council G0601966Medical Research Council G0700931Medical Research Council G1000143Medical Research Council G1002319Medical Research Council G9521010DMedical Research Council MC_PC_U127561128Medical Research Council MC_UU_12013/5Medical Research Council MC_UU_12015/1Medical Research Council MC_UU_12019/1Medical Research Council MR/K006584/1Medical Research Council MR/K013351/1Medical Research Council MR/L003120/1Medical Research Council MR/L01341X/1Medical Research Council MR/N003284/1Medical Research Council MR/N015746/1NCATS NIH HHS UL1 TR000124NCI NIH HHS UM1 CA182913NCRR NIH HHS M01 RR000052NCRR NIH HHS M01 RR000425NCRR NIH HHS M01 RR010284NCRR NIH HHS M01 RR016500NCRR NIH HHS P20 RR020649NCRR NIH HHS U54 RR020278NCRR NIH HHS UL1 RR024156NCRR NIH HHS UL1 RR024975NCRR NIH HHS UL1 RR025005NCRR NIH HHS UL1 RR025774NCRR NIH HHS UL1 RR033176NEI NIH HHS R01 EY014684NEI NIH HHS R01 EY018246NEI NIH HHS ZIA EY000401NHGRI NIH HHS HHSN268200782096CNHGRI NIH HHS N01HG65403NHGRI NIH HHS U01 HG004402NHGRI NIH HHS U01 HG007416NHGRI NIH HHS Z01 HG000024NHGRI NIH HHS Z01 HG200362NHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100012CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS K23 HL080025NHLBI NIH HHS K24 HL004334NHLBI NIH HHS K99 HL094535NHLBI NIH HHS N01 HC005187NHLBI NIH HHS N01 HC015103NHLBI NIH HHS N01 HC035129NHLBI NIH HHS N01 HC045133NHLBI NIH HHS N01 HC045134NHLBI NIH HHS N01 HC045204NHLBI NIH HHS N01 HC045205NHLBI NIH HHS N01 HC048047NHLBI NIH HHS N01 HC048048NHLBI NIH HHS N01 HC048049NHLBI NIH HHS N01 HC048050NHLBI NIH HHS N01 HC055015NHLBI NIH HHS N01 HC055018NHLBI NIH HHS N01 HC055019NHLBI NIH HHS N01 HC085084NHLBI NIH HHS N01 HC085085NHLBI NIH HHS N01 HC095095NHLBI NIH HHS N01HC25195NHLBI NIH HHS N01HC55016NHLBI NIH HHS N01HC55020NHLBI NIH HHS N01HC55021NHLBI NIH HHS N01HC55222NHLBI NIH HHS N01HC65226NHLBI NIH HHS N01HC75150NHLBI NIH HHS N01HC85079NHLBI NIH HHS N01HC85080NHLBI NIH HHS N01HC85081NHLBI NIH HHS N01HC85082NHLBI NIH HHS N01HC85083NHLBI NIH HHS N01HC85086NHLBI NIH HHS N01HC95159NHLBI NIH HHS N01HC95160NHLBI NIH HHS N01HC95161NHLBI NIH HHS N01HC95162NHLBI NIH HHS N01HC95163NHLBI NIH HHS N01HC95164NHLBI NIH HHS N01HC95165NHLBI NIH HHS N01HC95166NHLBI NIH HHS N01HC95167NHLBI NIH HHS N01HC95168NHLBI NIH HHS N01HC95169NHLBI NIH HHS N01WH32102NHLBI NIH HHS N01 WH42114NHLBI NIH HHS N02HL64278NHLBI NIH HHS R01 HL036310NHLBI NIH HHS R01 HL043851NHLBI NIH HHS R01 HL046380NHLBI NIH HHS R01 HL053353NHLBI NIH HHS R01 HL055673NHLBI NIH HHS R01 HL059367NHLBI NIH HHS R01 HL059684NHLBI NIH HHS R01 HL071025NHLBI NIH HHS R01 HL074166NHLBI NIH HHS R01 HL075366NHLBI NIH HHS R01 HL077477NHLBI NIH HHS R01 HL080295NHLBI NIH HHS R01 HL080467NHLBI NIH HHS R01 HL085144NHLBI NIH HHS R01 HL085251NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01 HL087641NHLBI NIH HHS R01 HL087647NHLBI NIH HHS R01 HL087652NHLBI NIH HHS R01 HL087660NHLBI NIH HHS R01 HL087679NHLBI NIH HHS R01 HL087698NHLBI NIH HHS R01 HL088119NHLBI NIH HHS R01 HL093029NHLBI NIH HHS R01 HL093328NHLBI NIH HHS R01 HL098283NHLBI NIH HHS R01 HL103612NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL109512NHLBI NIH HHS R01 HL109946NHLBI NIH HHS R01 HL113933NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01 HL122684NHLBI NIH HHS R21 HL123677NHLBI NIH HHS RC1 HL100245NHLBI NIH HHS RC2 HL101834NHLBI NIH HHS T32 HL007208NHLBI NIH HHS T32 HL007902NHLBI NIH HHS T32 HL098049NHLBI NIH HHS U01 HL054471NHLBI NIH HHS U01 HL054472NHLBI NIH HHS U01 HL054473NHLBI NIH HHS U01 HL054495NHLBI NIH HHS U01 HL054496NHLBI NIH HHS U01 HL054497NHLBI NIH HHS U01 HL054509NHLBI NIH HHS U01 HL069757NHLBI NIH HHS U01 HL072515NHLBI NIH HHS U01 HL072518NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL084756NHLBI NIH HHS U01 HL096917NIA NIH HHS HHSN271201200022CNIA NIH HHS N01 AG012100NIA NIH HHS N01 AG062101NIA NIH HHS N01 AG062103NIA NIH HHS N01 AG062106NIA NIH HHS N01AG12109NIA NIH HHS R01 AG010175NIA NIH HHS R01 AG013196NIA NIH HHS R01 AG015928NIA NIH HHS R01 AG016592NIA NIH HHS R01 AG018728NIA NIH HHS R01 AG020098NIA NIH HHS R01 AG023629NIA NIH HHS R01 AG025941NIA NIH HHS R01 AG027058NIA NIH HHS R01 AG028555NIA NIH HHS R01 AG032098NIA NIH HHS T32 AG000219NIA NIH HHS Z01 AG000513NIA NIH HHS ZIA AG007380NICHD NIH HHS P2C HD050924NICHD NIH HHS R03 HD061437NICHD NIH HHS R03 HD062783NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK056350NIDDK NIH HHS P30 DK063491NIDDK NIH HHS P30 DK072488NIDDK NIH HHS P60 DK079637NIDDK NIH HHS R01 DK054261NIDDK NIH HHS R01 DK062370NIDDK NIH HHS R01 DK072193NIDDK NIH HHS R01 DK078150NIDDK NIH HHS R01 DK079888NIDDK NIH HHS R01 DK084350NIDDK NIH HHS R01 DK093757NIDDK NIH HHS R01 DK101478NIDDK NIH HHS U01 DK062370NIEHS NIH HHS P30 ES007033NIEHS NIH HHS P30 ES010126NIGMS NIH HHS S06 GM008016NIGMS NIH HHS U01 GM074518NIH HHS N01 WH42124NIMH NIH HHS R01 MH063706NIMH NIH HHS RC2 MH089951NIMH NIH HHS RL1 MH083268NINDS NIH HHS R21 NS064908NINDS NIH HHS U01 NS041588Wellcome Trust 068545/Z/02Wellcome Trust 081917/Z/07/ZWellcome Trust 084723/Z/08/ZWellcome Trust 085475/B/08/ZWellcome Trust 090532/Z/09/ZWellcome Trust 098051Wellcome Trust WT098017WHI NIH HHS N01 WH032105WHI NIH HHS N01 WH032118WHI NIH HHS N01 WH032119WHI NIH HHS N01 WH032122WHI NIH HHS N01 WH042107WHI NIH HHS N01 WH042109WHI NIH HHS N01 WH042110WHI NIH HHS N01 WH042111WHI NIH HHS N01 WH042112WHI NIH HHS N01 WH042115WHI NIH HHS N01 WH042116WHI NIH HHS N01 WH042117WHI NIH HHS N01 WH042118WHI NIH HHS N01 WH042119WHI NIH HHS N01 WH042120WHI NIH HHS N01 WH042121WHI NIH HHS N01 WH042122WHI NIH HHS N01 WH042123WHI NIH HHS N01 WH042125WHI NIH HHS N01 WH042126WHI NIH HHS N01 WH042129WHI NIH HHS N01 WH042130WHI NIH HHS N01 WH042131WHI NIH HHS N01 WH042132WHI NIH HHS N01 WH044221WHI NIH HHS N01WH22110WHI NIH HHS N01WH24152WHI NIH HHS N01WH32100WHI NIH HHS N01WH32101WHI NIH HHS N01WH32106WHI NIH HHS N01WH32108WHI NIH HHS N01WH32109WHI NIH HHS N01WH32111WHI NIH HHS N01WH32112WHI NIH HHS N01WH32113WHI NIH HHS N01WH32115WHI NIH HHS N01WH42108WHI NIH HHS N01WH42113
6 · The paper itself

Abstract

To dissect the genetic architecture of blood pressure and assess effects on target organ damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 individuals of European ancestry, and genotypes from an additional 140,886 individuals were used for validation. We identified 66 blood pressure-associated loci, of which 17 were new; 15 harbored multiple distinct association signals. The 66 index SNPs were enriched for cis-regulatory elements, particularly in vascular endothelial cells, consistent with a primary role in blood pressure control through modulation of vascular tone across multiple tissues. The 66 index SNPs combined in a risk score showed comparable effects in 64,421 individuals of non-European descent. The 66-SNP blood pressure risk score was significantly associated with target organ damage in multiple tissues but with minor effects in the kidney. Our findings expand current knowledge of blood pressure-related pathways and highlight tissues beyond the classical renal system in blood pressure regulation.

Indexed as

Asian PeopleBlack PeopleBlood PressureCells, CulturedGenome-Wide Association StudyHumansHypertensionMicroarray AnalysisPolymorphism, Single Nucleotide

Identifiers

PMID27618452
PMCPMC5042863
OpenAlexW2519445944

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