Evidence map›Paper›PMID 27618448›Full record

SynthesisNature genetics2016

Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci.

Chunyu Liu, Aldi T Kraja, Jennifer A Smith, Jennifer A Brody, Nora Franceschini, Joshua C Bis, Kenneth Rice, Alanna C Morrison, Yingchang Lu, Stefan Weiss and 91 more

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 169 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
169citing papers in PubMed, 16 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

169 citing papers in PubMed, 16 syntheses or guidelines pooled it.

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  10. Guideline
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  16. Journal of the American Society of Nephrology : JASN · 2017
    Pooled it
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  18. Biologics for cardiovascular diseases: from bench to bedside.Signal transduction and targeted therapy · 2026
    Review
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109 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

101 authors.

Chunyu LiuFramingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, Massachusetts, USA.
Aldi T KrajaDivision of Statistical Genomics, Department of Genetics and Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri, USA.
Jennifer A SmithDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-3575-5468
Jennifer A BrodyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.
Nora FranceschiniGillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Joshua C BisCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.
Kenneth RiceDepartment of Biostatistics, University of Washington, Seattle, Washington, USA.
Alanna C MorrisonHuman Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston Texas, USA.
Yingchang LuCharles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Stefan WeissDZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
Xiuqing GuoInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, California, USA.
Walter PalmasDivision of General Medicine, Columbia University Medical Center, New York, New York, USA.
Lisa W MartinGeorge Washington University School of Medicine and Health Sciences, Washington, DC, USA.
Yii-Der Ida ChenInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, California, USA.
Praveen SurendranCardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Fotios DrenosCentre for Cardiovascular Genetics, Institute of Cardiovascular Science, University College London, London, UK.
James P CookDepartment of Biostatistics, University of Liverpool, Liverpool, UK.
Paul L AuerJoseph J. Zilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, USA.
Audrey Y ChuFramingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, Massachusetts, USA.
Ayush GiriVanderbilt Epidemiology Center, Vanderbilt Genetics Institute, Institute for Medicine and Public Health, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Wei ZhaoDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
Johanna JakobsdottirIcelandic Heart Association, Kopavogur, Iceland.
Li-An LinInstitute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas, USA.ORCID 0000-0003-2731-1346
Jeanette M StaffordDivision of Public Health Sciences, Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Najaf AminGenetic Epidemiology Unit, Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.
Hao MeiDepartment of Data Science, School of Population Health, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Jie YaoInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, California, USA.
Arend VoormanBill and Melinda Gates Foundation, Seattle, Washington, USA.
CHD Exome+ Consortium
ExomeBP Consortium
GoT2DGenes Consortium
T2D-GENES Consortium
Martin G LarsonFramingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, Massachusetts, USA.
Megan L GroveHuman Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston Texas, USA.
Albert V SmithIcelandic Heart Association, Kopavogur, Iceland.ORCID 0000-0003-1942-5845
Shih-Jen HwangFramingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, Massachusetts, USA.
Han ChenDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.ORCID 0000-0002-9510-4923
Tianxiao HuanFramingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, Massachusetts, USA.
Gulum KosovaCenter for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA.
Nathan O StitzielDivision of Cardiology, Department of Medicine and Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA.
Sekar KathiresanCenter for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA.
Nilesh SamaniDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Heribert SchunkertDeutsches Herzzentrum München, Technische Universität München, Munich, Germany.
Panos DeloukasPrincess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, Saudi Arabia.ORCID 0000-0001-9251-070X
Myocardial Infarction Genetics and CARDIoGRAM Exome Consortia
Man LiDepartment of Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA.ORCID 0000-0002-3839-0281
Christian FuchsbergerCenter for Biomedicine, European Academy of Bozen/Bolzano (EURAC), Bolzano, Italy (affiliated with the University of Lübeck, Lübeck, Germany).
Cristian PattaroCenter for Biomedicine, European Academy of Bozen/Bolzano (EURAC), Bolzano, Italy (affiliated with the University of Lübeck, Lübeck, Germany).
Mathias GorskiDepartment of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany.
CKDGen Consortium
Charles KooperbergDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
George J PapanicolaouDivision of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA.
Jacques E RossouwDivision of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA.
Jessica D FaulSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan, USA.
Sharon L R KardiaDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
Claude BouchardPennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, USA.
Leslie J RaffelMedical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
André G UitterlindenDepartment of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.
Oscar H FrancoDepartment of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.
Ramachandran S VasanFramingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, Massachusetts, USA.
Christopher J O'DonnellFramingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, Massachusetts, USA.
Kent D TaylorInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, California, USA.
Kiang LiuNorthwestern University School of Medicine, Chicago, Illinois, USA.
Erwin P BottingerCharles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Omri GottesmanCharles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
E Warwick DawDivision of Statistical Genomics, Department of Genetics and Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri, USA.
Franco GiulianiniDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Santhi GaneshDepartment of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA.
Elias SalfatiCenter for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Tamara B HarrisLaboratory of Epidemiology, Demography and Biometry, National Institute on Aging, US National Institutes of Health, Bethesda, Maryland, USA.
Lenore J LaunerNeuroepidemiology Section, National Institute on Aging, US National Institutes of Health, Bethesda, Maryland, USA.
Marcus DörrDZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
Stephan B FelixDZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
Rainer RettigDZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
Henry VölzkeDZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
Eric KimInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, California, USA.
Wen-Jane LeeDepartment of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.
I-Te LeeDivision of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Wayne H-H SheuDivision of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Krystal S TsosieVanderbilt Epidemiology Center, Vanderbilt Genetics Institute, Institute for Medicine and Public Health, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Digna R Velez EdwardsVanderbilt Epidemiology Center, Vanderbilt Genetics Institute, Institute for Medicine and Public Health, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Yongmei LiuEpidemiology and Prevention Center for Genomics and Personalized Medicine Research, Wake Forest Baptist Medical Center, Winston-Salem, North Carolina, USA.
Adolfo CorreaDepartment of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA.ORCID 0000-0002-9501-600X
David R WeirSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan, USA.
Uwe VölkerDZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
Paul M RidkerDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Eric BoerwinkleHuman Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston Texas, USA.
Vilmundur GudnasonIcelandic Heart Association, Kopavogur, Iceland.
Alexander P ReinerDepartment of Epidemiology, University of Washington, Seattle, Washington, USA.
Cornelia M van DuijnGenetic Epidemiology Unit, Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.
Ingrid B BoreckiDivision of Statistical Genomics, Department of Genetics and Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri, USA.
Todd L EdwardsVanderbilt Epidemiology Center, Vanderbilt Genetics Institute, Institute for Medicine and Public Health, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0003-4318-6119
Aravinda ChakravartiCenter for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Jerome I RotterInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, California, USA.
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.
Ruth J F LoosCharles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Myriam FornageInstitute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas, USA.
Georg B EhretCenter for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-5730-0675
Christopher Newton-ChehCenter for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA.
Daniel LevyFramingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, Massachusetts, USA.
Daniel I ChasmanDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.

Funding

HRS Yrs29-34: Y33 SSA CoFundingU01AG009740 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jessica Faul, KENNETH M LANGA · 1990 to 2026
$555.8M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024156 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2006 to 2011
$53.0M
The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4M
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3M
Women's Health Study: Continued Follow-upR01CA047988 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., LEE, I-MIN · 1991 to 2014
$28.2M
Building on GWAS for NHLBI-disease: the CHARGE consortiumRC2HL102419 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BOERWINKLE, ERIC A. · 2009 to 2010
$27.6M
MULTIDISCIPLINARY RESEARCH TRAINING IN CARDIOLOGYT32HL007208 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Patrick Thomas Ellinor, David E Sosnovik · 1985 to 2026
$16.1M
Multi-Ethnic Study of Atherosclerosis (MESA) StudyR01HL071205 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI ROTTER, JEROME I · 2003 to 2007
$10.4M
Vanderbilt/Meharry Initiative for Minority Student DvptR25GM062459 · NIGMS · VANDERBILT UNIVERSITY · PI VELEZ EDWARDS, DIGNA R · 2002 to 2020
$10.4M
Exceptional Survival: Trajectories to Functional Aging (CHS All Stars)R01AG023629 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEWMAN, ANNE B. · 2004 to 2016
$9.5M
British Heart Foundation RG/14/5/30893Medical Research Council G0800270Medical Research Council MC_UU_12013/5NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1 TR000445NCI NIH HHS R01 CA047988NCI NIH HHS UM1 CA182913NCRR NIH HHS UL1 RR024156NHGRI NIH HHS U01 HG004603NHGRI NIH HHS U01 HG004729NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268200900041CNHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100012CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HHSN268201300025CNHLBI NIH HHS HHSN268201300026CNHLBI NIH HHS HHSN268201300027CNHLBI NIH HHS HHSN268201300028CNHLBI NIH HHS HHSN268201300029CNHLBI NIH HHS HHSN268201300046CNHLBI NIH HHS HHSN268201300047CNHLBI NIH HHS HHSN268201300048CNHLBI NIH HHS HHSN268201300049CNHLBI NIH HHS HHSN268201300050CNHLBI NIH HHS N01 HC025195NHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01HC95160NHLBI NIH HHS N01HC95161NHLBI NIH HHS N01HC95162NHLBI NIH HHS N01HC95163NHLBI NIH HHS N01HC95164NHLBI NIH HHS N01HC95165NHLBI NIH HHS N01HC95166NHLBI NIH HHS N01HC95167NHLBI NIH HHS N01HC95168NHLBI NIH HHS N01HC95169NHLBI NIH HHS N02HL64278NHLBI NIH HHS R01 HL043851NHLBI NIH HHS R01 HL068986NHLBI NIH HHS R01 HL071205NHLBI NIH HHS R01 HL080295NHLBI NIH HHS R01 HL080467NHLBI NIH HHS R01 HL084099NHLBI NIH HHS R01 HL087652NHLBI NIH HHS R01 HL093029NHLBI NIH HHS R01 HL103612NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL117078NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R21 HL121429NHLBI NIH HHS RC2 HL102419NHLBI NIH HHS T32 HL007208NHLBI NIH HHS U01 HL130114NIA NIH HHS HHSN271201100004CNIA NIH HHS HHSN271201200022CNIA NIH HHS N01 AG012100NIA NIH HHS N01 AG062101NIA NIH HHS N01 AG062103NIA NIH HHS N01 AG062106NIA NIH HHS R01 AG023629NIA NIH HHS R01 AG032098NIA NIH HHS R03 AG046389NIA NIH HHS RC2 AG036495NIA NIH HHS RC4 AG039029NIA NIH HHS U01 AG009740NIDDK NIH HHS K24 DK080140NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK078616NIDDK NIH HHS R01 DK089256NIEHS NIH HHS P30 ES010126NIGMS NIH HHS R25 GM062459NIGMS NIH HHS RC2 GM092618NIH HHS S10 OD018522NIH HHS S10 OD020069WHI NIH HHS HHSN268201100001CWHI NIH HHS HHSN268201100002CWHI NIH HHS HHSN268201100003CWHI NIH HHS HHSN268201100004C
6 · The paper itself

Abstract

Meta-analyses of association results for blood pressure using exome-centric single-variant and gene-based tests identified 31 new loci in a discovery stage among 146,562 individuals, with follow-up and meta-analysis in 180,726 additional individuals (total n = 327,288). These blood pressure-associated loci are enriched for known variants for cardiometabolic traits. Associations were also observed for the aggregation of rare and low-frequency missense variants in three genes, NPR1, DBH, and PTPMT1. In addition, blood pressure associations at 39 previously reported loci were confirmed. The identified variants implicate biological pathways related to cardiometabolic traits, vascular function, and development. Several new variants are inferred to have roles in transcription or as hubs in protein-protein interaction networks. Genetic risk scores constructed from the identified variants were strongly associated with coronary disease and myocardial infarction. This large collection of blood pressure-associated loci suggests new therapeutic strategies for hypertension, emphasizing a link with cardiometabolic risk.

Indexed as

Genetic VariationBlood PressureExomeGenome, HumanGenome-Wide Association StudyGenotypeHumansHypertensionOligonucleotide Array Sequence AnalysisPolymorphism, Single Nucleotide

Identifiers

PMID27618448
PMCPMC5320952

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.