Evidence map›Paper›PMID 27618447›Full record

SynthesisNature genetics2016

Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension.

Praveen Surendran, Fotios Drenos, Robin Young, Helen Warren, James P Cook, Alisa K Manning, Niels Grarup, Xueling Sim, Daniel R Barnes, Kate Witkowska and 214 more

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 198 papers, 19 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
198citing papers in PubMed, 19 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

198 citing papers in PubMed, 19 syntheses or guidelines pooled it.

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  12. Guideline
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138 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

224 authors.

Praveen Surendran *Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Fotios Drenos *Medical Research Council Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol, UK.
Robin Young *Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Helen Warren *Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, UK.
James P Cook *Department of Health Sciences, University of Leicester, Leicester, UK.
Alisa K Manning *Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.
Niels Grarup *The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Xueling Sim *Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.
Daniel R BarnesCardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Kate WitkowskaClinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, UK.
James R StaleyCardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Vinicius TraganteDepartment of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands.
Taru TukiainenDepartment of Genetics, Harvard Medical School, Boston, Massachusetts, USA.
Hanieh YaghootkarGenetics of Complex Traits, Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK.
Nicholas MascaDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Daniel F FreitagCardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Teresa FerreiraWellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Olga GiannakopoulouHeart Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Andrew TinkerHeart Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Magdalena HarakalovaDepartment of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands.
Evelin MihailovEstonian Genome Center, University of Tartu, Tartu, Estonia.
Chunyu LiuNational Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, Massachusetts, USA.
Aldi T KrajaDivision of Statistical Genomics, Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri, USA.
Sune Fallgaard NielsenDepartment of Clinical Biochemistry Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark.
Asif RasheedCentre for Non-Communicable Diseases, Karachi, Pakistan.
Maria SamuelCentre for Non-Communicable Diseases, Karachi, Pakistan.
Wei ZhaoDepartment of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Lori L BonnycastleMedical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, USA.
Anne U JacksonDepartment of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA.
Narisu NarisuMedical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, USA.
Amy J SwiftMedical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, USA.
Lorraine SouthamWellcome Trust Sanger Institute, Genome Campus, Hinxton, UK.
Jonathan MartenMedical Research Council Human Genetics Unit, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Jeroen R HuygheDepartment of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA.
Alena StančákováDepartment of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
Cristiano FavaUniversity of Lund, Department of Clinical Sciences, Malmö, Sweden.
Therese OhlssonUniversity of Lund, Department of Clinical Sciences, Malmö, Sweden.
Angela MatchanWellcome Trust Sanger Institute, Genome Campus, Hinxton, UK.
Kathleen E StirrupsHeart Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Jette Bork-JensenThe Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Anette P GjesingThe Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Jukka KonttoDepartment of Health, National Institute for Health and Welfare, Helsinki, Finland.
Markus PerolaDepartment of Health, National Institute for Health and Welfare, Helsinki, Finland.
Susan Shaw-HawkinsClinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, UK.
Aki S HavulinnaDepartment of Health, National Institute for Health and Welfare, Helsinki, Finland.
He ZhangDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Louise A DonnellyMedical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.
Christopher J GrovesOxford Centre for Diabetes, Endocrinology, and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
N William RaynerOxford Centre for Diabetes, Endocrinology, and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Matt J NevilleOxford Centre for Diabetes, Endocrinology, and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Neil R RobertsonWellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Andrianos M YiorkasSection of Investigative Medicine, Imperial College London, London, UK.
Karl-Heinz HerzigInstitute of Biomedicine, Biocenter Oulu, University of Oulu, Oulu, Finland.
Eero KajantieDepartment of Health, National Institute for Health and Welfare, Helsinki, Finland.
Weihua ZhangDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Sara M WillemsMedical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.
Lars LannfeltDepartment of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden.
Giovanni MalerbaSection of Biology and Genetics, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Nicole SoranzoHuman Genetics, Wellcome Trust Sanger Institute, Hinxton, UK.
Elisabetta TrabettiSection of Biology and Genetics, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Niek VerweijUniversity Medical Center Groningen, University of Groningen, Department of Cardiology, The Netherlands.
Evangelos EvangelouDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Alireza MoayyeriDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Anne-Claire VergnaudDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Christopher P NelsonDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Alaitz PovedaDepartment of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, Sweden.
Tibor V VargaDepartment of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, Sweden.
Muriel CaslakeUniversity of Glasgow, Glasgow, UK.
Anton Jm de CraenDepartment of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.
Stella TrompetDepartment of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.
Jian'an LuanMedical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.
Robert A ScottMedical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.
Sarah E HarrisCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
David Cm LiewaldCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Riccardo MarioniCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Cristina MenniDepartment of Twin Research and Genetic Epidemiology, King's College London, UK.
Aliki-Eleni FarmakiDepartment of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece.
Göran HallmansDepartment of Biobank Research, Umeå University, Umeå, Sweden.
Frida RenströmDepartment of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, Sweden.
Jennifer E HuffmanMedical Research Council Human Genetics Unit, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Maija HassinenKuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Stephen BurgessCardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Ramachandran S VasanNational Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, Massachusetts, USA.
Janine F FelixDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
CHARGE-Heart Failure Consortium
Maria Uria-NickelsenDevelopment Management and Planning, Pfizer Worldwide Research and Development.
Anders MalarstigPfizer Worldwide Research and Development, Stockholm, Sweden.
Dermot F ReilyMerck Research Laboratories, Genetics and Pharmacogenomics, Boston, Massachusetts, USA.
Maarten HoekMerck Research Laboratories, Cardiometabolic Disease, Kenilworth, New Jersey, USA.
Thomas VogtMerck Research Laboratories, Cardiometabolic Disease, Kenilworth, New Jersey, USA.
Honghuang LinNational Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, Massachusetts, USA.
Wolfgang LiebInstitute of Epidemiology and Biobank Popgen, Kiel University, Kiel, Germany.
EchoGen Consortium
Matthew TraylorNeurology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.
Hugh F MarkusNeurology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.
METASTROKE Consortium
Heather M HighlandUniversity of North Carolina at Chapel Hill, Department of Epidemiology, Chapel Hill, North Carolina, USA.
Anne E JusticeUniversity of North Carolina at Chapel Hill, Department of Epidemiology, Chapel Hill, North Carolina, USA.
Eirini MarouliHeart Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
GIANT Consortium
Jaana LindströmDepartment of Health, National Institute for Health and Welfare, Helsinki, Finland.
Matti UusitupaDepartment of Public Health and Clinical Nutrition, University of Eastern Finland, Finland.
Pirjo KomulainenKuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Timo A LakkaKuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Rainer RauramaaKuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Ozren PolasekCentre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Igor RudanCentre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Olov RolandssonDepartment of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
Paul W FranksDepartment of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, Sweden.
George DedoussisDepartment of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece.
Timothy D SpectorDepartment of Twin Research and Genetic Epidemiology, King's College London, UK.
EPIC-InterAct Consortium
Pekka JousilahtiDepartment of Health, National Institute for Health and Welfare, Helsinki, Finland.
Satu MännistöDepartment of Health, National Institute for Health and Welfare, Helsinki, Finland.
Ian J DearyCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
John M StarrCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Claudia LangenbergMedical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.
Nick J WarehamMedical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.
Morris J BrownClinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, UK.
Anna F DominiczakInstitute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
John M ConnellMedical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.
J Wouter JukemaDepartment of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
Naveed SattarInstitute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
Ian FordUniversity of Glasgow, Glasgow, UK.
Chris J PackardUniversity of Glasgow, Glasgow, UK.
Tõnu EskoEstonian Genome Center, University of Tartu, Tartu, Estonia.
Reedik MägiEstonian Genome Center, University of Tartu, Tartu, Estonia.
Andres MetspaluEstonian Genome Center, University of Tartu, Tartu, Estonia.
Rudolf A de BoerDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Peter van der MeerDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Pim van der HarstDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Lifelines Cohort Study
Giovanni GambaroDivision of Nephrology, Department of Internal Medicine and Medical Specialties, Columbus - Gemelli University Hospital, Catholic University, Rome, Italy.
Erik IngelssonDepartment of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Lars LindDepartment of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Paul Iw de BakkerDepartment of Medical Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.
Mattijs E NumansDepartment of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands.
Ivan BrandslundDepartment of Clinical Biochemistry, Lillebaelt Hospital, Vejle, Denmark.
Cramer ChristensenMedical Department, Lillebaelt Hospital, Vejle, Denmark.
Eva Rb PetersenDepartment of Clinical Immunology and Biochemistry, Lillebaelt Hospital, Vejle, Denmark.
Eeva Korpi-HyövältiSouth Ostrobothnia Central Hospital, Seinäjoki, Finland.
Heikki OksaTampere University Hospital, Tampere, Finland.
John C ChambersDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Jaspal S KoonerDepartment of Cardiology, Ealing Hospital, Middlesex, UK.
Alexandra If BlakemoreSection of Investigative Medicine, Imperial College London, London, UK.
Steve FranksInstitute of Reproductive and Developmental Biology, Imperial College London, London, UK.
Marjo-Riitta JarvelinDepartment of Epidemiology and Biostatistics, Medical Research Council Public Health England Centre for Environment and Health, School of Public Health, Faculty of Medicine, Imperial College London, St. Mary's Campus, London, UK.
Lise L HusemoenResearch Centre for Prevention and Health, Capital Region of Denmark, Copenhagen, Denmark.
Allan LinnebergResearch Centre for Prevention and Health, Capital Region of Denmark, Copenhagen, Denmark.
Tea SkaabyResearch Centre for Prevention and Health, Capital Region of Denmark, Copenhagen, Denmark.
Betina ThuesenResearch Centre for Prevention and Health, Capital Region of Denmark, Copenhagen, Denmark.
Fredrik KarpeOxford Centre for Diabetes, Endocrinology, and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Jaakko TuomilehtoDepartment of Health, National Institute for Health and Welfare, Helsinki, Finland.
Alex Sf DoneyMedical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.
Andrew D MorrisSchool of Molecular, Genetic and Population Health Sciences, University of Edinburgh, Medical School, Teviot Place, Edinburgh, UK.
Colin Na PalmerMedical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.
Oddgeir Lingaas HolmenHUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway.
Kristian HveemHUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway.
Cristen J WillerDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Tiinamaija TuomiFolkhälsan Research Centre, Helsinki, Finland; Department of Endocrinology, Helsinki University Central Hospital, Helsinki, Finland.
Leif GroopDepartment of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden.
AnneMari KäräjämäkiDepartment of Primary Health Care, Vaasa Central Hospital, Vaasa, Finland.
Aarno PalotieAnalytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Samuli RipattiInstitute for Molecular Medicine Finland University of Helsinki, Helsinki, Finland.
Veikko SalomaaDepartment of Health, National Institute for Health and Welfare, Helsinki, Finland.
Dewan S AlamICDDR, B; Mohakhali, Dhaka, Bangladesh.
Abdulla Al Shafi MajumderNational Institute of Cardiovascular Diseases, Sher-e-Bangla Nagar, Dhaka, Bangladesh.
Emanuele Di AngelantonioCardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Rajiv ChowdhuryCardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Mark I McCarthyOxford Centre for Diabetes, Endocrinology, and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Neil PoulterInternational Centre for Circulatory Health, Imperial College London, UK.
Alice V StantonMolecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland.
Peter SeverInternational Centre for Circulatory Health, Imperial College London, UK.
Philippe AmouyelUniversity of Lille, UMR1167, Risk Factors and Molecular Determinants of aging-related diseases, Lille, France.
Dominique ArveilerDepartment of Epidemiology and Public Health, EA 3430, University of Strasbourg, Strasbourg, France.
Stefan BlankenbergDepartment of General and Interventional Cardiology, University Heart Center Hamburg, Germany.
Jean FerrièresDepartment of Epidemiology, UMR 1027- INSERM, Toulouse University-CHU Toulouse, Toulouse, France.
Frank KeeDirector, UKCRC Centre of Excellence for Public Health, Queens University, Belfast, Northern Ireland.
Kari KuulasmaaDepartment of Health, National Institute for Health and Welfare, Helsinki, Finland.
Martina Müller-NurasyidInstitute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
Giovanni VeronesiResearch Center in Epidemiology and Preventive Medicine, Department of Clinical and Experimental Medicine, University of Insubria, Varese, Italy.
Jarmo VirtamoDepartment of Health, National Institute for Health and Welfare, Helsinki, Finland.
Panos DeloukasHeart Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Wellcome Trust Case Control Consortium
Paul ElliottDepartment of Epidemiology and Biostatistics, Medical Research Council Public Health England Centre for Environment and Health, School of Public Health, Faculty of Medicine, Imperial College London, St. Mary's Campus, London, UK.
Understanding Society Scientific Group
Eleftheria ZegginiWellcome Trust Sanger Institute, Genome Campus, Hinxton, UK.
Sekar KathiresanCenter for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA.
Olle MelanderUniversity of Lund, Department of Clinical Sciences, Malmö, Sweden.
Johanna KuusistoDepartment of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
Markku LaaksoDepartment of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
Sandosh PadmanabhanInstitute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
David PorteousCentre for Genomic and Experimental Medicine, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Caroline HaywardMedical Research Council Human Genetics Unit, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Generation ScotlandA Collaboration between the University Medical Schools and NHS, Aberdeen, Dundee, Edinburgh and Glasgow, UK.
Francis S CollinsMedical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, USA.
Karen L MohlkeDepartment of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA.
Torben HansenThe Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Oluf PedersenThe Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Michael BoehnkeDepartment of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA.
Heather M StringhamDepartment of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA.
EPIC-CVD Consortium
Philippe FrossardCentre for Non-Communicable Diseases, Karachi, Pakistan.
Christopher Newton-ChehCenter for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA.
CHARGE+ Exome Chip Blood Pressure Consortium
Martin D TobinDepartment of Health Sciences, University of Leicester, Leicester, UK.
Børge Grønne NordestgaardDepartment of Clinical Biochemistry Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark.
T2D-GENES Consortium
GoT2DGenes Consortium
ExomeBP Consortium
CHD Exome+ Consortium
Mark J CaulfieldClinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, UK.
Anubha MahajanWellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Andrew P MorrisWellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Maciej TomaszewskiDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Nilesh J SamaniDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Danish Saleheen *Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Folkert W Asselbergs *Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands.
Cecilia M Lindgren *The Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK.
John Danesh *Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Louise V Wain *Department of Health Sciences, University of Leicester, Leicester, UK.
Adam S Butterworth *Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Joanna Mm Howson *Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Patricia B Munroe *Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, UK.

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
Pilot and Feasibility ProgramP30DK020595 · NIDDK · UNIVERSITY OF CHICAGO · PI Raghavendra G Mirmira · 2013 to 2026
$20.9M
Low-Pass Sequencing and High-Density SNP Genotyping for Type 2 DiabetesRC2DK088389 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALTSHULER, DAVID, BOEHNKE, MICHAEL L · 2009 to 2010
$17.9M
Multiethnic Study of Type 2 Diabetes GenesU01DK085526 · NIDDK · BROAD INSTITUTE, INC. · PI ALTSHULER, DAVID, JABLONSKI, KATHLEEN ANN · 2009 to 2014
$15.7M
Identifying Genes for Type 2 Diabetes: FUSIONU01DK062370 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOEHNKE, MICHAEL L, SCOTT, LAURA J. · 2009 to 2021
$11.6M
Targeted Genetic Analysis of T2D and Quantitative TraitsR01DK072193 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN L. MOHLKE · 2005 to 2026
$11.3M
Cardiovascular Epidemiology Training GrantT32HL007055 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Wayne D. Rosamond · 1986 to 2026
$10.0M
Using genetics to discover mechanisms of myocardial infarctionR01HL109946 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI YUQING Eugene CHEN, Ida Liisa Surakka · 2011 to 2026
$8.9M
Genetic epidemiology of rare and regulatory variants for metabolic traitsR01DK093757 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN L. MOHLKE · 2011 to 2026
$8.2M
Using genetic variation to study biology of blood lipids & coronary heart diseaseR01HL127564 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Pradeep Natarajan, Gina Marie Peloso · 2015 to 2026
$7.3M
GENETIC ANALYSIS OF TYPE II DIABETES IN FINNISH POPULATIONZ01HG000024 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI COLLINS, FRANCIS S. · 1995 to 2008
$6.2M
Gene-Environment Interactions and Weight GainR01HD057194 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GORDON-LARSEN, PENNY, NORTH, KARI E. · 2008 to 2019
$5.9M
Biotechnology and Biological Sciences Research CouncilBritish Heart Foundation FS/14/66/31293British Heart Foundation PG/02/128British Heart Foundation RG/07/005/23633British Heart Foundation RG/14/5/30893British Heart Foundation RG/15/15/31742British Heart Foundation SP/04/002British Heart Foundation SP/08/005/25115British Heart Foundation SP/09/002British Heart Foundation SP/10/6/28562Chief Scientist Office CZD/16/6/4Medical Research Council G0000934Medical Research Council G0500539Medical Research Council G0600237Medical Research Council G0600705Medical Research Council G0601966Medical Research Council G0700931Medical Research Council G0800270Medical Research Council G0802782Medical Research Council G0902313Medical Research Council G1002319Medical Research Council G9521010DMedical Research Council MC_PC_U127561128Medical Research Council MC_U106179471Medical Research Council MC_UU_00002/7Medical Research Council MC_UU_12013/5Medical Research Council MC_UU_12015/1Medical Research Council MR/K006584/1Medical Research Council MR/K026992/1Medical Research Council MR/L01341X/1NCI NIH HHS HHSN261200800001ENHGRI NIH HHS Z01 HG000024NHLBI NIH HHS HHSN268201000029CNHLBI NIH HHS K99 HL094535NHLBI NIH HHS R01 HL087679NHLBI NIH HHS R01 HL107816NHLBI NIH HHS R01 HL109946NHLBI NIH HHS R01 HL127564NHLBI NIH HHS T32 HL007055NICHD NIH HHS R01 HD057194NIDA NIH HHS R01 DA006227NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK020595NIDDK NIH HHS R01 DK072193NIDDK NIH HHS R01 DK093757NIDDK NIH HHS RC2 DK088389NIDDK NIH HHS U01 DK062370NIDDK NIH HHS U01 DK085501NIDDK NIH HHS U01 DK085524NIDDK NIH HHS U01 DK085526NIDDK NIH HHS U01 DK085545NIDDK NIH HHS U01 DK085584NIMH NIH HHS R01 MH063706NIMH NIH HHS R01 MH101810NIMH NIH HHS R01 MH101822NIMH NIH HHS RL1 MH083268NLM NIH HHS R01 LM010098Wellcome Trust 068545/Z/02Wellcome Trust 083948Wellcome Trust 084723/Z/08/ZWellcome Trust 085475Wellcome Trust 086596/Z/08/ZWellcome Trust 098051Wellcome Trust 100114Wellcome Trust WT091310Wellcome Trust WT098017Wellcome Trust WT098381
6 · The paper itself

Abstract

High blood pressure is a major risk factor for cardiovascular disease and premature death. However, there is limited knowledge on specific causal genes and pathways. To better understand the genetics of blood pressure, we genotyped 242,296 rare, low-frequency and common genetic variants in up to 192,763 individuals and used ∼155,063 samples for independent replication. We identified 30 new blood pressure- or hypertension-associated genetic regions in the general population, including 3 rare missense variants in RBM47, COL21A1 and RRAS with larger effects (>1.5 mm Hg/allele) than common variants. Multiple rare nonsense and missense variant associations were found in A2ML1, and a low-frequency nonsense variant in ENPEP was identified. Our data extend the spectrum of allelic variation underlying blood pressure traits and hypertension, provide new insights into the pathophysiology of hypertension and indicate new targets for clinical intervention.

Indexed as

Genetic VariationBlood PressureGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansHypertension

Identifiers

PMID27618447
PMCPMC5056636

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.