ArticlePLoS genetics2016
Oligomerization of SCFTIR1 Is Essential for Aux/IAA Degradation and Auxin Signaling in Arabidopsis.
Article in PLoS genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 46 citations in OpenAlex.
- Genetically Encoded, Noise-Tolerant, Auxin Biosensors in Yeast.ACS synthetic biology · 2024Article
- Study on Design, Synthesis and Herbicidal Activity of Novel 6-Indazolyl-2-picolinic Acids.Molecules (Basel, Switzerland) · 2024Article
- Identification of potential auxin response candidate genes for soybean rapid canopy coverage through comparative evolution and expression analysis.Frontiers in plant science · 2024Article
- Omics analyses of Rehmannia glutinosa dedifferentiated and cambial meristematic cells reveal mechanisms of catalpol and indole alkaloid biosynthesis.BMC plant biology · 2023Article
- Arabidopsis Tubby domain-containing F-box proteins positively regulate immunity by modulating PI4Kβ protein levels.The New phytologist · 2023Article
- Adenosine monophosphate deaminase modulates BIN2 activity through hydrogen peroxide-induced oligomerization.The Plant cell · 2022Article
- The Systems and Synthetic Biology of Auxin.Cold Spring Harbor perspectives in biology · 2022Review
- TIR1/AFB proteins: Active players in abiotic and biotic stress signaling.Frontiers in plant science · 2022Review
- TheInternational journal of molecular sciences · 2021Article
- No Time for Transcription-Rapid Auxin Responses in Plants.Cold Spring Harbor perspectives in biology · 2021Review
- S-Nitrosation of E3 Ubiquitin Ligase Complex Components Regulates Hormonal Signalings in Arabidopsis.Frontiers in plant science · 2021Article
- SUSA2 is an F-box protein required for autoimmunity mediated by paired NLRs SOC3-CHS1 and SOC3-TN2.Nature communications · 2020Article
- Regulation of auxin transcriptional responses.Developmental dynamics : an official publication of the American Association of Anatomists · 2020Review
- Article
- Non-canonical AUX/IAA protein IAA33 competes with canonical AUX/IAA repressor IAA5 to negatively regulate auxin signaling.The EMBO journal · 2020Article
- Accelerating structure-function mapping using the ViVa webtool to mine natural variation.Plant direct · 2019Article
- Gnp4/LAX2, a RAWUL protein, interferes with the OsIAA3-OsARF25 interaction to regulate grain length via the auxin signaling pathway in rice.Journal of experimental botany · 2018Article
- E3 Ubiquitin Ligases: Key Regulators of Hormone Signaling in Plants.Molecular & cellular proteomics : MCP · 2018Review
- Aux/IAA Gene Family in Plants: Molecular Structure, Regulation, and Function.International journal of molecular sciences · 2018Review
- Auxin signaling: a big question to be addressed by small molecules.Journal of experimental botany · 2018Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
The phytohormone auxin is a key regulator of plant growth and development. Molecular studies in Arabidopsis have shown that auxin perception and signaling is mediated via TIR1/AFB-Aux/IAA co-receptors that assemble as part of the SCFTIR1/AFB E3 ubiquitin-ligase complex and direct the auxin-regulated degradation of Aux/IAA transcriptional repressors. Despite the importance of auxin signaling, little is known about the functional regulation of the TIR1/AFB receptor family. Here we show that TIR1 can oligomerize in planta via a set of spatially clustered amino acid residues. While none of the residues identified reside in the interaction interface of the TIR1-Aux/IAA degron, they nonetheless regulate the binding of TIR1 to Aux/IAA substrate proteins and their subsequent degradation in vivo as an essential aspect of auxin signaling. We propose oligomerization of TIR1 as a novel regulatory mechanism in the regulation of auxin-mediated plant patterning and development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.