ArticleCell stem cell2016
Adventitial MSC-like Cells Are Progenitors of Vascular Smooth Muscle Cells and Drive Vascular Calcification in Chronic Kidney Disease.
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Article in Cell stem cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 190 papers.
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190citing papers in PubMed
23.0field-weighted citation impact, top 1% of its field
What it found
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Who cites it
190 citing papers in PubMed, 297 citations in OpenAlex.
- High cut-off dialysis mitigates pro-calcific effects of plasma on vascular progenitor cells.Scientific reports · 2021Trial
- Targeting Gli1Stem cell reviews and reports · 2026Review
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- Atherosclerotic Cell Fates: A Single-Cell View of ER Stress.Journal of cardiovascular development and disease · 2026Review
- A rare pre-existing progenitor-like Primed SMC compartment is the dominant inferred source of SMC-derived cellularity in vascular injury and atherosclerosis.bioRxiv : the preprint server for biology · 2026Article
- Elastin calcification during the initial stage of vascular calcification in kl/kl mice is suppressed by the calcimimetic upacicalcet.Scientific reports · 2026Article
- Proliferation-dependent adipogenic differentiation of progenitor cells in rat coronary artery explants.Stem cell research & therapy · 2026Article
- Fibroblast-like cells accumulate late in human coronary atherosclerosis contributing to necrotic core formation.Cardiovascular research · 2026Article
- Type 2 lymphocytes restrict type 3 lymphocytes during liver fibrosis and colocalize in fibroblast niches.Science advances · 2026Article
- Contribution of Gli1Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Endothelial-to-Mesenchymal Transition in Post-Myocardial Infarction Fibrosis: A Maladaptive but Targetable Pathway.EJIFCC · 2026Review
- Vascular adventitial cells and vascular remodeling: when a harp of thousand strings does not keep in tune so long.Frontiers in physiology · 2026Review
- Asparagine endopeptidase prompts breast cancer-related pericardial calcification by regulating IGF2 and integrin αvβ5.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Hedgehog signaling pathway is an influential factor on vascular biology: a review.Journal of physiology and biochemistry · 2025Review
- Modelling Atherosclerotic Plaque Cap Mechanics: Microcalcifications Reduce Mechanical Properties in Mesenchymal Stromal Cell-Based Model.Advanced biology · 2025Article
- Pharmacological targeting of the IL-17/neutrophil axis attenuates calcific deposits in rat models of calciphylaxis.The Journal of clinical investigation · 2025Article
- Diabetes-Specific Serum Calcium Thresholds for Mortality Risk: A NHANES Nutritional Epidemiology Study.Food science & nutrition · 2025Article
- Adventitial Fibroblasts Release Interleukin 6 After Vascular Injury and Induce Smooth Muscle Cell Proliferation and Neointima Formation.Journal of the American Heart Association · 2025Article
- Mechanisms and therapeutic potential of the hedgehog signaling pathway in cancer.Cell death discovery · 2025Review
- Renal aging and its consequences: navigating the challenges of an aging population.Frontiers in pharmacology · 2025Review
130 more citing papers are in PubMed but not listed here.
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Authors and funding
15 authors at 3 institutions in 2 countries.
Rafael KramannDivision of Nephrology and Clinical Immunology, Medical Faculty RWTH Aachen University, RWTH Aachen University, 52074 Aachen, Germany; Renal Division, Brigham and Women's Hospital and Department of Medicine, Harvard Medical School, Boston, MA 02138, USA. Electronic address: rkramann@gmx.net.
Claudia GoettschCenter for Interdisciplinary Cardiovascular Sciences, Cardiovascular Division, Brigham and Women's Hospital, Boston, MA 02115, USA.
Janewit WongboonsinDivision of Nephrology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Hiroshi IwataCenter for Interdisciplinary Cardiovascular Sciences, Cardiovascular Division, Brigham and Women's Hospital, Boston, MA 02115, USA.
Rebekka K SchneiderDivision of Hematology, Brigham and Women's Hospital and Department of Medicine, Harvard Medical School, Boston, MA 02138, USA; Division of Hematology, RWTH Aachen University, 52074 Aachen, Germany.
Christoph KuppeDivision of Nephrology and Clinical Immunology, Medical Faculty RWTH Aachen University, RWTH Aachen University, 52074 Aachen, Germany.
Nadine KaeslerDivision of Nephrology and Clinical Immunology, Medical Faculty RWTH Aachen University, RWTH Aachen University, 52074 Aachen, Germany.
Monica Chang-PanessoDivision of Nephrology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Flavia G MachadoDivision of Nephrology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Susannah GratwohlDepartment of Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.
Kaushal MadhurimaDivision of Nephrology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Joshua D HutchesonCenter for Interdisciplinary Cardiovascular Sciences, Cardiovascular Division, Brigham and Women's Hospital, Boston, MA 02115, USA.
Sanjay JainDivision of Nephrology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Elena AikawaCenter for Interdisciplinary Cardiovascular Sciences, Cardiovascular Division, Brigham and Women's Hospital, Boston, MA 02115, USA; Center for Excellence in Vascular Biology, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02138, USA.
Benjamin D HumphreysDivision of Nephrology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Washington University in St. Louis · USBrigham and Women's Hospital · USRWTH Aachen University · DE
Funding
Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0MWashington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4MUnderstanding Myofibroblast Progenitor Fate and Function in Renal FibrosisR01DK103740 · NIDDK · WASHINGTON UNIVERSITY · PI BENJAMIN D. HUMPHREYS · 2015 to 2026
$3.9MHedgehog Signaling in Kidney Homeostasis and RepairR01DK088923 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI HUMPHREYS, BENJAMIN D. · 2010 to 2014
$2.0MRetinoic Acid in Myofibrolast Activation and Kidney FibrosisR01DK103050 · NIDDK · WASHINGTON UNIVERSITY · PI HUMPHREYS, BENJAMIN D. · 2014 to 2016
$701kAdult Progenitors in Kidney TubulointerstitiumUH2DK107374 · NIDDK · WASHINGTON UNIVERSITY · PI HUMPHREYS, BENJAMIN D. · 2015 to 2016
$626kEXPRESSION PROFILES FOR RET-POSITIVE DRG NEURONSU01DK101039 · NIDDK · WASHINGTON UNIVERSITY · PI JAIN, SANJAY · 2013 to 2013
$287kMeis1 and Cell Cycle in Kidney Injury and AgingF32DK103441 · NIDDK · WASHINGTON UNIVERSITY · PI CHANG-PANESSO, MONICA · 2014 to 2015
$126kNCATS NIH HHS UL1 TR000448NCI NIH HHS P30 CA091842NIDDK NIH HHS F32 DK103441NIDDK NIH HHS R01 DK088923NIDDK NIH HHS R01 DK103050NIDDK NIH HHS R01 DK103740NIDDK NIH HHS U01 DK101039NIDDK NIH HHS UH2 DK107374
Abstract
Mesenchymal stem cell (MSC)-like cells reside in the vascular wall, but their role in vascular regeneration and disease is poorly understood. Here, we show that Gli1
Indexed as
AdventitiaAgedAnimalsAntigens, CD34Ataxin-1BiomarkersCell DedifferentiationCell DifferentiationCell LineageCell MovementCell ProliferationFemaleHedgehog ProteinsHumansMaleMesenchymal Stem CellsAntigens, CD34Ataxin-1BiomarkersGLI1 protein, humanGli1 protein, mouseHedgehog ProteinsReceptor, Platelet-Derived Growth Factor betaSHH protein, humanZinc Finger Protein GLI1
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.