ReviewInternational journal of molecular sciences2016
Molecular Imaging of Vulnerable Atherosclerotic Plaques in Animal Models.
Review in International journal of molecular sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 37 citations in OpenAlex.
- Construction and evaluation of a combined model of NAA/STZ-induced type 2 diabetes with carotid balloon injury in SD rats.Frontiers in endocrinology · 2025Article
- Integrated Ultrasound Characterization of the Diet-Induced Obesity (DIO) Model in Young Adult c57bl/6j Mice: Assessment of Cardiovascular, Renal and Hepatic Changes.Journal of imaging · 2024Article
- Mouse Cardiovascular Imaging.Current protocols · 2024Review
- Further analysis of natural antibodies against ischemic stroke.Frontiers in neurology · 2023Article
- Translating atherosclerosis research from bench to bedside: navigating the barriers for effective preclinical drug discovery.Clinical science (London, England : 1979) · 2022Article
- Endometriosis promotes atherosclerosis in a murine model.American journal of obstetrics and gynecology · 2022Article
- Lipid-lowering treatment in a rabbit model of atherosclerosis: a vessel wall magnetic resonance imaging study.Annals of translational medicine · 2022Article
- Mechanically Rotating Intravascular Ultrasound (IVUS) Transducer: A Review.Sensors (Basel, Switzerland) · 2021Review
- Establishment of a Novel Mouse Model for Atherosclerotic Vulnerable Plaque.Frontiers in cardiovascular medicine · 2021Article
- SUR1-E1506K mutation impairs glucose tolerance and promotes vulnerable atherosclerotic plaque phenotype in hypercholesterolemic mice.PloS one · 2021Article
- CCL4 Inhibition in Atherosclerosis: Effects on Plaque Stability, Endothelial Cell Adhesiveness, and Macrophages Activation.International journal of molecular sciences · 2020Article
- Three-Dimensional Imaging Provides Detailed Atherosclerotic Plaque Morphology and Reveals Angiogenesis After Carotid Artery Ligation.Circulation research · 2020Article
- Regulatory Mechanisms of Baicalin in Cardiovascular Diseases: A Review.Frontiers in pharmacology · 2020Review
- Modelling of atherosclerosis in genetically modified animals.American journal of translational research · 2019Review
- Response to comment by Moxon et al.Clinical science (London, England : 1979) · 2018Article
- Experimental atherosclerosis models in small animals (Review).Medicine internationalReview
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Atherosclerosis is characterized by intimal plaques of the arterial vessels that develop slowly and, in some cases, may undergo spontaneous rupture with subsequent heart attack or stroke. Currently, noninvasive diagnostic tools are inadequate to screen atherosclerotic lesions at high risk of acute complications. Therefore, the attention of the scientific community has been focused on the use of molecular imaging for identifying vulnerable plaques. Genetically engineered murine models such as ApoE(-/-) and ApoE(-/-)Fbn1C1039G(+/-) mice have been shown to be useful for testing new probes targeting biomarkers of relevant molecular processes for the characterization of vulnerable plaques, such as vascular endothelial growth factor receptor (VEGFR)-1, VEGFR-2, intercellular adhesion molecule (ICAM)-1, P-selectin, and integrins, and for the potential development of translational tools to identify high-risk patients who could benefit from early therapeutic interventions. This review summarizes the main animal models of vulnerable plaques, with an emphasis on genetically altered mice, and the state-of-the-art preclinical molecular imaging strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.