ArticleMolecules (Basel, Switzerland)2016
Synthesis and Antimicrobial Characterization of Half-Calycanthaceous Alkaloid Derivatives.
Article in Molecules (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 15 citations in OpenAlex.
- Heterocyclic-Based Fungicides: Emerging Strategies for Viable Plant Disease Control.Chemistry & biodiversity · 2026Review
- Synthesis and Structure-Activity Analysis of Novel Potential Antifungal Cyclotryptamine Alkaloid Derivatives.Molecules (Basel, Switzerland) · 2023Article
- Synthesis and Antifungal Activity ofMolecules (Basel, Switzerland) · 2022Article
- Resveratrol and Coumarin: Novel Agricultural Antibacterial Agent against Ralstonia solanacearum In Vitro and In Vivo.Molecules (Basel, Switzerland) · 2016Article
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Authors and funding
6 authors at 3 institutions in 1 country.
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Abstract
A total of 29 novel tetrahydropyrroloindol-based calycanthaceous alkaloid derivatives were synthesized from indole-3-acetonitrile in good yields. The synthesized compounds were evaluated against nine strains of bacteria and a wide range of plant pathogen fungi. Bioassay results revealed that majority of the compounds displayed similar or higher in vitro antimicrobial activities than the positive control. The biological activities also indicated that substituents at R₄ and R₅ significantly affect the activities. Notably, compound c4 was found to be most active among the tested calycanthaceous analogues and might be a novel potential leading compound for further development as an antifungal agent. The results could pave the way for further design and structural modification of calycanthaceous alkaloids as antimicrobial agents.
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