Evidence map›Paper›PMID 27617832›Full record

Trial reportPloS one2016

Dexmedetomidine Injection during Strabismus Surgery Reduces Emergence Agitation without Increasing the Oculocardiac Reflex in Children: A Randomized Controlled Trial.

In-Ae Song, Kwang-Suk Seo, Ah-Young Oh, Ji-Seok Baik, Jin Hee Kim, Jung-Won Hwang, Young-Tae Jeon

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 7 pooled it
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 7 syntheses or guidelines pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Trial
  9. Trial
  10. Exploring the trigeminocardiac reflex: an integrated view from mechanism to clinic.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

In-Ae SongDepartment of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
Kwang-Suk SeoDepartment of Dental Anesthesiology, Seoul National University School of Dentistry, Seoul, Korea.
Ah-Young OhDepartment of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
Ji-Seok BaikDepartment of Anesthesiology and Pain Medicine, Pusan National University Hospital, Busan, Korea.
Jin Hee KimDepartment of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
Jung-Won HwangDepartment of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
Young-Tae JeonDepartment of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
Seoul National University · KRSeoul National University Bundang Hospital · KRPusan National University Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveDexmedetomidine is known to reduce the incidence of emergence agitation, which is a common complication after inhalational anesthesia like sevoflurane or desflurane in children. However, the dose of dexmedetomidine used for this purpose is reported variously and the most effective dose is not known. In this study, we tried to find the most effective dose of dexmedetomidine to reduce the incidence of emergence agitation in children undergoing strabismus surgery without the complications like oculocardiac reflex (OCR) or postoperative vomiting.

methodsWe randomized 103 pediatric patients aged 2-6 years and undergoing elective strabismus surgery into four groups. Anesthesia was induced with sevoflurane and maintained with desflurane. At the start of induction, dexmedetomidine, delivered at 0.25, 0.5, or 1 μg/kg, or saline was infused intravenously in the D0.25, D0.5, D1 groups, respectively. The primary outcome measure was the incidence of emergence agitation and the secondary outcome measure was the incidence of intraoperative OCR, postoperative vomiting, and desaturation events.

resultsThe incidence of emergence agitation was 60, 48, 44, and 21% (P = 0.005) and the incidence of intraoperative OCR was 36, 36, 36, and 37% (P = 0.988) in the control, D0.25, D0.5, and D1 groups, respectively. And, postoperative vomiting rate and desaturation events were low in the all groups.

conclusionDexmedetomidine decreased the incidence of emergence agitation without increasing intraoperative oculocardiac reflex. Dexmedetomidine delivered at 1 μg/kg was more effective at reducing emergence agitation than lower doses in children undergoing strabismus surgery under desflurane anesthesia.

trial registrationClinical Research Information Service KCT0000141.

Indexed as

ChildChild, PreschoolDexmedetomidineDose-Response Relationship, DrugEmergence DeliriumFemaleHumansMaleReflex, OculocardiacStrabismusDexmedetomidine

Identifiers

PMID27617832
PMCPMC5019399
OpenAlexW2520949902

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.