ArticleNature biotechnology2016
Blood pressure regulation by CD4
Open access · greenAbstract read
In one paragraph
Article in Nature biotechnology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed
4.9field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
71 citing papers in PubMed, 112 citations in OpenAlex.
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- TLR7 alters the maternal immune landscape during influenza A infection to increase maternal and fetal morbidity.Science advances · 2026Article
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- Neuro-immune interactions in cancer: mechanisms and therapeutic prospects.Frontiers in immunology · 2026Review
- Integrative Neuroimmune Role of the Parasympathetic Nervous System, Vagus Nerve and Gut Microbiota in Stress Modulation: A Narrative Review.International journal of molecular sciences · 2025Review
- Nociceptor α7nAChR activation blunts neuronal HMGB1 release and attenuates inflammation and nociceptive behavior.Molecular medicine (Cambridge, Mass.) · 2025Article
- Integrating neuroscience and oncology: neuroimmune crosstalk in the initiation and progression of digestive system tumors.Molecular cancer · 2025Review
- Immune system influence on physiology.Science (New York, N.Y.) · 2025Review
- Altered Plasma Butyrylcholinesterase Activity in Streptozotocin-Induced Diabetic Hypertensive Rats Does Not Reflect Impaired Liver Function.Physiological research · 2025Article
- Metabolic and Immune Crosstalk in Cardiovascular Disease.Circulation research · 2025Review
- Neuroimmune interactions: The bridge between inflammatory bowel disease and the gut microbiota.Clinical and translational medicine · 2025Review
- Cholinergic T cells revitalize the tumor immune microenvironment: TIME to ChAT.Nature immunology · 2025Review
- B cells modulate lung antiviral inflammatory responses via the neurotransmitter acetylcholine.Nature immunology · 2025Article
- Cholinesterase inhibitors and reduced risk of hospitalization and mortality in patients with Alzheimer's dementia and heart failure.European heart journal. Cardiovascular pharmacotherapy · 2025Article
- Human iPSC-derived mesenchymal stem cells relieve high blood pressure in spontaneously hypertensive rats via splenic nerve activated choline acetyltransferase-positive cells.Science China. Life sciences · 2025Article
- TBrain, behavior, and immunity · 2025Article
- Choline in immunity: a key regulator of immune cell activation and function.Frontiers in immunology · 2025Review
- The role of T cells in vascular aging, hypertension, and atherosclerosis.American journal of physiology. Heart and circulatory physiology · 2024Review
- Consolidating roles of neuroimmune reflexes: specificity of afferent, central, and efferent signals in homeostatic immune networks.Genes & development · 2024Review
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors at 5 institutions in 3 countries.
Peder S OlofssonCenter for Bioelectronic Medicine, Department of Medicine, Center for Molecular Medicine, Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Benjamin E SteinbergLaboratory of Biomedical Science, The Feinstein Institute for Medical Research, Manhasset, New York, USA.
Roozbeh SobbiDivision of Cardiology, Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada.
Maureen A CoxThe Campbell Family Institute for Breast Cancer Research, University Health Network, Toronto, Ontario, Canada.
Mohamed N AhmedCenter for Heart and Lung Research, The Feinstein Institute for Medical Research, Manhasset, New York, USA.
Michaela OswaldRobert S. Boas Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, New York, USA.
Ferenc SzekeresDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
William M HanesLaboratory of Biomedical Science, The Feinstein Institute for Medical Research, Manhasset, New York, USA.
Andrea IntroiniDepartment of Medicine, Solna, Unit of Infectious Diseases, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-9929-8964
Shu Fang LiuCenter for Heart and Lung Research, The Feinstein Institute for Medical Research, Manhasset, New York, USA.
Nichol E HolodickCenter for Oncology and Cell Biology, The Feinstein Institute for Medical Research, Manhasset, New York, USA.
Thomas L RothsteinCenter for Oncology and Cell Biology, The Feinstein Institute for Medical Research, Manhasset, New York, USA.
Cecilia LövdahlDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Sangeeta S ChavanLaboratory of Biomedical Science, The Feinstein Institute for Medical Research, Manhasset, New York, USA.
Huan YangLaboratory of Biomedical Science, The Feinstein Institute for Medical Research, Manhasset, New York, USA.
Valentin A PavlovLaboratory of Biomedical Science, The Feinstein Institute for Medical Research, Manhasset, New York, USA.
Kristina BrolidenDepartment of Medicine, Solna, Unit of Infectious Diseases, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-2224-7664
Ulf AnderssonDepartment of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
Betty DiamondThe Center for Autoimmune and Musculoskeletal Diseases, The Feinstein Institute for Medical Research, Manhasset, New York, USA.ORCID http://orcid.org/0000-0002-3250-3804
Edmund J MillerCenter for Heart and Lung Research, The Feinstein Institute for Medical Research, Manhasset, New York, USA.ORCID http://orcid.org/0000-0002-2131-0054
Anders ArnerDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Peter K GregersenRobert S. Boas Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, New York, USA.
Peter H BackxDivision of Cardiology, Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada.
Tak W MakThe Campbell Family Institute for Breast Cancer Research, University Health Network, Toronto, Ontario, Canada.
Kevin J TraceyLaboratory of Biomedical Science, The Feinstein Institute for Medical Research, Manhasset, New York, USA.
Feinstein Institute for Medical Research · USUniversity Health Network · CAKarolinska Institutet · SEKarolinska University Hospital · SEUniversity of Skövde · SE
Funding
Targeting cognitive and immune impairment in sepsis survivorsP01AI102852 · NIAID · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI VOLPE, BRUCE THOMAS · 2014 to 2018
$11.5MMolecular Basis of Bioelectronic MedicineR35GM118182 · NIGMS · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI TRACEY, KEVIN J · 2016 to 2025
$7.3MPHORBOL ESTER RESPONSIVE B LYMPHOCYTESR01AI029690 · NIAID · WESTERN MICHIGAN UNIV SCHOOL OF MEDICINE · PI ROTHSTEIN, THOMAS L · 1990 to 2019
$6.9MMACROPHAGE INACTIVATION IN SEPSIS AFTER TRAUMA OR SHOCKR01GM057226 · NIGMS · NORTH SHORE UNIVERSITY HOSPITAL · PI TRACEY, KEVIN J · 1999 to 2015
$5.5MMechanism of action and therapeutic potential of HMGB1 A box in sepsisR01GM098446 · NIGMS · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI YANG, HUAN · 2011 to 2014
$1.2MCentral cholinergic regulation of inflammationR01GM089807 · NIGMS · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI PAVLOV, VALENTIN ATANASSOV · 2011 to 2014
$1.1MNIAID NIH HHS P01 AI102852NIAID NIH HHS R01 AI029690NIGMS NIH HHS R01 GM057226NIGMS NIH HHS R01 GM089807NIGMS NIH HHS R01 GM098446NIGMS NIH HHS R35 GM118182
Abstract
Blood pressure regulation is known to be maintained by a neuro-endocrine circuit, but whether immune cells contribute to blood pressure homeostasis has not been determined. We previously showed that CD4
Indexed as
AnimalsBlood PressureCD4-Positive T-LymphocytesCells, CulturedCholine O-AcetyltransferaseFeedback, PhysiologicalFemaleHemostasisMaleMiceMice, Inbred C57BLCholine O-Acetyltransferase
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.