ArticleAnesthesiology2016
Neural Correlates of Wakefulness, Sleep, and General Anesthesia: An Experimental Study in Rat.
Article in Anesthesiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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47 citing papers in PubMed, 89 citations in OpenAlex.
- Evolution and Reorganization of the Hierarchical Brain-wide Neuronal Network Through Anesthesia.Neuroscience bulletin · 2026Article
- Shared Spectral Parameters Between EEG and Basal Ganglia LFP Distinguish Sleep-Specific Oscillations in Parkinson's Disease.European journal of neurology · 2026Article
- Current and Developing Approaches for Facilitating Emergence from General Anesthesia.Anesthesiology · 2025Review
- High-precision neural information detection of multiple brain regions in mice under different concentrations of isoflurane anesthesia based on microelectrode arrays.Microsystems & nanoengineering · 2025Article
- Dysregulated Cholinergic Signaling Inhibits Oligodendrocyte Maturation Following Demyelination.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Prelimbic cortical pyramidal neurons to ventral tegmental area projections promotes arousal from sevoflurane anesthesia.CNS neuroscience & therapeutics · 2024Article
- Evaluation of putative signatures of consciousness using specific definitions of responsiveness, connectedness, and consciousness.British journal of anaesthesia · 2024Article
- Exploring effects of anesthesia on complexity, differentiation, and integrated information in rat EEG.Neuroscience of consciousness · 2024Article
- Brain state identification and neuromodulation to promote recovery of consciousness.Brain communications · 2024Review
- Propofol modulates neural dynamics of thalamo-cortical system associated with anesthetic levels in rats.Cognitive neurodynamics · 2023Article
- Article
- Dose-related adaptive reconstruction of DMN in isoflurane administration: a study in the rat.BMC anesthesiology · 2023Article
- Paradoxical markers of conscious levels: Effects of propofol on patients in disorders of consciousness.Frontiers in human neuroscience · 2022Article
- Brain areas modulation in consciousness during sevoflurane anesthesia.Frontiers in integrative neuroscience · 2022Review
- Glutamatergic Neurons in the Preoptic Hypothalamus Promote Wakefulness, Destabilize NREM Sleep, Suppress REM Sleep, and Regulate Cortical Dynamics.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Consciousness, Anesthesia, and Acetylcholine.Anesthesiology · 2021Article
- Inactivation of Prefrontal Cortex Delays Emergence From Sevoflurane Anesthesia.Frontiers in systems neuroscience · 2021Article
- Automatic Sensory Predictions: A Review of Predictive Mechanisms in the Brain and Their Link to Conscious Processing.Frontiers in human neuroscience · 2021Review
- Power and Coherence in the EEG of the Rat: Impact of Behavioral States, Cortical Area, Lateralization and Light/Dark Phases.Clocks & sleep · 2020Article
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4 authors at 1 institution in 2 countries.
Funding
Abstract
backgroundSignificant advances have been made in our understanding of subcortical processes related to anesthetic- and sleep-induced unconsciousness, but the associated changes in cortical connectivity and cortical neurochemistry have yet to be fully clarified.
methodsMale Sprague-Dawley rats were instrumented for simultaneous measurement of cortical acetylcholine and electroencephalographic indices of corticocortical connectivity-coherence and symbolic transfer entropy-before, during, and after general anesthesia (propofol, n = 11; sevoflurane, n = 13). In another group of rats (n = 7), these electroencephalographic indices were analyzed during wakefulness, slow wave sleep (SWS), and rapid eye movement (REM) sleep.
resultsCompared to wakefulness, anesthetic-induced unconsciousness was characterized by a significant decrease in cortical acetylcholine that recovered to preanesthesia levels during recovery wakefulness. Corticocortical coherence and frontal-parietal symbolic transfer entropy in high γ band (85 to 155 Hz) were decreased during anesthetic-induced unconsciousness and returned to preanesthesia levels during recovery wakefulness. Sleep-wake states showed a state-dependent change in coherence and transfer entropy in high γ bandwidth, which correlated with behavioral arousal: high during wakefulness, low during SWS, and lowest during REM sleep. By contrast, frontal-parietal θ connectivity during sleep-wake states was not correlated with behavioral arousal but showed an association with well-established changes in cortical acetylcholine: high during wakefulness and REM sleep and low during SWS.
conclusionsCorticocortical coherence and frontal-parietal connectivity in high γ bandwidth correlates with behavioral arousal and is not mediated by cholinergic mechanisms, while θ connectivity correlates with cortical acetylcholine levels.
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