ArticleNeuropsychology2016
Engagement with the auditory processing system during targeted auditory cognitive training mediates changes in cognitive outcomes in individuals with schizophrenia.
Article in Neuropsychology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 2 of them syntheses that pooled it.
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The trial behind it
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Who cites it
42 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Relationships Between Auditory Processing and Cognitive Abilities in Adults: A Systematic Review.Journal of speech, language, and hearing research : JSLHR · 2024Pooled it
- Pooled it
- Pharmacologic Augmentation of Computerized Auditory Training in Chronic Psychosis: Preliminary Findings From a Single-Site, Double-Blind Study.Schizophrenia bulletin · 2025Trial
- Central auditory processing deficits in schizophrenia: Effects of auditory-based cognitive training.Schizophrenia research · 2021Trial
- A randomized clinical trial of plasticity-based cognitive training in mild traumatic brain injury.Brain : a journal of neurology · 2021Trial
- Memantine effects on auditory discrimination and training in schizophrenia patients.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Trial
- Gamma oscillations predict pro-cognitive and clinical response to auditory-based cognitive training in schizophrenia.Translational psychiatry · 2020Trial
- Auditory versus visual neuroscience-informed cognitive training in schizophrenia: Effects on cognition, symptoms and quality of life.Schizophrenia research · 2020Trial
- Oscillatory biomarkers of early auditory information processing predict cognitive gains following targeted cognitive training in schizophrenia patients.Schizophrenia research · 2020Trial
- Efference copy/corollary discharge function and targeted cognitive training in patients with schizophrenia.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2019Trial
- Impact of baseline early auditory processing on response to cognitive remediation for schizophrenia.Schizophrenia research · 2019Trial
- Evaluation of a plasticity-based cognitive training program in schizophrenia: Results from the eCaesar trial.Schizophrenia research · 2019Trial
- Verbal learning deficits associated with increased anticholinergic burden are attenuated with targeted cognitive training in treatment refractory schizophrenia patients.Schizophrenia research · 2019Trial
- Neurophysiologic measures of target engagement predict response to auditory-based cognitive training in treatment refractory schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Trial
- A randomized controlled trial comparing a "bottom-up" and "top-down" approach to cognitive training in schizophrenia.Journal of psychiatric research · 2019Trial
- Improving emotion recognition in schizophrenia with "VOICES": An on-line prosodic self-training.PloS one · 2019Trial
- Targeted cognitive training improves auditory and verbal outcomes among treatment refractory schizophrenia patients mandated to residential care.Schizophrenia research · 2018Trial
- Response to Targeted Cognitive Training Correlates with Change in Thalamic Volume in a Randomized Trial for Early Schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Trial
- Feasibility and Acceptability of Remotely Accessed Compensatory Cognitive Training for Japanese People With Schizophrenia: Pilot Study.JMIR formative research · 2025Article
- Personalized Cognitive Health in Psychiatry: Current State and the Promise of Computational Methods.Schizophrenia bulletin · 2024Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundIndividuals with schizophrenia who engage in targeted cognitive training (TCT) of the auditory system show generalized cognitive improvements. The high degree of variability in cognitive gains maybe due to individual differences in the level of engagement of the underlying neural system target.
method131 individuals with schizophrenia underwent 40 hours of TCT. We identified target engagement of auditory system processing efficiency by modeling subject-specific trajectories of auditory processing speed (APS) over time. Lowess analysis, mixed models repeated measures analysis, and latent growth curve modeling were used to examine whether APS trajectories were moderated by age and illness duration, and mediated improvements in cognitive outcome measures.
resultsWe observed significant improvements in APS from baseline to 20 hours of training (initial change), followed by a flat APS trajectory (plateau) at subsequent time-points. Participants showed interindividual variability in the steepness of the initial APS change and in the APS plateau achieved and sustained between 20 and 40 hours. We found that participants who achieved the fastest APS plateau, showed the greatest transfer effects to untrained cognitive domains.
conclusionsThere is a significant association between an individual's ability to generate and sustain auditory processing efficiency and their degree of cognitive improvement after TCT, independent of baseline neurocognition. APS plateau may therefore represent a behavioral measure of target engagement mediating treatment response. Future studies should examine the optimal plateau of auditory processing efficiency required to induce significant cognitive improvements, in the context of interindividual differences in neural plasticity and sensory system efficiency that characterize schizophrenia. (PsycINFO Database Record
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