ArticleAging2016
Higher expression of somatic repair genes in long-lived ant queens than workers.
Article in Aging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 36 citations in OpenAlex.
- Evolution of increased longevity and slowed ageing in a genus of tropical butterfly.Nature communications · 2026Article
- Genome-wide and gene-specific DNA methylation across developmental stages in Pogonomyrmex californicus: A socially polymorphic ant.Insect molecular biology · 2026Article
- Transcriptomic Signatures of Ageing Vary in Solitary and Social Forms of an Orchid Bee.Genome biology and evolution · 2021Article
- Gene Coexpression Network Reveals Highly Conserved, Well-Regulated Anti-Ageing Mechanisms in Old Ant Queens.Genome biology and evolution · 2021Article
- Queen loss increases worker survival in leaf-cutting ants under paraquat-induced oxidative stress.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- Molecular regulation of lifespan extension in fertile ant workers.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- The plasticity of lifespan in social insects.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Experimental increase in fecundity causes upregulation of fecundity and body maintenance genes in the fat body of ant queens.Biology letters · 2021Article
- Eusociality and Senescence: Neuroprotection and Physiological Resilience to Aging in Insect and Mammalian Systems.Frontiers in cell and developmental biology · 2021Review
- Comparative analyses of caste, sex, and developmental stage-specific transcriptomes in twoEcology and evolution · 2020Article
- Long-lived Temnothorax ant queens switch from investment in immunity to antioxidant production with age.Scientific reports · 2019Article
- High expression of the breast cancer susceptibility gene BRCA1 in long-lived termite kings.Aging · 2018Article
- Longevity and transposon defense, the case of termite reproductives.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- New explanation for the longevity of social insect reproductives: Transposable element activity.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
Abstract
Understanding why organisms senesce is a fundamental question in biology. One common explanation is that senescence results from an increase in macromolecular damage with age. The tremendous variation in lifespan between genetically identical queen and worker ants, ranging over an order of magnitude, provides a unique system to study how investment into processes of somatic maintenance and macromolecular repair influence lifespan. Here we use RNAseq to compare patterns of expression of genes involved in DNA and protein repair of age-matched queens and workers. There was no difference between queens and workers in 1-day-old individuals, but the level of expression of these genes increased with age and this up-regulation was greater in queens than in workers, resulting in significantly queen-biased expression in 2-month-old individuals in both legs and brains. Overall, these differences are consistent with the hypothesis that higher longevity is associated with increased investment into somatic repair.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.