ArticlePloS one2016
Odorant Responses and Courtship Behaviors Influenced by at4 Neurons in Drosophila.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Neuroecology of alcohol risk and reward: Methanol boosts pheromones and courtship success inScience advances · 2025Article
- Targeted deletion of olfactory receptors inJournal of neurogenetics · 2024Article
- Article
- Aggregation pheromones have a non-linear effect on oviposition behavior in Drosophila melanogaster.Nature communications · 2023Article
- Transcuticular calcium imaging as a tool for the functional study of insect odorant receptors.Frontiers in molecular neuroscience · 2023Article
- Review
- Valence opponency in peripheral olfactory processing.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Mating increases Drosophila melanogaster females' choosiness by reducing olfactory sensitivity to a male pheromone.Nature ecology & evolution · 2021Article
- PKC98E Regulates Odorant Responses inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Multiple channels of DEET repellency in Drosophila.Pest management science · 2020Article
- Evolution, developmental expression and function of odorant receptors in insects.The Journal of experimental biology · 2020Review
- Odor-Specific Deactivation Defects in aGenetics · 2019Article
- Article
- Access to the odor world: olfactory receptors and their role for signal transduction in insects.Cellular and molecular life sciences : CMLS · 2018Review
- Insect Pheromone Receptors - Key Elements in Sensing Intraspecific Chemical Signals.Frontiers in cellular neuroscience · 2018Review
- Correction: Odorant Responses and Courtship Behaviors Influenced by at4 Neurons in Drosophila.PloS one · 2018Article
- Odorant Receptor Sensitivity Modulation inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
Abstract
In insects, pheromones function as triggers to elicit complex behavior programs, such as courtship and mating behavior. In most species, the neurons tuned to pheromones are localized in a specific subset of olfactory sensilla located on the antenna called trichoid sensilla. In Drosophila there are two classes of trichoid sensilla, at1 sensilla that contain the dendrites of a single neuron that is specifically tuned to the male-specific pheromone 11-cis vaccenyl acetate (cVA), and at4 sensilla that contain three neurons with relatively poorly defined chemical specificity and function. Using a combination of odorant receptor mutant analysis, single sensillum electrophysiology and optogenetics, we have examined the chemical tuning and behavioral consequences of the three at4 olfactory neuron classes. Our results indicate that one class, Or65abc neurons, are unresponsive to cVA pheromone, and function to inhibit courtship behaviors in response to an unknown ligand, while the other two neuron classes, Or88a and Or47b neurons, are sensitive to a diverse array of fly and non-fly odors, and activation of these neurons has little direct impact on courtship behaviors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.